GNB2

Last update 08 May 2025

Basic Info

Synonyms

G protein subunit beta 2, G protein subunit beta-2, GNB2

+ [2]

Introduction

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

100 Clinical Results associated with GNB2

100 Translational Medicine associated with GNB2

0 Patents (Medical) associated with GNB2

Literatures (Medical) associated with GNB2

01 Apr 2025·Progress in Neuro-Psychopharmacology and Biological Psychiatry

The underlying neurobiological basis of gray matter volume alterations in schizophrenia with auditory verbal hallucinations: A meta-analytic investigation

Review

Author: Zhang, Tian ; Guan, Muzhen ; Fang, Peng ; Xie, Yuanjun ; Wang, Huaning ; Li, Chenxi ; Wang, Lingling ; Ma, Chaozong ; Lin, Xinxin ; Wang, Zhongheng ; Li, Yijun

Schizophrenia patients with auditory verbal hallucinations (AVH) frequently exhibit brain structural alterations, particularly reductions in gray matter volume (GMV).Understanding the neurobiological mechanisms underlying the changes is essential for advancing treatment strategies. To address this, a meta-analysis was conducted to identify GMV changes in schizophrenia patients with AVH and their associations with gene expression and neurotransmitter receptor profiles. The results indicated significant GMV reductions in the left and the right insula, as well as the left anterior cingulate cortex. Ontology analysis of genes associated with GMV alternations revealed enrichment in biological processes related to ion transport and synaptic transmission. Hub genes from the KCN, SCN, GN, and PRK families, along with neurotransmitter receptors such as D2, VAChT, and mGluR5, showed significant correlations with GMV changes. Furthermore, multivariate linear regression analysis demonstrated that GNB2, GNB4, PRKCG, D2, and mGluR5 significantly predicted GMV alternations. These findings suggest that GMV reductions in schizophrenia with AVH are linked to disruptions in neurobiological processes involving specific genes and neurotransmitter systems, highlighting the potential targets for therapeutic intervention.

01 Feb 2025·Cancer Medicine

RETRACTION: LncRNA CCAT2 Promotes the Proliferation and Metastasis of Colorectal Cancer Through Activation of the ERK and Wnt Signaling Pathways by Regulating GNB2 Expression

Article

RETRACTION: J. Tian, X. Cao, Z. Jiang, J. Wang, W. Fan, S. Zhang, S. Zhao, and J. Sun, “LncRNA CCAT2 Promotes the Proliferation and Metastasis of Colorectal Cancer Through Activation of the ERK and Wnt Signaling Pathways by Regulating GNB2 Expression,” Cancer Medicine 13, no. 17 (2024): e70169, https://doi.org/10.1002/cam4.70169.The above article, published online on 03 September 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the authors; the journal Editor‐in‐Chief, Stephen Tait; and John Wiley & Sons Ltd. The authors reported to the journal that a third party had detected multiple overlapping panels within and between Figures 2 and 7 in this article. The authors further stated that, upon reviewing the published article, they discovered multiple issues related to image overlap and redundancy. All parties agree that the overlapping and duplicated images constitute a major error in the article and it must be retracted.

01 Sep 2024·Cancer Medicine

RETRACTED: LncRNA CCAT2 promotes the proliferation and metastasis of colorectal cancer through activation of the ERK and Wnt signaling pathways by regulating GNB2 expression

Article

Author: Zhao, Sien ; Zhang, Shaoting ; Fan, Wan ; Jiang, Zongying ; Sun, Jianmin ; Tian, Jinhai ; Cao, Xu ; Wang, Jia

AbstractBackgroundColorectal cancer (CRC) is a prevalent and lethal tumor, with metastasis being the leading cause of mortality. Previous research has indicated that the long non‐coding RNA (lncRNA) CCAT2 is involved in the regulation of various tumor progression mechanisms. However, the precise role of CCAT2 in CRC proliferation and metastasis remains ambiguous. This study seeks to elucidate the mechanisms through which CCAT2 influences CRC.MethodsHigh‐throughput sequencing and RT‐qPCR were used to detect CCAT2 expression in CRC. Functional analyses including CCK8, colony formation, wound healing migration, transwell chamber, and Muse® Cell Analyzer assays were performed to study the effects of CCAT2 gene deletion on CRC cells. RNA‐pulldown and protein mass spectrometry were employed to identify the interaction between CCAT2 and GNB2 protein.ResultsIncreased CCAT2 expression was found in CRC, especially in metastatic CRC. Deletion of CCAT2 gene inhibited CRC cell proliferation, migration, and invasion while promoting apoptosis. The interaction between CCAT2 and GNB2 protein was shown to modulate GNB2 protein alterations and affect the ERK and Wnt signaling pathways, thereby promoting CRC proliferation and metastasis.ConclusionCCAT2 plays a crucial role in CRC progression by modulating the ERK and Wnt signaling pathways through its interaction with GNB2. These findings highlight the importance of CCAT2 as a key regulatory element in the mechanisms underlying CRC proliferation and metastasis.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

GNB2

Basic Info

Related

Analysis