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Last update 08 May 2025

NR0B1

Last update 08 May 2025

Basic Info

Synonyms

AHC, AHCH, DAX1

+ [7]

Introduction

Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions (PubMed:12482977, PubMed:32433991). Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis (PubMed:7990953, PubMed:8675564). May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).

Drugs associated with NR0B1

CN114751870

Patent Mining

Target

CTNNB x NR0B1 x Wnt

Mechanism

CTNNB inhibitors [+1]

Active Org.

Guizhou Medical University

Originator Org.

Guizhou Medical University

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with NR0B1

100 Translational Medicine associated with NR0B1

0 Patents (Medical) associated with NR0B1

976

Literatures (Medical) associated with NR0B1

01 Sep 2025·Comparative Biochemistry and Physiology Part D: Genomics and Proteomics

Genome-wide identification of FTZ-F1 genes in Chlamys farreri and analysis of ChIP-seq-based binding sites and potential target genes

Article

Author: Han, Lianxue ; Fan, Qichao ; Liu, Peipei ; Pan, Luqing ; Miao, Jingjing ; Lei, Kexin ; Li, Xiuru ; Fu, Ruifeng

FTZ-F1 (Fushi tarazu factor-1) is a crucial member of the monomeric orphan nuclear receptor family, playing essential roles in reproductive development, steroidogenesis, and metabolism. However, studies on the function of FTZ-F1 and its target genes in bivalve mollusks remain limited. In this study, we conducted a genome-wide analysis of Chlamys farreri and identified two FTZ-F1 family members, designated as Cf FTZ-F1 and Cf FTZ-F1b. We characterized their sequence features, evolutionary relationships, and protein structures. To elucidate its potential regulatory roles, we employed chromatin immunoprecipitation sequencing (ChIP-seq) to identify potential target genes, revealing 22,570 binding peaks. Motif analysis identified three conserved motifs consistent with the known binding characteristics of FTZ-F1. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses indicated that the target genes associated with these motifs are primarily involved in phospholipid metabolism, carbohydrate metabolism, steroid hormone biosynthesis, and key signaling pathways such as the PI3K-Akt pathway. Notably, genes involved in steroid hormone biosynthesis (CYP17A1, Srd5a1), gonadal differentiation (DAX-1, Dmrta2), and metabolic regulation (fumA, Adcy1) were identified as putative targets, suggesting that Cf FTZ-F1 may play a crucial role in these physiological processes. ChIP-qPCR further validated the binding sites of several target genes. This study sheds insights into the regulatory roles of FTZ-F1 in C. farreri, particularly its potential involvement in steroidogenesis, gonadal development, and metabolic regulation, laying the foundation for future functional investigations.

01 May 2025·Journal of Environmental Sciences

Impact of aerosol-radiation interaction and heterogeneous chemistry on the winter decreasing PM2.5 and increasing O3 in Eastern China 2014–2020

Article

Author: Qu, Yawei ; Li, Yasong ; Wang, Qin'geng ; Wu, Hao ; Xie, Min ; Wang, Tijian ; Li, Mengmeng

In the context of the prevalent winter air quality issues in China marked by declining PM_2.5 and rising O₃, this study employed a modified WRF-Chem model to examine the aerosol radiation interaction (ARI), heterogeneous chemistry (AHC), and their combined impact (ALL) on the variations in O₃ and PM_2.5 during the 2014-2020 in eastern China. Our analysis confirmed that ARI curtailed O₃ while elevating PM_2.5. AHC reduced O₃ through heterogeneous absorption of NO_x and hydroxides while notably fostering fine-grained sulfate, resulting in a PM_2.5 increase. Emission reductions mitigated the inhibitory impact of ARI on meteorological fields and photolysis rates. Emission reduction individually without aerosol feedback led to a 5.43 ppb O₃ increase and a 22.89 µg/m³ PM_2.5 decrease. ARI and AHC amplified the emission-reduction-induced (ERI) O₃ rise by 1.83 and 0.31 ppb, respectively. The response of ARI to emission diminution brought about a modest PM_2.5 increase of 0.31 µg/m³. Conversely, AHC, acting as the primary contributor, caused a noteworthy PM_2.5 decrease of 4.60 µg/m³. As efforts concentrate on reducing PM_2.5, the promotion of ARI on PM_2.5 counterbalanced the efficacy of emission reduction and the AHC-induced strengthening of PM_2.5 decrease. The ALL magnified the ERI O₃ increase by 38.9% and PM_2.5 decrease by 18.7%. Sensitivity experiments with different degrees of emission reduction demonstrated a consistent linear relationship between the ALL-induced enhancement of O₃ increase and PM_2.5 decrease to the ERI PM_2.5 decline. Our investigation revealed the complex connection between emissions and aerosol feedback in influencing air quality.

01 May 2025·Animal Reproduction Science

Transcriptome analysis of the ovary and testis of the pearl oyster Pinctada fucata: Identification of genes and pathways involved in gonadal development

Article

Author: Guo, Tangrongjun ; Chen, Weiwei ; Yu, Dahui ; Sang, Xiuxiu ; Zhu, Ruolin ; Guo, Ying ; Fan, Xianwei ; Bai, Lirong ; Wang, Pei

Pinctada fucata is a commercially vital species in global pearl aquaculture, producing high-quality pearls. To investigate the molecular regulatory mechanisms of gonadal development in P. fucata, transcriptome analysis was employed to compare expression profiles between testis and ovary across four key developmental stages. A total of 56.86 Gb of clean data was generated, including 392,510 circular consensus sequencing reads, among which 292,295 full-length non-chimeric (FLNC) sequences were identified. A transcript clustering analysis of FLNC reads revealed 89,645 high-quality consensus sequences. 17,646 gene loci were identified, including 8588 novel loci and 28,121 newly discovered transcripts, of which 17,350 were successfully annotated. The boundaries of 12,040 genes on the chromosomes were corrected, and 10,761 complete open reading frame sequences. 281 genes related to gonadal development were identified, including 186 genes with full-length cDNAs in the PacBio library. The study found that HUS1-like, MAD2A-X1, and BLM were stage-specifically upregulated during ovarian maturation, ensuring the accuracy of meiosis. Meanwhile, NR0B1, ETV7L-X5, and CAPRIN1-X2 promoted testicular maturation by regulating somatic cell differentiation and the germ cell microenvironment. KEGG enrichment analysis identified key pathways involved in gonadal development, including the ribosome, oxidative phosphorylation, DNA replication, and lysosome. Fatty acid metabolism was linked to ovarian maturation, while the FoxO and ErbB signaling pathways were associated with testicular maturation. These findings offer valuable insights into the molecular mechanisms regulating gonadal development in P. fucata and enhance genomic resources for this economically important species.

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NR0B1

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