NKX2-2

Last update 08 May 2025

Basic Info

Synonyms

Homeobox protein NK-2 homolog B, Homeobox protein Nkx-2.2, NK2 homeobox 2

+ [3]

Introduction

Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).

100 Clinical Results associated with NKX2-2

100 Translational Medicine associated with NKX2-2

0 Patents (Medical) associated with NKX2-2

662

Literatures (Medical) associated with NKX2-2

01 Apr 2025·Virchows Archiv

Sinonasal EWSR1::POU2AF3 sarcoma: a case report and literature review

Review

Author: Bilgiç, Bilge ; Bakkaloğlu, Doğu Vurallı ; Yılmaz, İsmail ; Çetin, Sırma ; Çelik, Mehmet ; Özlük, Yasemin

We present the clinicopathologic and molecular characteristics of a rare sinonasal sarcoma with undifferentiated round cell and spindle morphology, defined by the EWSR1::POU2AF3 fusion. A 62-year-old male presented with nasal congestion. A polypoid lesion excised from the sinonasal cavity was initially diagnosed as 'glomangiopericytoma' at an external center, but recurred and was referred to our clinic four years later. Histopathological evaluation of primary and recurrent tumors showed pleomorphic spindle and round cell morphology with prominent nucleoli and thin-walled hemangiopericytomatous vessels. CD99 (MIC2) and CD117 (CKIT) were diffuse positivite while ß-catenin showed cytoplasmic/membranous expression. Pancytokeratin and EMA were focally positive. NKX2.2, DUX4, ETV4, BCOR, CCNB3, SS18-SSX, STAT6, CD34, and others were all negative. Next generation sequencing confirmed EWSR1::POU2AF3 fusion. This case exemplifies a rare, aggressive sinonasal sarcoma with EWSR1::POU2AF3 fusion, emphasizing its distinct morphology and challenging behaviour.

01 Apr 2025·Urology

Pelvic Mass in a Pediatric Patient: A Rare Case of Extraosseous Ewing Sarcoma

Article

Author: Stanasel, Irina ; Attia, Sarah ; Carolan, Alexandra ; Dalela, Deepansh ; Batie, Shane ; Rakheja, Dinesh

Ewing sarcoma (ES) is a common malignant bone tumor in children, but primary extraosseous Ewing sarcoma (EES) in the pelvic region is particularly rare. We report a 21-month-old male with a 10-cm complex cystic mass adherent to the bladder. Core biopsy demonstrated a small round cell neoplasm positive for CD99, NKX2-2, and EWSR1:ERG fusion. The patient had a residual mass following induction chemotherapy, and underwent surgical resection with anterior detrusorrhaphy with no other pelvic organ involvement. Pathology showed <10% residual tumor with negative margins. Following completion of consolidation chemotherapy, imaging has shown no evidence of recurrent disease 13 months post-surgery.

01 Apr 2025·Developmental Biology

Shh signaling directs dorsal ventral patterning in the regenerating X. tropicalis spinal cord

Article

Author: Angell Swearer, Avery ; Perkowski, Samuel ; Wills, Andrea

Tissue development and regeneration rely on the deployment of embryonic signals to drive progenitor activity and thus generate complex cell diversity and organization. One such signal is Sonic Hedgehog (Shh), which establishes the dorsal-ventral (D/V) axis of the spinal cord during embryogenesis. However, the existence of this D/V axis and its dependence on Shh signaling during regeneration varies by species. Here we investigate the function of Shh signaling in patterning the D/V axis during spinal cord regeneration in Xenopus tropicalis tadpoles. We find that neural progenitor markers Msx1/2, Nkx6.1, and Nkx2.2 are confined to dorsal, intermediate and ventral spatial domains, respectively, in both the uninjured and regenerating spinal cord. These domains are altered by perturbation of Shh signaling. Additionally, we find that these D/V domains are more sensitive to Shh perturbation during regeneration than uninjured tissue. The renewed sensitivity of these neural progenitor cells to Shh signals represents a regeneration specific response and raises questions about how responsiveness to developmental patterning cues is regulated in mature and regenerating tissues.

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NKX2-2

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