Last update 08 May 2025

GPR1

Basic Info

Synonyms
chemerin chemokine-like receptor 2, Chemerin-like receptor 2, Chemokine-like receptor 2
+ [4]
Introduction
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). (Microbial infection) Coreceptor for HIV-1.

Analysis

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