miR-29c

Last update 08 May 2025

Basic Info

Synonyms

hsa-mir-29c, microRNA 29c, MIR29C

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Introduction-

100 Clinical Results associated with miR-29c

100 Translational Medicine associated with miR-29c

0 Patents (Medical) associated with miR-29c

799

Literatures (Medical) associated with miR-29c

22 Apr 2025·Analytical Chemistry

Chemometrics-Assisted Enhancement of Electrochemical Biosensor Performance toward miRNA Detection

Article

Author: Esposito, Simona ; Cimmino, Wanda ; Kalligosfyri, Panagiota M. ; Iaccarino, Nunzia ; Cinti, Stefano

Chemometrics represents a potent tool for optimizing the experimental setup and subsequently boosting the performance of analytical methods. In particular, design of experiments (DoE) allows the experimental conditions to be optimized with high accuracy and a lower number of experiments when compared with the classical univariate approach, also known as one variable at a time (OVAT), which provides only a partial understanding on how factors affect the response. In this work, DoE was exploited, specifically a D-optimal design was used, to improve the analytical performance of a hybridization-based paper-based electrochemical biosensor, taking as target of the study the miRNA-29c (miR-29c) that is related to triple negative breast cancer. The sensing platform is composed of six variables to be optimized, including both those related to the sensor's manufacture (i.e., gold nanoparticles, immobilized DNA probe) and those related to the working conditions (i.e., ionic strength, probe-target hybridization, electrochemical parameters). The adoption of DoE allowed us to optimize the device using only 30 experiments with respect to the 486 that would have been required with the OVAT approach, and as a consequence of the more accurate optimal conditions that have been reached, the detection of miRNA was more sensitive and repeatable when compared with previous data reported using the univariate approach for optimization, leading to a 5-fold limit of detection (LOD) improvement toward miRNA. It confirms that chemometrics might be considered a fundamental tool to be used in the development of various kinds of sensors and biosensors.

01 Apr 2025·Neuroscience Bulletin

Pseudogene Lamr1-ps1 Aggravates Early Spatial Learning Memory Deficits in Alzheimer’s Disease Model Mice

Article

Author: Wang, Yuntai ; Chen, Wei ; Liu, Xiaojie ; Zeng, Zimeng ; Li, Hao ; Wu, Zhuoze

AbstractAlzheimer’s disease (AD), a neurodegenerative disorder with complex etiologies, manifests through a cascade of pathological changes before clinical symptoms become apparent. Among these early changes, alterations in the expression of non-coding RNAs (ncRNAs) have emerged as pivotal events. In this study, we focused on the aberrant expression of ncRNAs and revealed that Lamr1-ps1, a pseudogene of the laminin receptor, significantly exacerbates early spatial learning and memory deficits in APP/PS1 mice. Through a combination of bioinformatics prediction and experimental validation, we identified the miR-29c/Bace1 pathway as a potential regulatory mechanism by which Lamr1-ps1 influences AD pathology. Importantly, augmenting the miR-29c-3p levels in mice ameliorated memory deficits, underscoring the therapeutic potential of targeting miR-29c-3p in early AD intervention. This study not only provides new insights into the role of pseudogenes in AD but also consolidates a foundational basis for considering miR-29c as a viable therapeutic target, offering a novel avenue for AD research and treatment strategies.

01 Apr 2025·Clinical Rheumatology

Role of miRNAs in the pathogenesis of psoriasis and psoriatic arthritis: a genome-wide Mendelian randomization study

Article

Author: Li, Chanxiu ; Sun, Zhanxue

BACKGROUNDMicroRNAs (miRNAs) are critical in the onset and treatment of skin diseases, but the miRNAs causally associated with psoriasis (PSO) and psoriatic arthritis (PsA) remain unclear. This study aims to identify miRNAs with causal associations with PSO and PsA.METHODSFive Mendelian randomization (MR) methods were employed, using miRNA expression quantitative trait loci (mirQTL) data as exposure variables and PSO and PsA as outcome variables. This approach was used to uncover the causal links of miRNAs with both PSO and PsA, with robust sensitivity analyses ensuring the stability of our findings. Finally, miRNet and enrichment analyses were used to predict target genes of the causal miRNAs and their potential biological roles.RESULTSOur robust findings indicated that miR-27b-3p, miR-204-5p, and miR-6891-3p were notably associated with an enhanced risk of PSO. Additionally, miR-6891-3p was greatly associated with an enhanced risk of PsA. Conversely, miR-29c-3p, miR-181a-3p, miR-181a-5p, miR-181b-5p, and miR-199a-3p were substantially associated with a reduced risk of both PSO and PsA. Enrichment analyses revealed that the target genes of these causal miRNAs were markedly enriched in biological pathways such as apoptosis, Wnt, and PI3K-AKT signaling.CONCLUSIONThis study identifies eight miRNAs causally associated with PSO and five miRNAs associated with PsA, with no observed heterogeneity or pleiotropy. These findings offer potential biomarkers for the diagnosis and treatment of PSO and PsA. Key Points • We conducted the first genome-wide MR study to explore the causal relationships between miRNAs and PSO and PsA. • The study found stable and reliable causal effects of 8 miRNAs on PSO and 5 miRNAs on PsA. • These miRNAs provide important insights into elucidating the pathophysiological mechanisms of PSO and PsA and developing new therapeutic approaches.

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miR-29c

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