Delving into the Latest Updates on ASTA Medica GmbH with Synapse

Overview

A review, with 43 referencesMany different insults and mechanisms can lead to neurodegeneration.Potassium channel openers may play a role in counteracting or preventing this damage.A heterogeneous array of potassium channels, classified according to their electrophysiol. properties, has been identified.Different potassium channels are involved in several steps within the pathophysiol. cascade that ultimately leads to cell death; therefore, several potassium channel openers may interfere with different steps within the neurodegenerative cascade.However, it is possible that in case of severe insults potassium channel opening may not lead to neuroprotection, due to the fact that potassium channels are already endogenously activated and the extracellular potassium concentration is already very high.Thus, further channel opening may have no addnl. pos. effects.Selective drugs for individual channel subtypes should be used in predictive models of neurodegeneration; however, the currently known potassium channel openers are few and nonselective.The classes of drugs that need to be explored include potassium channel openers of the ATP-sensitive, high-conductance calcium-sensitive, and inward rectifier or leakage types.Selective openers for inward rectifier potassium channels are currently not available, although activation of 5-HT_1A receptors results in the induction of an inwardly rectifying potassium current.Potent neuroprotective properties have been described for different 5-HT_1A agonists in models of focal and global ischemia.Retigabine, a leakage-current potassium channel opener, has been shown to have neuroprotective effects in animal models of neurodegeneration.Of the currently available potassium channel openers, retigabine and BAY-X-3702 are active at nontoxic doses.Further research is needed to develop selective, well-tolerated potassium channel openers.

100 Deals associated with ASTA Medica GmbH

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100 Translational Medicine associated with ASTA Medica GmbH

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Pipeline

Pipeline Snapshot as of 19 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Anpirtoline hydrochloride ( 5-HT1B receptor x 5-HT3 receptor )	Pain More	Discontinued
Flezelastine hydrochloride ( 5-LOX x H1 receptor )	Neoplasms More	Discontinued