LRIT1

Last update 08 May 2025

Basic Info

Synonyms

DKFZP434K091, FIGLER9, leucine rich repeat, Ig-like and transmembrane domains 1

+ [7]

Introduction

Photoreceptor synaptic protein essential for normal vision (By similarity). Involved in synapse formation in cone photoreceptor cells (By similarity).

100 Clinical Results associated with LRIT1

100 Translational Medicine associated with LRIT1

0 Patents (Medical) associated with LRIT1

Literatures (Medical) associated with LRIT1

01 Mar 2018·Cell ReportsQ1 · BIOLOGY

LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors

Q1 · BIOLOGY

ArticleOA

Author: Sarria, Ignacio ; Kefalov, Vladimir J ; Kolesnikov, Alexander V ; Wang, Yuchen ; Martemyanov, Kirill A ; Cao, Yan ; Pahlberg, Johan ; Sampath, Alapakkam P ; Ingram, Norianne T ; Orlandi, Cesare ; Kamasawa, Naomi

Cone photoreceptors scale dynamically the sensitivity of responses to maintain responsiveness across wide range of changes in luminance. Synaptic changes contribute to this adaptation, but how this process is coordinated at the molecular level is poorly understood. Here, we report that a cell adhesion-like molecule, LRIT1, is enriched selectively at cone photoreceptor synapses where it engages in a trans-synaptic interaction with mGluR6, the principal receptor in postsynaptic ON-bipolar cells. The levels of LRIT1 are regulated by the neurotransmitter release apparatus that controls photoreceptor output. Knockout of LRIT1 in mice increases the sensitivity of cone synaptic signaling while impairing its ability to adapt to background light without overtly influencing the morphology or molecular composition of photoreceptor synapses. Accordingly, mice lacking LRIT1 show visual deficits under conditions requiring temporally challenging discrimination of visual signals in steady background light. These observations reveal molecular mechanisms involved in scaling synaptic communication in the retina.

01 Mar 2018·Cell ReportsQ1 · BIOLOGY

Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse Formation in Cone Photoreceptor Cells and Visual Acuity

Q1 · BIOLOGY

ArticleOA

Author: Kozuka, Takashi ; Matsushita, Kenji ; Omori, Yoshihiro ; Chaya, Taro ; Ueno, Akiko ; Watanabe, Satoshi ; Kajimura, Naoko ; Okada, Yasushi ; Sugita, Yuko ; Kon, Tetsuo ; Kuwahara, Ryusuke ; Yoshida, Satoyo ; Furukawa, Takahisa

In the vertebrate retina, cone photoreceptors play crucial roles in photopic vision by transmitting light-evoked signals to ON- and/or OFF-bipolar cells. However, the mechanisms underlying selective synapse formation in the cone photoreceptor pathway remain poorly understood. Here, we found that Lrit1, a leucine-rich transmembrane protein, localizes to the photoreceptor synaptic terminal and regulates the synaptic connection between cone photoreceptors and cone ON-bipolar cells. Lrit1-deficient retinas exhibit an aberrant morphology of cone photoreceptor pedicles, as well as an impairment of signal transmission from cone photoreceptors to cone ON-bipolar cells. Furthermore, we demonstrated that Lrit1 interacts with Frmpd2, a photoreceptor scaffold protein, and with mGluR6, an ON-bipolar cell-specific glutamate receptor. Additionally, Lrit1-null mice showed visual acuity impairments in their optokinetic responses. These results suggest that the Frmpd2-Lrit1-mGluR6 axis regulates selective synapse formation in cone photoreceptors and is essential for normal visual function.

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LRIT1

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