NR0B1

Last update 23 Jan 2025

Basic Info

Synonyms

AHC, AHCH, DAX1

+ [7]

Introduction

Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).

100 Clinical Results associated with NR0B1

100 Translational Medicine associated with NR0B1

0 Patents (Medical) associated with NR0B1

972

Literatures (Medical) associated with NR0B1

01 May 2025·Journal of Environmental Sciences

Impact of aerosol-radiation interaction and heterogeneous chemistry on the winter decreasing PM2.5 and increasing O3 in Eastern China 2014–2020

Article

Author: Qu, Yawei ; Li, Yasong ; Wang, Qin'geng ; Wu, Hao ; Xie, Min ; Wang, Tijian ; Li, Mengmeng

In the context of the prevalent winter air quality issues in China marked by declining PM_2.5 and rising O₃, this study employed a modified WRF-Chem model to examine the aerosol radiation interaction (ARI), heterogeneous chemistry (AHC), and their combined impact (ALL) on the variations in O₃ and PM_2.5 during the 2014-2020 in eastern China. Our analysis confirmed that ARI curtailed O₃ while elevating PM_2.5. AHC reduced O₃ through heterogeneous absorption of NO_x and hydroxides while notably fostering fine-grained sulfate, resulting in a PM_2.5 increase. Emission reductions mitigated the inhibitory impact of ARI on meteorological fields and photolysis rates. Emission reduction individually without aerosol feedback led to a 5.43 ppb O₃ increase and a 22.89 µg/m³ PM_2.5 decrease. ARI and AHC amplified the emission-reduction-induced (ERI) O₃ rise by 1.83 and 0.31 ppb, respectively. The response of ARI to emission diminution brought about a modest PM_2.5 increase of 0.31 µg/m³. Conversely, AHC, acting as the primary contributor, caused a noteworthy PM_2.5 decrease of 4.60 µg/m³. As efforts concentrate on reducing PM_2.5, the promotion of ARI on PM_2.5 counterbalanced the efficacy of emission reduction and the AHC-induced strengthening of PM_2.5 decrease. The ALL magnified the ERI O₃ increase by 38.9% and PM_2.5 decrease by 18.7%. Sensitivity experiments with different degrees of emission reduction demonstrated a consistent linear relationship between the ALL-induced enhancement of O₃ increase and PM_2.5 decrease to the ERI PM_2.5 decline. Our investigation revealed the complex connection between emissions and aerosol feedback in influencing air quality.

01 Feb 2025·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

An autocatalytic hybridization circuit-based FRET aptasensor for detection of low-abundant sulfameter in human serum

Article

Author: Shen, Weili ; He, Yanping ; Tian, Ruifen ; Tao, Chen ; Zhang, Jingrui

Exposure to antibiotics is considered a potential risk factor for human health. Yet, the extensive and cost-effective detection of low-abundant antibiotics in complex matrices remains a significant challenge. Herein, an aptamer and an autocatalytic hybridization circuit (AHC) were used to fabricate a fluorescence resonance energy transfer (FRET) platform to detect sulfameter (SME) in human serum. The AHC system comprised two mutually motivated hybridization chain reactions (HCR) modules, ultimately producing long-branched DNA copolymeric nanowires. This mutually reciprocal activation of two HCR modules enables continuous signal amplification, providing the AHC system with wide linear range and high sensitivity for the SME detection. Compared to the HCR-based aptasensor, the AHC-based aptasensor exhibited a wider linear range and improved sensitivity (3.3 times greater). Under optimal conditions, the fluorescent AHC-based aptasensor demonstrated a linear range (R² was 0.996) from 0.5 to 2000 nM, with a low detection limit of 0.301 nM (S/N = 3). The fluorescent aptasensor was also validated by SME-spiked human serum samples, showing average recoveries ranging from 96.40 % to 109.30 %, with a relative standard deviation below 10.45 %. Furthermore, when tested on six human serum samples, the aptasensor results were consistent with those obtained from the commercial ELISA method. These findings demonstrate that the proposed aptasensor provides a promising approach for the practical monitoring of low-abundant SME in human serum.

01 Jan 2025·Journal of Voice

An Electroglottographic and Acoustic Study on Mandarin Speech in Male Heroin Users

Article

Author: Fan, Ningxue ; Li, Zhijun ; Guo, Hong ; Geng, Puyang ; Ling, Rong

Drug abuse can cause severe damage to the human speech organs. The vocal folds are one of the important speech organs that produce voice through vibration when airflow passes through. Previous studies have reported the negative effects of drugs on speech organs, including the vocal folds, but there is still limited research on relevant field. Therefore, the current study recruited 25 heroin users and 30 healthy controls with no history of drug use. Electroglottography and speech signals of 26 target sentences were collected from all participants. The results of the current study showed that the heroin group exhibited higher DFx1 and H1-A3, and lower DAx1 and jitter, and lower F1 frequency for /a/ and F2 frequency for /i/, but higher F2 frequency for /u/ compared to the no drug group. These findings suggested the presence of vocal hoarseness, frequency and amplitude distributions that differed from the norm, and a limited range of tongue movement in the heroin group. This study not only enhances the understanding of the effects of heroin on speech production but also has implications for detoxification treatment and speech rehabilitation for drug users.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

NR0B1

Basic Info

Related

Analysis