Delving into the Latest Updates on Guangzhou Aoyi Biotechnology Co., Ltd with Synapse

Overview

Lead is a heavy metal pollutant that is widely present in the environment and can seriously harm human health, especially the nervous system.Long noncoding RNAs (lncRNAs) play important roles in many physiol. and pathol. processes; however, there remains a lack of in-depth studies on the mol. mechanisms associated with lead neurotoxicity.Here, the authors' results showed that lead exposure inhibited cell proliferation and promoted cell apoptosis.The authors observed that lncRNAL20992 was significantly upregulated in a lead-induced neuronal-injury cell model according to quant. reverse transcription polymerase chain reaction.Silencing lncRNAL20992 revealed its significant functions involved in promoting cell apoptosis and inhibiting cell proliferation according to cell-counting kit-8, EdU assay, terminal detransferase dUTP nick-end labeling, and western blot.To elucidate the mol. mechanisms of lncRNAL20992, the authors used RNA pulldown mass spectrometry combined with bioinformatics anal. to discover 4 proteins (AIFM1, HSP7C, GRP78, and LMNA) that interacted with lncRNAL20992.Western blot anal. indicated that lncRNAL20992 involved in lead-induced neuronal injury was mediated by the 4 proteins.The authors' study constitutes the first investigation of the functions and related mechanisms of lncRNAL20992 and offered valuable insight into understanding the roles of lncRNA in lead-induced neurotoxicity.

100 Deals associated with Guangzhou Aoyi Biotechnology Co., Ltd

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100 Translational Medicine associated with Guangzhou Aoyi Biotechnology Co., Ltd

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