SLC50A1

Last update 08 May 2025

Basic Info

Synonyms

HsSWEET1, RAG1-activating protein 1, RAG1AP1

+ [11]

Introduction

Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.

100 Clinical Results associated with SLC50A1

100 Translational Medicine associated with SLC50A1

0 Patents (Medical) associated with SLC50A1

770

Literatures (Medical) associated with SLC50A1

31 Dec 2025·Annals of Medicine

Retinal and choroidal microvascular analysis by swept-source optical coherence tomography angiography in thyroid-associated ophthalmopathy (TAO) and hyperthyroidism without clinical signs of TAO

Article

Author: Cao, Tianyue ; Chen, Changzheng ; Hua, Dihao ; Liang, Congbi ; Liu, Jingcheng ; Xu, Yishuang ; Meng, Yang ; Chen, Zhen ; Xiao, Di ; Zheng, Hongmei

OBJECTIVETo analyse retinal and choroidal microvascular alterations in patients with thyroid-associated ophthalmopathy (TAO) and hyperthyroidism without signs of TAO using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate the potential reasons for ocular microvascular changes in patients with TAO.METHODSThirty patients with active TAO (group A), thirty patients with hyperthyroidism without signs of TAO (group B), and thirty healthy subjects (group C) were recruited. The images of macula and optic nerve head were obtained by SS-OCTA. Vessel density (VD) of superficial capillary plexus (SCP), deep capillary plexus, radial peripapillary capillary and choriocapillaris (CC), choroidal vascularity index, foveal avascular zone area, macular thickness, macular ganglion cell complex thickness, choroidal thickness (CT), and retinal nerve fibre layer thickness were measured.RESULTSGroup A had significantly higher VD of SCP than group C (all p < 0.05), and group B had significantly lower VD of SCP than group C (all p < 0.05). The VD of CC was significantly lower in group A than in groups B and C (p < 0.05). CT was significantly thicker in groups A and B than in group C (all p < 0.05). Multivariable regression analysis showed that the free triiodothyronine was significantly negatively correlated with the VD of SCP in the parafoveal regions in groups B and C (p < 0.05) and proptosis was significantly positively correlated with the VD of SCP in groups A and B (all p < 0.05).CONCLUSIONWe noted a difference in the VD of SCP and CC between patients with TAO and patients with hyperthyroidism without signs of TAO. These relative differences in ocular microvasculature indicated that local (orbital) and systemic (thyroid-related) factors may both play a role in disease presentation and progression, with orbital factors having a greater impact.

01 Jun 2025·Food Chemistry

Insights into effects of processing and food matrices on structure and ELISA detection of sarcoplasmic calcium binding protein

Article

Author: Li, Zhenxing ; Lin, Hang ; Huang, Yuhao ; Wang, Hao ; Gao, Xiang ; Liu, Qingwen ; Zhu, Wenye ; Lin, Hong

The sandwich ELISA (sELISA) targeting sarcoplasmic calcium binding protein (SCP) is significantly influenced by food matrices, yet the mechanisms are unclear. To clarify the comprehensive effects of environments, matrices, and processing, SCP treated with diverse temperatures, pH, and matrices was subjected to ELISA, electrophoresis, multispectroscopic and molecular simulation assays. Recoveries of sELISA and indirect competitive ELISA (icELISA) were inhibited above 80 °C and 100 °C due to the unfolding of SCP. Under acidic conditions, SCP became more compact improving icELISA while reducing sELISA. The tertiary structure, aggregation state of SCP, and ELISA results were primarily impacted by inorganic salts, carbohydrates, and peanut oil via non-covalent interactions. Slighter impacts of processing on icELISA suggested SCP might preserve epitopes maintaining antibody recognition. These findings elucidated the effects of various factors on SCP structure and the mechanisms behind variations in ELISA results, additionally demonstrating the stronger interference resistance of icELISA.

01 May 2025·Vaccine

Neutralizing antibodies against the Japanese encephalitis virus are produced by a 12 kDa E. coli- expressed envelope protein domain III (EDIII) tagged with a solubility-controlling peptide

Article

Author: Brindha, Subbaian ; Kurosu, Takeshi ; Inoue, Ayae ; Yoshizue, Takahiro ; Islam, M Monirul ; Tsurui, Hiromichi ; Kuroda, Yutaka ; Yesmin, Sanjida ; Islam, Md Din

Escherichia coli is a powerful and cost-effective platform for producing recombinant proteins. However, E. coli- produced proteins lack side-chain glycosylation and may be misfolded due to non-native disulfide bonds, often leading to poor immunogenicity. As a result, they are commonly perceived as unsuitable for use as antiviral vaccine antigens. This study addresses this challenge using the small 12 kDa envelope protein domain III of the Japanese encephalitis virus (JEV-EDIII) as a model. We demonstrate that the low immunogenicity of E. coli- produced proteins can be effectively overcome by employing a solubility-controlling peptide tag (SCP-tag) composed of five isoleucines (C5I). E. coli-produced JEV-EDIII oligomerized into 100 nm (Rh) soluble oligomers upon attachment of the C5I-tag, whereas the untagged JEV-EDIII remained monomeric (Rh ∼ 1.9 nm). The C5I-tag significantly enhanced anti-JEV EDIII IgG titers, as evidenced by ELISA, and increased the population of memory T cells in the spleen, as assessed by flow cytometry. Most notably, the C5I-tagged JEV-EDIII elicited neutralizing antibodies, confirmed by the FRNT₅₀ neutralization assay using live JEV. These findings suggest that oligomerization via SCP-tagging offers a promising, adjuvant-free approach for producing neutralizing antibodies with long-term T cell memory, paving the way for developing E. coli- produced, protein domain-based vaccines.

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SLC50A1

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