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Last update 08 May 2025

miR-15a

Last update 08 May 2025

Basic Info

Synonyms

hsa-mir-15a, microRNA 15a, MIR15A

+ [1]

Introduction-

Drugs associated with miR-15a

US20240150765

Patent Mining

Target

MIR129 x MIR139 x MIR140 x MIR194 x miR-145 x miR-15a x miR-16 x miR-192

Mechanism-

Active Org.

Curamir Therapeutics, Inc.

Originator Org.

Curamir Therapeutics, Inc.

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with miR-15a

100 Translational Medicine associated with miR-15a

0 Patents (Medical) associated with miR-15a

1,091

Literatures (Medical) associated with miR-15a

01 Jun 2025·Environmental Research

Circulating MicroRNAs in association with urinary arsenic: A community-based multi-center study in China

Article

Author: Qu, Jingli ; Jiang, Qin ; Yuan, Yu ; Ma, Jixuan ; Wang, Yufei ; Wang, Yaxin ; He, Meian ; Wang, Bin ; Long, Pinpin ; You, Yutong ; Chen, Weihong ; Wu, Tangchun ; Li, Wending ; Xu, Xuedan ; Li, Zhaoyang

The profile of plasma miRNAs in association with arsenic exposure remains largely unclear. We aim to identify plasma miRNAs assoicated with urinary arsenic using a two-stage design in Chinese population. The discovery group, Shimen panel, consists of 19 high vs. low arsenic-exposed pairs selected from 1095 residents in an arsenic-contaminated area. The validation group, Wuhan-Zhuhai panel, consists of 53 community-dwelling participants with moderate arsenic exposure. Plasma miRNAs were measured by microarray in the Shimen panel and by sequencing in the Wuhan-Zhuhai panel. Arsenic levels in urine and plasma were quantified using inductively coupled plasma mass spectrometry. During the discovery stage, 16 miRNAs were found to be differentially expressed between high and low urinary arsenic groups in the Shimen panel (fold change >2, P < 0.05). Seven miRNAs (miR-101-3p, miR-142-3p, miR-148a-3p, miR-15a-5p, miR-199a-3p, miR-27b-3p, and miR-340-5p) were validated to have a positive association with log-transformed urinary arsenic levels in the Wuhan-Zhuhai panel (P < 0.05). Furthermore, five of the seven miRNAs were also associated with arsenic in plasma. The identified miRNAs were primarily associated with cancer-related pathways. These identified miRNAs would serve as crucial biomarkers for arsenic exposure, elucidating the epigenetic mechanisms underlying arsenic-induced toxicity and carcinogenesis.

01 Apr 2025·Heart Rhythm

Diagnostic and Prognostic Significance of miRNA-15a-5p, 16-5p, and 92a-3p in Arrhythmogenic Right Ventricular Cardiomyopathy

Article

Author: Joseph, Shaylyn ; Duru, Firat ; Borowiec, Karolina ; da Costa Darrieux, Francisco Carlos ; Woźniak, Olgierd ; Scanavacca, Maurício Ibrahim ; Hamilton, Robert M ; Chatterjee, Diptendu ; Fatah, Meena ; Guan, Fu ; D'Arezzo Pessente, Gabrielle ; Saguner, Ardan M ; Sacilotto, Luciana ; Brunckhorst, Corinna B ; Krieger, José Eduardo ; Rosa Neta, Antonia Pereira ; Biernacka, Elżbieta Katarzyna ; Silbiger, Vivian Nogueira ; Luchessi, Andre D

BACKGROUNDArrhythmogenic Right Ventricular Cardiomyopathy (ARVC) presents diagnostic challenges and significant clinical burden due to life-threatening ventricular arrhythmias, compounded by the limited ability to predict patient prognosis using current clinical parameters. MicroRNAs (miRNAs) offer potential as markers in cardiac diseases, including ARVC, providing insights into disease pathogenesis, identification, and prognosis. However, current diagnostic criteria lack sensitivity and specificity, highlighting the need for novel markers like miRNAs to better understand ARVC's complex pathophysiological mechanisms.OBJECTIVEThis multi-site study assessed circulating miRNA expression in ARVC patients, stratified by five-year event-free survival risk, to explore their potential as a marker for improving ARVC diagnosis and prognosis.METHODSBlood samples from 102 ARVC patients, 24 Brugada Syndrome (BrS) patients, and 22 healthy controls were analyzed for the expression of 20 miRNAs using TaqMan quantitative real-time PCR, ARVC patients were stratified by five-year event-free survival risk. Six candidate miRNAs were selected for further analysis, and machine learning algorithms were applied for classification and risk stratification based on miRNA profiles. Additionally, genotyping and functional annotation of miRNA targets were performed.RESULTSSix miRNAs exhibited differential expression between high and low-risk ARVC patients. MiR-15a-5p, miR-16-5p, and miR-92a-3p demonstrated the best performance in risk stratification. MiR-15a-5p also displayed higher expression in patients with adverse cardiac events. Comparative analysis with BrS patients and healthy controls consistently demonstrated increased expression of these miRNAs in ARVC.CONCLUSIONThis study highlights miRNAs' potential to enhance the diagnosis disease progression, and clinical outcomes of ARVC, supporting further research to improve patient care.

01 Apr 2025·Neurochemical Research

HDAC1 Promotes Hippocampal Neuronal Pyroptosis in Epileptic Mice Through the miR-15a-5p/Caspase-1 Axis

Article

Author: Sun, Fenghua ; Pu, Binyu ; Lv, Yun

Status epilepticus (SE) is a life-threatening disorder associated with neuronal pyroptosis. This study aims to explore the mechanism of HDAC1 in hippocampal neuronal pyroptosis induced by kainic acid in mice, providing a theoretical basis for SE treatment. A mouse model of SE was established by kainic acid. After sh-HDAC1 injection, the severity of SE and hippocampal neuronal damage were assessed. Cell model was established using kainic acid-induced HT22, followed by detection of HDAC1, miR-15a-5p, Caspase-1, cleaved Caspase-1, H3K9ac, and GSDMD-N using qRT-PCR and Western blot assays. Levels of IL-1β, IL-18, and LDH were measured. The enrichment of HDAC1 on the miR-15a-5p promoter was detected. The binding of miR-15a-5p to Caspase-1 was validated. We found that HDAC1 was highly expressed in kainic acid-induced SE. HDAC1 knockdown alleviated the symptoms of SE, inhibited cleaved Caspase-1, GSDMD-N, IL-1β, and IL-18, and suppressed hippocampal neuronal pyroptosis. HDAC1 bound to the miR-15a-5p promoter and reduced H3K9ac, thereby inhibiting miR-15a-5p expression. miR-15a-5p bound to Caspase-1 and inhibited Caspase-1 expression. Inhibiting miR-15a-5p or overexpressing Caspase-1 partially reversed the inhibitory effect of si-HDAC1 on kainic acid-induced cell pyroptosis. In conclusion, HDAC1 aggravates hippocampal neuronal pyroptosis in SE via the miR-15a-5p/Caspase-1 axis through deacetylation of H3K9.

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miR-15a

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