Ionotropic glutamate receptors

Flexible integration of warming and cooling pathways underlies thermal homeostasis in larval Drosophila .

Tripartite trans-synaptic assemblies directly link pre- and postsynaptic complexes crucial for synaptic transmission.

We applied quantitative mass spectrometry to define how sensory experience alters the synaptic proteome in primary sensory cortex. Our results demonstrate that sensory deprivation reduced proteins implicated in spine enlargement and synaptic strength and increased protein-degradation machinery at synapses. Importantly, we identified novel synaptic proteins whose levels were affected by sensory deprivation but whose synaptic roles have not yet been characterized in mammalian neurons. Thus, this study provides a crucial starting point for numerous investigations of the molecular basis for synaptic modulation and demonstrates the feasibility of using this method to define synaptic proteomes under different sensory rearing conditions.