Last update 08 May 2025

CIRBP

Basic Info

Synonyms
A18 hnRNP, A18HNRNP, CIRBP
+ [4]
Introduction
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

Analysis

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Hiro LS Researcher
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