A study was conducted to develop an improved pig skin organ culture model (PSOCM) that, in comparison to previously-described models, presents optimized and prolonged tissue viability.PSOCM is a useful screening tool for a wide variety of applications.PSOCM is an ethical, highly-versatile, time-saving and economical alternative to animal testing and the use of reconstructed skin models.It is suitable for testing efficacy, mechanism of action and potential cytotoxicity of modulators of skin pigmentation, lipolysis and anti-aging compoundsExperiments to exploit this potent screening tool for further applications, such as testing potential irritants and/or sensitizers, are being finalized.