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Last update 08 May 2025

PB1

Last update 08 May 2025

Basic Info

Synonyms-

Introduction-

Drugs associated with PB1

US20230087825

Patent Mining

Target

CRBN x PB1 x PBRM1 x SMARCA1

Mechanism-

Active Org.

Kymera Therapeutics, Inc.

Originator Org.

Kymera Therapeutics, Inc.

Active Indication

Bone Diseases [+9]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PB1

100 Translational Medicine associated with PB1

0 Patents (Medical) associated with PB1

1,701

Literatures (Medical) associated with PB1

01 Jun 2025·Antiviral Research

Inhibition of influenza A virus proliferation in mice via universal RNA interference

Article

Author: Kuo, Chieh-Ying ; Chiu, Ya-Fang ; Kuo, Ming-Ling ; Chiang, Pei-Chuan ; Huang, Chung-Guei ; Kuo, Yu-Shen

Influenza A virus (IAV) is a respiratory pathogen that causes seasonal outbreaks and periodic pandemics. As frequent mutations in the IAV viral genome often render vaccines ineffective or inefficient in preventing the latest outbreak, there is a need to explore other preventive strategies to control the disease. This study sought to investigate the use of antiviral short hairpin RNA (shRNA), delivered by a recombinant adeno-associated virus (AAV), for the prevention of IAV infections. Conserved regions with less than 10 % of variation were identified from IAV genome sequences deposited in the National Center for Biotechnology Information (NCBI) database between 2000 and 2023. The shRNA targeting these conserved sequences was transcribed from the human RNA polymerase III U6 promoter in an AAV system. This study demonstrates that AAV delivery of shRNA against IAV genes encoding two of the viral RNA-dependent RNA polymerase subunits, PB1 and PB2, inhibits the replication of IAV H1N1 and H3N2 viruses in Madin-Darby canine kidney (MDCK) cells. Delivery of shPB1 to lung tissue in mice through AAV also provided effective protection against IAV infection. These results offer support for a shRNA-based strategy of influenza prevention.

01 May 2025·Archives of Virology

Avian influenza A(H5N6) virus detected during live-poultry market surveillance linked to a human infection in Changsha, China, from 2020 to 2023

Article

Author: Xu, Mingzhong ; Zhang, Rusheng ; Huang, Zheng ; Lu, Qing-Bin ; Li, Lingzhi ; Fu, Huiyuan ; Ou, Xinhua ; Xiao, Shan ; Yao, Dong ; Yang, Xuewen

In November 2022, we reported a fatal case of human infection caused by a highly pathogenic avian influenza A(H5N6) virus bearing a clade 2.3.4.4b HA gene in Changsha City. We investigated the transmission route and distribution of the H5N6 virus in the largest live-poultry market (LPM), which is linked to the human infection. A total of 1357 samples from the LPM were collected for avian influenza A virus detection from 2020 to 2023. The proportion of LPM samples positive for H5 subtype avian influenza virus was 14.30% (194/1357). Sequences of H5N6 (n = 10) and H5N1 (n = 4) avian influenza viruses were obtained from the LPM samples using next-generation sequencing. The complete genome sequence of the H5N6 virus from the human infection case, A/Changsha/1/2022(EPI_ISL_16466440), was determined and analyzed. The PB1 and PB2 segments shared 99.65% and 99.23% sequence identity with A/duck/Hunan/S40199/2021(H5N6) and A/Whooper swan/Sanmenxia/H615/2020(H5N8), respectively. The other segments showed the highest sequence similarity to strain A/Guangdong/1/2021(H5N6), which was isolated in Guangzhou. L89V and I292V substitutions in the PB2 protein were predicted from the A/Changsha/1/2022 genome sequence. Phylogenetic analysis based on the HA gene showed that A/Changsha/1/2022 and other H5 subtype isolates obtained from the LPM grouped together in the 2.3.4.4b branch. Bayesian evolutionary analysis of the HA gene showed that clade 2.3.4.4b of the H5N6 virus is likely to have been prevalent in Hunan Province around October 2021. In conclusion, we confirmed that the clade 2.3.4.4b HA gene of A/Changsha/1/2022 virus recombined with those of local strains. These results demonstrate the importance of continuous surveillance of H5N6 influenza viruses.

01 May 2025·International Journal of Biological Macromolecules

In-depth proteomic analysis of alfalfa silage inoculated with Lactiplantibacillus plantarum reveals protein transformation mechanisms and optimizes dietary nitrogen utilization

Article

Author: Zhang, Jiaqi ; Li, Huangkeyi ; Xia, Tianqi ; Yun, Fangfei ; Fu, Zhihui ; Jin, Sijie ; Teng, Kunling ; Zhong, Jin ; Liu, Shanji ; Sun, Jiahao ; Wang, Tianwei ; Wang, Siyue

Alfalfa is a vital feedstock for ruminants due to its high protein content. However, concerns regarding nitrogen (N) loss in alfalfa silage from protein transformation have arisen, but the underlying molecular mechanisms remain undefined. This study investigated the patterns of protein transformation in alfalfa during fermentation through multi-omics analysis. Lactiplantibacillus plantarum treatment effectively preserved the true protein PB1 and peptide-N, by mitigating N degradation. Proteomic profiling revealed a decrease in the abundance of higher molecular weight proteins (45-70 kDa), coupled with an increase in lower molecular weight proteins (15-45 kDa), mainly located in the membrane, cytoplasm and ribosome. Meanwhile, levels of protein hydrolysates, including peptides and essential amino acids, were elevated. Among these, Ile-Pro, Pro-Val, flavorful L-Glu and the proteogenic Arg were identified as the predominant constituents. Tripeptidyl-peptidase, carboxypeptidase, and serine protease were identified as the primary plant proteases mediating protein transformation. These findings highlight the synergistic effects of plant proteases and microbial activity, mainly from L. plantarum, in transforming large proteins into peptides and amino acids during fermentation. Our findings provide insights for the targeted regulation of alfalfa protein transformation during fermentation, potentially enhancing protein utilization in ruminants.

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PB1

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