ZNF768

Last update 08 May 2025

Basic Info

Synonyms

FLJ23436, zinc finger protein 768, ZNF768

Introduction

Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable).

100 Clinical Results associated with ZNF768

100 Translational Medicine associated with ZNF768

0 Patents (Medical) associated with ZNF768

Literatures (Medical) associated with ZNF768

01 Feb 2023·Thoracic Cancer

The development of a tumor‐associated autoantibodies panel to predict clinical outcomes for immune checkpoint inhibitor‐based treatment in patients with advanced non‐small‐cell lung cancer

Article

Author: Liu, Xiaoyan ; Zhang, Xiaotong ; Zhao, Jing ; Zhong, Wei ; Yue, Yuan ; Zhang, Li ; Gao, Xiaoxing ; Si, Xiaoyan ; Wu, Yang ; Xu, Yan ; Wang, Hanping ; Liu, Xiangning ; Chen, Minjiang ; Wang, Mengzhao

AbstractBackgroundImmune checkpoint inhibitors (ICIs) have become one important therapeutic strategy for advanced non‐small‐cell lung cancer (NSCLC). It remains imperative to identify reliable and convenient biomarkers to predict both the efficacy and toxicity of immunotherapy, and tumor‐associated autoantibodies (TAAbs) are recognized as one of the promising candidates for this.Patients and MethodsThis study enrolled 97 advanced NSCLC patients with ICI‐based immunotherapy treatment, who were divided into a training cohort (n = 48) and a validation cohort (n = 49), and measured for the serum level of 35 TAAbs. According to the statistical association between the serum positivity and clinical outcome of each TAAb in the training cohort, a TAAb panel was developed to predict the progression‐free survival (PFS), and further examined in the validation cohort and in different subgroups. Similarly, another TAAb panel was derived to predict the occurrence of immune‐related adverse events (irAEs).ResultsIn the training cohort, a 7‐TAAb panel composed of p53, CAGE, MAGEA4, GAGE7, UTP14A, IMP2, and PSMC1 TAAbs was derived to predict PFS (median PFS [mPFS] 9.9 vs. 4.3 months, p = 0.043). The statistical association between the panel positivity and longer PFS was confirmed in the validation cohort (mPFS 11.1 vs. 4.8 months, p = 0.015) and in different subgroups of patients. Moreover, another 4‐TAAb panel of BRCA2, MAGEA4, ZNF768, and PARP TAAbs was developed to predict the occurrence of irAEs, showing higher risk in panel‐positive patients (71.43% vs. 28.91%, p = 0.0046).ConclusionsCollectively, our study developed and validated two TAAb panels as valuable prognostic biomarkers for immunotherapy.

02 Nov 2021·Molecular & Cellular Oncology

ZNF768: controlling cellular senescence and proliferation with ten fingers

Article

Author: Mallette, Frédérick A. ; Villot, Romain ; Joubert, Philippe ; Elowe, Sabine ; Laplante, Mathieu ; Manem, Venkata S. K. ; Kolnoguz, Aliona ; Poirier, Audrey ; Devillers, Romain

We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellular senescence, while its overexpression allows cells to bypass oncogene-induced senescence. Elevated ZNF768 levels is common in tumors, suggesting that ZNF768 may help to escape cellular senescence, sustain proliferation and promote malignant transformation. Here, we discuss these recent findings and highlight key questions emerging from our work.

25 Jan 2019·Nucleic Acids ResearchQ2 · BIOLOGY

MIR sequences recruit zinc finger protein ZNF768 to expressed genes

Q2 · BIOLOGY

ArticleOA

Author: Imhof, Axel ; Forné, Ignasi ; Gruber-Eber, Anita ; Rohrmoser, Michaela ; Geyer, Matthias ; Yahia, Yousra ; Eick, Dirk ; Krebs, Stefan ; Greifenberg, Ann Katrin ; Blum, Helmut ; Maqbool, Muhammad Ahmad ; Descostes, Nicolas ; Andrau, Jean-Christophe ; Friedel, Caroline C ; Kluge, Michael

Mammalian-wide interspersed repeats (MIRs) are retrotransposed elements of mammalian genomes. Here, we report the specific binding of zinc finger protein ZNF768 to the sequence motif GCTGTGTG (N20) CCTCTCTG in the core region of MIRs. ZNF768 binding is preferentially associated with euchromatin and promoter regions of genes. Binding was observed for genes expressed in a cell type-specific manner in human B cell line Raji and osteosarcoma U2OS cells. Mass spectrometric analysis revealed binding of ZNF768 to Elongator components Elp1, Elp2 and Elp3 and other nuclear factors. The N-terminus of ZNF768 contains a heptad repeat array structurally related to the C-terminal domain (CTD) of RNA polymerase II. This array evolved in placental animals but not marsupials and monotreme species, displays species-specific length variations, and possibly fulfills CTD related functions in gene regulation. We propose that the evolution of MIRs and ZNF768 has extended the repertoire of gene regulatory mechanisms in mammals and that ZNF768 binding is associated with cell type-specific gene expression.

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ZNF768

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