AbstractIn the field of medicine and cosmetics, transdermal experiments commonly used to evaluate the transdermal absorption of topical formulations. In this study, we applied Strat-M® membrane to study the in vitro transdermal properties of collagen peptide with different average molecular weight, and compared them with the transdermal absorption through excised mouse skin in vitro. The results showed that the transdermal rate of collagen peptide through Strat-M® and excised mouse skin increased linearly with time, and the different concentrations of collagen peptide solutions affected the final cumulative transmission. The cumulative transmission per unit area and transdermal rate of CP500 were both the highest among the four CPs. The cumulative transmission per unit area of collagen peptides through Strat-M® has a good correlation with that through excised mouse skin, R2 > 0.98. Strat-M® can replace the excised mouse skin in vitro to carry out the transdermal experiment of collagen peptide. Our results can be used to guide formulators in selecting vehicles in early development in the pharmaceutical, personal care and cosmetic industries.

Journal of Agricultural and Food Chemistry

Novel Cholecystokinin Secretion-Stimulating Peptides from Oat Protein Hydrolysate: Sequence Identification and Insight into the Mechanism of Action

Article

Author: Fu, Qiuyun ; Huang, Kai ; Cao, Hongwei ; Wang, Haiyan ; Guan, Xiao ; Song, Hongdong ; Xue, Lei

Cholecystokinin (CCK), secreted by enteroendocrine cells, plays a vital role in suppressing appetite. This study aimed to evaluate the in vivo effect of oat protein hydrolysate (OPH) on CCK secretion and elucidate the structural characteristics of the responsible peptides and their underlying mechanism of action. OPH was prepared by a simulated gastrointestinal digestion model. Intragastric administration of OPH in mice significantly increased plasma CCK levels. Using size exclusion column chromatography and liquid chromatography-tandem mass spectrometry, ten peptides were successfully identified, and their abilities to stimulate CCK secretion were evaluated in STC-1 cells. Four novel CCK secretion-stimulating peptides, including LLL, QQVFQPQ, QGDVVALPA, and DVNNNANQLEPR, were validated. Among them, QGDVVALPA exhibited the strongest activity. Inhibition experiments demonstrated that the calcium-sensing receptor and its coupled G-protein subtype G_q were involved in QGDVVALPA-stimulated CCK secretion. Additionally, downstream signaling molecules including intracellular Ca²⁺ and Ca²⁺/CaM-dependent protein kinase (CaMKII) were also required for QGDVVALPA to induce CCK secretion. Our findings highlight the potential of oat protein-derived hydrolysate and peptides as functional food ingredients to regulate satiety.

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Beijing Shengminuo Biotechnology Co., Ltd.

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