Last update 01 Nov 2024

PCDHA2

Last update 01 Nov 2024

Basic Info

Synonyms

PCDH-alpha-2, PCDHA2, protocadherin alpha 2

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Introduction

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

100 Clinical Results associated with PCDHA2

100 Translational Medicine associated with PCDHA2

0 Patents (Medical) associated with PCDHA2

Literatures (Medical) associated with PCDHA2

29 Dec 2022·Neuro endocrinology letters

Construction and evaluation of a prognosis prediction model for thyroid carcinoma based on lipid metabolism-related genes.

Article

Author: Wang, Fan ; Wang, Zhixing

BACKGROUNDThyroid cancer is one of the most common tumors worldwide, and the molecular studies on lipid metabolism disorders in thyroid cancer remain unclear.AIMThis study intends to explore the model constructed by lipid metabolism genes to evaluate the prognosis of thyroid cancer.METHODSThe data of thyroid cancer patients were obtained by The Cancer Genome Atlas database. The cancerous tissue from the thyroid gland was used to evaluate specific genes. Besides, Gene Set Enrichment Analysis (GSEA) and Cox proportional hazard regression models were adopted to identify the lipid metabolism genes of thyroid cancer. The survival status of patients with a risk score was analyzed by the Kaplan-Meier method, and the accuracy of the risk score was evaluated by the receiver operating characteristic (ROC) curve.FINDINGSAge, tumor node metastasis stage, and risk score were independent prognostic factors for thyroid cancer. FADS1, WNT3A, PCDHA2 and ITGA5 were high-risk genes. The prognostic risk score model was established according to the four lipid metabolism genes. The overall survival of patients with high-risk thyroid cancer was significantly lower than that of low-risk patients in this study.DISCUSSIONAccording to the above findings, FADS1, WNT3A, PCDHA2, and ITGA5 are unfavorable factors for the prognosis of thyroid cancer in the pathway of lipid metabolism. A prognostic model composed of the above four genes was constructed, and it was confirmed that the model was not affected by age and sex.CONCLUSIONThe prognosis prediction model for thyroid cancer based on lipid metabolism related genes was successfully constructed, and the model had good predictive ability for the prognosis of thyroid cancer patients.

11 Nov 2021·OncogeneQ1 · MEDICINE

Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients

Q1 · MEDICINE

Article

Author: Eckert, Richard L ; Shetty, Amol C ; Kaetzel, David M ; Noonan, Frances P ; Adhikary, Gautam ; De Fabo, Edward C ; Jin, Yuxin ; Merlino, Glenn ; Rigi, Mohammed ; Day, Chi-Ping ; Manojlovic, Zarko ; Webb, Michelle G ; Craig, David W ; Pamidimukkala, Nidhi ; Slominski, Andrzej T ; Kwok, Eric ; Puts, Gemma S ; Snyder, Devin ; Novak, Marián ; Xu, Yili ; Leonard, M Kathryn ; Mahurkar, Anup ; Matsangos, Nicolette ; Carpten, John D ; Slominski, Radomir M

Hepatocyte growth factor-overexpressing mice that harbor a deletion of the Ink4a/p16 locus (HP mice) form melanomas with low metastatic potential in response to UV irradiation. Here we report that these tumors become highly metastatic following hemizygous deletion of the Nme1 and Nme2 metastasis suppressor genes (HPN mice). Whole-genome sequencing of melanomas from HPN mice revealed a striking increase in lung metastatic activity that is associated with missense mutations in eight signature genes (Arhgap35, Atp8b4, Brca1, Ift172, Kif21b, Nckap5, Pcdha2, and Zfp869). RNA-seq analysis of transcriptomes from HP and HPN primary melanomas identified a 32-gene signature (HPN lung metastasis signature) for which decreased expression is strongly associated with lung metastatic potential. Analysis of transcriptome data from The Cancer Genome Atlas revealed expression profiles of these genes that predict improved survival of patients with cutaneous or uveal melanoma. Silencing of three representative HPN lung metastasis signature genes (ARRDC3, NYNRIN, RND3) in human melanoma cells resulted in increased invasive activity, consistent with roles for these genes as mediators of the metastasis suppressor function of NME1 and NME2. In conclusion, our studies have identified a family of genes that mediate suppression of melanoma lung metastasis, and which may serve as prognostic markers and/or therapeutic targets for clinical management of metastatic melanoma.

01 Oct 2021·Brain Communications

Maternal immune activation downregulates schizophrenia genes in the foetal mouse brain

Article

Author: Handunnetthi, Lahiru ; Hamley, Joseph C ; Knight, Julian C ; Saatci, Defne

AbstractSusceptibility to schizophrenia is mediated by genetic and environmental risk factors. Maternal immune activation by infections during pregnancy is hypothesized to be a key environmental risk factor. However, little is known about how maternal immune activation contributes to schizophrenia pathogenesis. In this study, we investigated if maternal immune activation influences the expression of genes associated with schizophrenia in foetal mouse brains. We found that two sets of schizophrenia genes were downregulated more than expected by chance in the foetal mouse brain following maternal immune activation, namely those genes associated with schizophrenia through genome-wide association study (fold change = 1.93, false discovery rate = 4 × 10−4) and downregulated genes in adult schizophrenia brains (fold change = 1.51, false discovery rate = 4 × 10−10). We found that these genes mapped to key biological processes, such as neuronal cell adhesion. We also identified cortical excitatory neurons and inhibitory interneurons as the most vulnerable cell types to the deleterious effects of this interaction. Subsequently, we used gene expression information from herpes simplex virus 1 infection of neuronal precursor cells as orthogonal evidence to support our findings and to demonstrate that schizophrenia-associated cell adhesion genes, PCDHA2, PCDHA3 and PCDHA5, were downregulated following herpes simplex virus 1 infection. Collectively, our results provide novel evidence for a link between genetic and environmental risk factors in schizophrenia pathogenesis. These findings carry important implications for early preventative strategies in schizophrenia.

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