SERPINE2

Last update 23 Jan 2025

Basic Info

Synonyms

GDN, Glia-derived nexin, nexin

+ [11]

Introduction

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

100 Clinical Results associated with SERPINE2

100 Translational Medicine associated with SERPINE2

0 Patents (Medical) associated with SERPINE2

971

Literatures (Medical) associated with SERPINE2

31 Dec 2025·Annals of Medicine

Predictive value of three nutritional indexes for disease activity in patients with inflammatory bowel disease

Article

Author: Zhang, Xiangting ; Ying, Kanglei ; Wu, Xiao ; Song, Xian ; Zeng, Yuan ; Zhou, Ruoru ; Yu, Fujun ; Xu, Qian ; Cai, Weimin ; Chen, Yuhao ; Zhao, Luying ; Xu, Jun ; Chen, Zhuoyan ; Zeng, Liuwei ; Ying, Huiya

BACKGROUNDMalnutrition is prevalent in patients with inflammatory bowel disease (IBD); however, its ability to predict the disease activity in IBD remains unexplored. Therefore, this study aimed to explore the association between malnutrition and disease activity in IBD.METHODSIn this retrospective study, we enrolled 1006 patients diagnosed with IBD from the First Affiliated Hospital of Wenzhou Medical University from 2011 to 2022. Malnutrition was assessed based on the prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI), and controlling nutritional status (CONUT) scores. Logistic regression analyses were performed to identify predictors for disease activity. Restricted cubic spline analysis was performed to evaluate the possible nonlinear relations, and subgroup analysis was performed to explore potential interactions. Additionally, prediction performances were compared through receiver operating characteristic curves, net reclassification improvement, and integrated discrimination improvement.RESULTSThe prevalence of malnutrition calculated by the PNI, GNRI, and CONUT scores in IBD was 16.9%, 72.1%, and 75.6%, respectively and significant correlations were observed among them. Multivariate logistic regression analysis showed that PNI, GNRI, and CONUT were independent risk factors for disease activity, and no significant nonlinear relationship was observed between disease activity and all three indexes. No statistically significant interactive effect was found in nearly all the subgroups. GNRI showed the highest predictive value compared with PNI and CONUT. Additionally, combining any of the three indexes improved the ability of C-reactive protein to predict IBD activity.CONCLUSIONSAll three nutritional indexes evaluated malnutrition to be an independent risk factor for IBD activity.

01 Feb 2025·Diabetes, Obesity and Metabolism

Integrative transcriptome analysis reveals Serpine2 promotes glomerular mesangial cell proliferation and extracellular matrix accumulation via activating ERK1/2 signalling pathway in diabetic nephropathy

Article

Author: Dai, Zhe ; Li, Xin ; Xiang, Hongyu ; Zheng, Ting ; Yang, Ruhao

AbstractBackgroundDiabetic nephropathy (DN) is one of the main causes of end‐stage renal disease (ESRD), but its mechanism has not been clearly studied. We utilized integrative transcriptome analysis to explore the pathogenesis of DN.MethodsWe conducted an analysis by combining bulk dataset and single‐cell transcriptome dataset. Through this approach, we identified that Serpine2 may regulate the ‘collagen‐containing extracellular matrix’ pathway involved in DN. Subsequently, we established DN animal and cell models using db/db mice and mesangial cells (MCs) to validate the role of Serpine2 in DN. In the animal model, we detected the expression level of Serpine2 in DN using western blotting (WB) and immunofluorescence (IF) assays. To further clarify the molecular mechanism of Serpine2 in DN, we knocked down Serpine2 and observed its effects on MCs proliferation and extracellular matrix (ECM) accumulation.ResultsOur single‐cell analysis of DN models highlighted a pivotal role for MCs in the disease's initiation. Next, through Cytoscape analysis of differentially expressed genes (DEGs) in MCs, we identified the following 10 hub genes: Acta2, Angpt2, Ccn1, Col4a1, Col4a2, Col8a1, Kdr, Thbs1, Tpm4 and Serpine2. Subsequently, we identified that Serpine2 and Kdr were also significantly DEGs in the bulk analysis of glomeruli. Additionally, our integrated gene set enrichment analysis of bulk dataset and single‐cell RNA dataset revealed that the ‘collagen‐containing extracellular matrix’ was a key pathway in DN progression. Serpine2 was one of the crucial genes involved in regulating this pathway. Therefore, we speculated that the regulation of the ‘collagen‐containing extracellular matrix’ pathway by Serpine2 was an important mechanism. Importantly, WB and IF staining confirmed that Serpine2 expression was upregulated in the MCs of diabetic mice. Knockdown of Serpine2 in cultured MCs alleviated high‐glucose‐induced excessive MCs proliferation and ECM accumulation. Finally, we found that ERK agonist Ro 67‐7476 eliminated the effect of Serpine2 siRNA.ConclusionsIn summary, Serpine2 regulates MCs proliferation and ECM synthesis through activation of the ERK1/2 pathway, which is an important pathogenesis mechanism of DN. These findings offer fresh perspectives on the mechanisms of glomerulosclerosis in DN pathogenesis and may provide new targets for treating DN.

01 Feb 2025·Cancer Letters

Corrigendum to “SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer” [Cancer Lett. 524 (2022) 268–283]

Author: Chen, Xueqin ; Wu, Kan ; Ma, Shenglin ; Xu, Yasi ; Zhang, Shirong ; Xie, Shujun ; Yang, Yuhong ; Zhu, Lucheng ; Zhang, Jingjing ; Wang, Yuqing ; Zhao, Yanyan ; Wu, Qiong ; Tu, Linglan

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