Delving into the Latest Updates on Alanex Corp. with Synapse

Overview

New developments in cheminformatics are reviewed in the perspective of combinatorial chemistry and drug discovery. One of the most important trends is the realization that the ability to generate compounds in large numbers may not, in isolation, be helpful. It is more important to enrich combinatorial libraries with compounds which, if found to be active, can be quickly developed into viable drug candidates. Library design tools are being created that incorporate an accumulated medicinal chemistry experience necessary to produce compounds with desirable pharmacological properties. The development of methods to ensure chemical accessibility of designed libraries has also become important because of the need to integrate all steps of library generation, from design to synthesis, into one automated high-throughput process.

Chemistry of bis-dihydrotriazines: Rearrangement leading to the identification of neuropeptide Y receptor antagonists.

Author: Livnah, Nurit ; Hong, Yufeng ; Mazurov, Anatoly ; Krokhina, Galina ; Feinstein, Robert ; Ling, Anthony L. ; Gregor, Vlad

Synthesis by alternative routes of our chem. library containing guanidino substitutes led to the identification of a rearrangement involving bis-dihydrotriazines.For example 1,4-bis{[4,6-diamino-1-methoxyphenyl-1,2-dihydro-1,3,5-triazin-2-yl]-4-phenoxymethyl}benzene (4) undergoes rearrangement to the isomeric 1,4-bis{[4-amino-6-methoxyphenylamino-1,2-dihydro-1,3,5-triazin-2-yl]-4-phenoxymethyl}benzene (5).The products of rearrangement were identified to be potent neuropeptide Y Y1 receptor competitive antagonists.A plausible mechanism for the rearrangement of 4 to 5 will be presented.

LiBrain: software for automated design of exploratory and targeted combinatorial libraries

Author: Kuki, A. ; Shi, S. ; Polinsky, A. ; Feinstein, R. D.

LiBrain is a collection of software modules for automated combinatorial library design.Major bottlenecks associated with automating this process have been circumvented through the use of the Chem. Simulation Engine.This module is trained by chemists to determine the suitability of reactants for a specified reaction, to recognize the risk of undesirable side reactions and to predict the structures of the most likely reaction products.Other modules within LiBrain mine electronic catalogs of chems. for suitable reactants, incorporate desirable pharmacophoric features into the mols. of the library, and optimize the diversity of designed libraries.LiBrain also facilitates the tracking of library production and characterization, and automatically registers all synthesized compoundsBoth maximally diverse exploratory libraries and libraries focused on specific pharmacophores can be designed by LiBrain.

100 Deals associated with Alanex Corp.

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100 Translational Medicine associated with Alanex Corp.

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Pipeline

Pipeline Snapshot as of 09 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Other

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