Synonyms Estrogen-regulated protein LIV-1, LIV-1, LIV1 + [8] |
Introduction Acts as a zinc-influx transporter (PubMed:12839489). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:27274087). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). |
Target |
Mechanism LIV-1 modulators |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePhase 1 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Target |
Mechanism LIV-1 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePreclinical |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Target- |
Mechanism LIV-1 inhibitors |
Active Org. ![]() |
Originator Org. ![]() |
Active Indication |
Inactive Indication- |
Drug Highest PhasePreclinical |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date01 Oct 2023 |
Sponsor / Collaborator |
Start Date29 Nov 2019 |
Sponsor / Collaborator |
Start Date09 Oct 2019 |
Sponsor / Collaborator ![]() [+1] |