A fully automated apparatus for the fractionation of natural product extracts by parallel reversed-phase liquid chromatog. is presented.The 8 parallel chromatog. lines are supplied by common pumps via a distributor.Each line comprises a solid-phase extraction (SPE) unit where the DMSO extract diluted with H₂O is subjected to SPE and then re-extracted with a solvent mixture to feed the chromatog. column.The eluate fractions are also processed by SPE, re-extracted with an organic solvent, and collected into deep-well plates.The system is suitable to sep. >100 samples in the 70-100-mg scale within 24 h.

Abstracts of Papers, 221st ACS National Meeting, San Diego, CA, United States, April 1-5, 2001

Effective high throughput analysis and purification of combinatorial libraries

Author: God, Ralf ; Gumm, Holger ; Dutta, P. K.

The emergence of a huge number of combinatorial libraries has created an immediate need for the development of automated and universal techniques for high throughput (HT) anal. and purificationThe ability to efficiently analyze and purify the libraries is essential to reduce the costs of drug development.Our approach of using online coupling of HPLC with solid phase extraction (SPE) under high pressure can be used to fully automate the semi-prep purification process.The technique can remove DMSO from samples on line before injection onto the HPLC column.In the post-column stage, purified enriched organic compounds can be easily accessed buffer-free in any organic solvent in micro-titer plate format for easy integration into the HT screening process.The talk will also describe, a parallel HPLC approach where it is possible to sep. simultaneously eight different samples using a single pump, multi-channel detector and expert software system resp.Samples are separated by an array of HPLC columns, providing one column for each sample.A sophisticated flow control ensures equal chromatog. conditions in each channel.The results combined with our existing SPE coupling method of purification for throughput increase will also be discussed.

GIT Labor-Fachzeitschrift

Automatic isolation of polar and water soluble natural substances

Author: Jordan, Gregor ; God, Ralf ; Liebenau, Susan

A review.A liquid chromatog. system for the automated isolation of polar natural substances is described.First the chromatog. equipment is shown including a column combination of cationic exchanger, anionic exchanger, and a graphitized C material as well as an UV and a light-scattering detector.Further the resulting separation of complex polar organic mixtures is shown on model compound mixturesThe separation of cationic and anionic compounds on the cationic and anionic exchanger columns was achieved using an ammonium formate gradient at pH 3 and of nonionic compounds on the graphitized C column with an acetonitrile/ammonium formate gradient at pH 4.The testing of the chromatog. system on a fungus extract spiked with streptomycin is finally presented.

100 Deals associated with Sepiatec GmbH

100 Translational Medicine associated with Sepiatec GmbH

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 11 Nov 2025

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Sepiatec GmbH

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 11 Nov 2025

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing