Last update 01 Nov 2024

NKX2-1

Last update 01 Nov 2024

Basic Info

Synonyms

BCH, Homeobox protein NK-2 homolog A, Homeobox protein Nkx-2.1

+ [10]

Introduction

Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).

Drugs associated with NKX2-1

WO2024072902

Patent Mining

Target

NKX2-1

Mechanism-

Active Org.

Agilent Technologies, Inc.

Originator Org.

Agilent Technologies, Inc.

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with NKX2-1

100 Translational Medicine associated with NKX2-1

0 Patents (Medical) associated with NKX2-1

1,636

Literatures (Medical) associated with NKX2-1

01 Dec 2024·Radiology Case Reports

First reported case of primary small cell cancer of the pancreas with positive TTF-1 tumor marker

Article

Author: Merza, Nooraldin ; Hashim, Hashim Talib ; Al-Obaidi, Ahmed Dheyaa ; Agha, Iya ; Al-Badri, Sajjad Ghanim ; Al-Obaidi, Hasan ; Mora, Maximo ; Harb, Hussein ; Moliya, Pratiksha ; Othman, Assalah ; Patel, Avani

Small cell carcinomas are very aggressive malignancies that are most often linked with lung cancer, although they may also develop in the pancreas, colon, rectum, skin, and cervix. SCC of the pancreas accounts for about 1% of these neoplasms. An 88-year-old male with several comorbidities who presented with significant weight loss was diagnosed with metastatic pancreatic neuroendocrine carcinoma after complaining of persistent epistaxis and back pain. This case underscores the significance of using atypical tumor markers, such as thyroid transcription factor 1, to diagnose small-cell pancreatic cancer. It also emphasizes the importance of a multidisciplinary, patient-centered approach to managing these aggressive tumors.

01 Oct 2024·Journal of the American Veterinary Medical Association

Prospective assessment of canine thyroid cancer—part I: nodal metastatic rate and impact of nodal immunohistochemistry in 70 dogs

Article

Author: Kim, Dae Young ; McKenna, Charly ; Story, Ashton L ; Selmic, Laura E ; Mickelson, Megan A ; Garrett, Colleen J ; Karnia, James J ; Johnson, Carley ; Dornbusch, Josephine A ; Oblak, Michelle L ; Skinner, Owen T ; Hoehn, Malissa M ; Lapsley, Janis M

AbstractOBJECTIVETo determine the rate of nodal metastasis in dogs with thyroid cancer and evaluate whether immunohistochemistry (IHC) identifies additional metastases beyond evaluation with H&E.ANIMALS70 prospectively enrolled client-owned dogs with thyroid cancer managed with thyroidectomy.METHODSDogs underwent thyroidectomy with concurrent elective bilateral medial retropharyngeal (MRP) ± deep cervical lymphadenectomy. Thyroid tumors and associated lymph nodes were reviewed by a single board-certified pathologist. Immunohistochemistry was used for all primary tumors (thyroid transcription factor-1 and calcitonin) to support a diagnosis of follicular or medullary carcinoma. Lymph nodes without evidence of metastasis after H&E review were labeled with the antibody associated with the wider uptake in the primary tumor.RESULTS77 thyroid cancers were resected from the 70 dogs enrolled, including 61 (79.2%) follicular, 8 (10.7%) medullary, and 7 (9.3%) mixed follicular/medullary carcinomas, with 1 (1.3%) carcinosarcoma. Twelve dogs had evidence of nodal metastasis following H&E review. Occult micrometastasis was identified in 1 dog following nodal IHC, resulting in documented metastasis in 13 of 70 (18.6%) dogs. Metastasis was more common with medullary (5/8) and follicular/medullary carcinoma (3/7) than follicular carcinoma (5/61). All MRP metastases were ipsilateral (7/77 [9.1%]), without contralateral MRP metastases (0/62). Fourteen of 41 (34.1%) deep cervical lymph nodes were metastatic.CLINICAL RELEVANCENodal metastasis was uncommon for follicular carcinoma but was seen in > 50% of dogs with thyroid cancer involving a medullary component. Routine nodal IHC appears to be low yield for thyroid carcinoma. Extirpation of ipsilateral MRP and identifiable deep cervical lymph nodes is recommended with thyroidectomy until detailed preoperative risk stratification becomes available.

01 Oct 2024·ELECTROPHORESIS

A semen‐specific deoxyribonucleic acid methylation model for epigenetic age estimation and its robustness under environmental challenges

Article

Author: Filoglu, Gonul ; Ersoy, Gokhan ; Er, Sena ; Abik, Zehra ; Ozkara, Hamdi ; Bulbul, Ozlem

AbstractIn forensic investigations, semen samples are a common form of biological evidence, especially in cases involving sexual assault. Therefore, accurately estimating the age of an individual is crucial in criminal cases. This study presents a novel age estimation model based on semen‐specific CpG methylation patterns. A multiplex panel was developed, consisting of 12 CpG sites (PARP14, C5orf25, cg23488376, MXRA5, PFKFB3, DLL1, NOX4, cg12837463, TTC7B, KCNA7, NKX2‐1, and SYNE4), which exhibit strong correlations with age. Additionally, this study investigates the resilience of these methylation markers under simulated environmental challenges. We collected ejaculate samples from a diverse cohort of 115 male individuals, aged 20–71 years, who underwent deoxyribonucleic acid extraction and bisulfite conversion. Methylation levels of the selected CpG sites were assessed using a SNaPshot assay, which revealed significant correlations with chronological age. We developed and validated two robust age estimation models through stepwise and enter regression analyses, achieving reliable accuracy with mean absolute errors ranging from 3.81 to 4.1 years. Additionally, the study also investigated the robustness of semen stains under diverse environmental conditions, including fabric type, washing, hematin exposure, and UV‐C light. The selected methylation markers demonstrated remarkable resilience despite the challenges posed by washing procedures and environmental exposure, confirming their potential for age estimation in forensic genetics. This research presents successful age estimation models, emphasizing the strong correlations between methylation levels and chronological age. The proposed methodology's accuracy is affirmed through model validation on an independent test set, while also highlighting the resilience of semen stains on fabrics under varying storage and washing conditions.

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NKX2-1

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