FHL2

Last update 08 May 2025

Basic Info

Synonyms

DRAL, FHL-2, FHL2

+ [6]

Introduction

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).

100 Clinical Results associated with FHL2

100 Translational Medicine associated with FHL2

0 Patents (Medical) associated with FHL2

479

Literatures (Medical) associated with FHL2

01 Jun 2025·Materials Today Bio

Modeling a mesenchymal cell state by bioprinting for the molecular analysis of dormancy in melanoma

Article

Author: Arkudas, Andreas ; Bosserhoff, Anja K ; Schüle, Roland ; Metzger, Eric ; Fischer, Stefan ; Kengelbach-Weigand, Annika ; Kappelmann-Fenzl, Melanie ; El Ahmad, Zubeir ; Schmid, Rafael ; Hellerbrand, Claus ; Schmidt, Sonja K

Malignant melanoma is a highly aggressive tumor originating from the pigment producing cells, the melanocytes. It accounts for the majority of skin cancer related deaths worldwide. This is often due to the development of therapy resistance or tumor dormancy, eventually resulting in tumor relapse by yet undefined mechanisms. Tumor dormancy is thought to be mediated by the cellular microenvironment and models taking this factor into account are urgently needed. We 3D bioprinted melanoma cells in the hydrogels Cellink Bioink (CIB) or Matrigel (MG), each as a substitute of the extracellular matrix, and, thereby, induced a quiescent or a proliferative phenotype of the melanoma cell lines, respectively. RNA-Seq with subsequent comprehensive bioinformatical and molecular analyses assigned CIB-cultured cells to a predominantly mesenchymal and Matrigel-cultured cells to a more mitotic phenotype, emphasizing the CIB model as a suitable platform for the investigation of dormancy under consideration of the microenvironment. Melanoma cells in CIB 3D culture reflect a quiescent and migratory active cell state e.g. by revealing significant downregulation of genes associated with replication and cell cycle progression in this setting. Using this model system, we identified the mechanosensory gene FHL2 as one early sensor of changes in the ECM and suggest a FHL2-p21/AP-1 axis contributing to the dormant phenotype of melanoma cells in CIB.

01 Apr 2025·Forensic Science International

Reproducibility and validation of a targeted and flexible epigenetic clock for forensic applications

Article

Author: Paparazzo, Ersilia ; Lagani, Vincenzo ; Montesanto, Alberto ; Lagrotteria, Davide ; Falcone, Elena ; Aceto, Mirella Aurora ; Serra Cassano, Teresa ; La Russa, Antonella ; Passarino, Giuseppe ; Geracitano, Silvana ; Bruno, Francesco ; Bauleo, Alessia

DNA methylation variants have been widely used as biomarkers of ageing and several mathematical models have been developed to estimate the biological age. More recently, DNA technology has triggered efforts toward the simplification of the array-based epigenetic clocks and targeted approaches, based on the assessment of a small number of CpG sites have been developed. Among the markers included in these clocks, ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 resulted to be the most strongly validated markers. We tested the reproducibility and validation of a previously developed targeted epigenetic clock purposely optimized for the measurement of chronological age in blood samples. The clock includes DNAm biomarkers strongly correlated with chronological age whose DNA methylation levels were measured by using a multiplex methylation SNaPshot assay. We found that epigenetic age, calculated using the developed clock, was highly correlated with age (r = 0.97) in a total of 201 blood samples covering a full spectrum of human ages. For 74 of these, methylation profiles of the whole genome were obtained through the Infinium Methylation EPIC v2.0 Kit which also allowed to estimate the most frequently used clocks of Horvath. These results show the potential of our efficient and affordable test for simultaneously measuring DNA methylation levels at multiple target CpG sites to assess chronological age. We observed a strong correlation between the prediction models for the analyzed CpG sites measured using the SNaPshot method and those obtained with the Illumina EPIC array, especially with the Horvath2 clock, which was specifically developed for DNA from skin and blood cells.

01 Apr 2025·Molecular and Cellular Biochemistry

Unlocking the secrets of Cardiac development and function: the critical role of FHL2

Review

Author: Zeng, Qun ; Jiang, Tingting ; Wang, Jing

FHL2 (Four-and-a-half LIM domain protein 2) is a crucial factor involved in cardiac morphogenesis, the process by which the heart develops its complex structure. It is expressed in various tissues during embryonic development, including the developing heart, and has been shown to play important roles in cell proliferation, differentiation, and migration. FHL2 interacts with multiple proteins to regulate cardiac development as a coactivator or a corepressor. It is involved in cardiac specification and determination of cell fate, cardiomyocyte growth, cardiac remodeling, myofibrillogenesis, and the regulation of HERG channels. Targeting FHL2 has therapeutic implications as it could improve cardiac function, control arrhythmias, alleviate heart failure, and maintain cardiac integrity in various pathological conditions. The identification of FHL2 as a signature gene in atrial fibrillation suggests its potential as a diagnostic marker and therapeutic target for this common arrhythmia.

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FHL2

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