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Last update 08 May 2025

CD180

Last update 08 May 2025

Basic Info

Synonyms

CD180, CD180 antigen, CD180 molecule

+ [5]

Introduction

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

Drugs associated with CD180

HG-1151

Target

CD180 x CD86

Mechanism

CD180 inhibitors [+1]

Active Org.-

Originator Org.

Human Genome Sciences, Inc.

Active Indication-

Inactive Indication

Immune System Diseases

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CD180

100 Translational Medicine associated with CD180

0 Patents (Medical) associated with CD180

241

Literatures (Medical) associated with CD180

24 Mar 2025·Bioscience, Biotechnology, and Biochemistry

Tetragonia tetragonioides extract prevented high-fat-diet-induced obesity and changed hepatic and adipose transcriptomic signatures in C57BL/6J male mice

Article

Author: Kim, Tae Gyun ; Hong, Hye Ryeong ; Kim, Young Jun ; Lee, Geung-Joo ; Oh, Hea Ry ; Han, Bok Kyung ; Reaney, Martin J T ; Shim, Youn Young ; Park, Jinbong ; Hong, Ji Youn ; Shin, Eui Cheol ; Park, Yong Hyun ; Pan, Jeong Hoon ; Shin, Hyo Ri ; Lee, Kangwook ; Cho, Tae Jin ; Cho, Hyung Taek ; Do, Seon Gil ; Kim, Jae Kyeom ; Kim, Hyun Jin ; Ko, Seong-Gyu ; Han, Yohan

AbstractObesity, often driven by high-fat diets (HFDs), is a major global health issue, necessitating effective preventive measures. Tetragonia tetragonoides, a plant with known medicinal properties, has not been extensively studied for its effects on HFD-induced obesity and related genetic changes in mice. This study explores the impact of T. tetragonoides extract (TTE; 300 mg/kg) on obesity-related traits in C57BL/6J male mice, with a focus on transcriptomic changes in the liver and white adipose tissue (WAT). Over 8 weeks, TTE supplementation led to significant reductions in obesity-related phenotypes and modulated gene expression altered by HFD. Key genes like Cd180 and MUPs, linked to immune responses and lipid metabolism, were notably influenced by TTE. The study highlighted TTE’s effects on lipid metabolism pathways in the liver and immune processes in WAT, underscoring its potential as an anti-obesity agent, while advocating for further research into its bioactive components.

01 Mar 2025·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Corrigendum to “Ligation of CD180 contributes to endotoxic shock by regulating the accumulation and immunosuppressive activity of myeloid-derived suppressor cells through STAT3.” [Biochim Biophys Acta (BBA) - Mol Basis Dis 2019; 1865(3):535–546.]

Author: Shi, Hui ; Yan, Fenglian ; Ming, Jiankuo ; Li, Zhihua ; Hu, Yuan ; Ma, Qun ; Zhu, Yuzhen ; Wang, Cuiling ; Ning, Zhaochen ; Zhang, Hui ; Yao, Xiaoying ; Si, Chuanping ; Cheng, Panpan ; Zhang, Junfeng ; Li, Chunxia ; Dai, Jun ; Xiong, Huabao ; Dong, Guanjun ; Li, Xuehui ; Yang, Yonghong

01 Mar 2025·Food Research International

Influence of synthesis temperature on the active performance of doped‑carbon dots embedded in polyvinyl alcohol and their potential for active food packaging

Article

Author: Bumbudsanpharoke, Nattinee ; Wanmolee, Wanwitoo ; Thanawutthiphong, Pornchanok ; Ko, Seonghyuk ; Kaewpetch, Thitiporn

This study explores how synthesis temperature influences the properties and functionalities of sulfur‑nitrogen doped carbon dots (S,N-doped CDs) derived from citric acid and cysteine. The focus lies on their potential in bionanocomposite films for active packaging. Bionanocomposite films were prepared by incorporating CDs synthesized at different temperatures (160, 180, and 200 °C) into a polyvinyl alcohol (PVOH) matrix. CD160 displayed a crystalline structure below 10 nm and demonstrated the strongest antifungal and antibacterial activity, as evidenced by the largest clear zones. This superior performance is presumably due to their high N and S content, as shown by the larger redshift in their photoluminescence spectra upon longer wavelength excitation and elemental analysis. CD180 lacked well-defined lattice fringes, indicating an amorphous structure with larger cluster sizes ranging from 10 to 100 nm. Interestingly, UV-blocking and antibacterial efficacy of both films remained high (over 95% UVA block and 5 log₁₀ CFU/mL reduction in bacteria) regardless of CD crystallinity and size. However, the PVOH-CD180 film exhibited more photoluminescence, most likely due to larger defect-related emission centers. In contrast, CD200 had the weakest antifungal and antibacterial activity. While the PVOH-CD200 film achieved a 5 log₁₀ CFU/mL reduction in Gram-positive bacteria, it only managed a 4 log₁₀ CFU/mL reduction in Gram-negative bacteria under contact conditions at 37 °C for 24 h. In addition, the PVOH-CD200 film had the highest antioxidant activity, 88% DPPH radical scavenging, whereas the others had 80%. These findings underscore the critical role of synthesis temperature in tailoring S,N-doped CDs for specific applications within active packaging, where the desired properties dictate the optimal temperature. Preliminary studies suggest that PVOH-CD films have the potential to extend the shelf-life of sweet bread, demonstrating their promise as bionanocomposite active food packaging materials.

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CD180

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