CYB5R1

Last update 08 May 2025

Basic Info

Synonyms

b5R.1, CYB5R1, cytochrome b5 reductase 1

+ [4]

Introduction

NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

100 Clinical Results associated with CYB5R1

100 Translational Medicine associated with CYB5R1

0 Patents (Medical) associated with CYB5R1

Literatures (Medical) associated with CYB5R1

30 Aug 2024·Medicine

Identification of cuproptosis-related genes related to the progression of ankylosing spondylitis by integrated bioinformatics analysis

Article

Author: Chen, Ting ; Fan, Junyi ; Liu, Qihua ; Chen, Yongbin ; Wu, Junzhe

Ankylosing spondylitis (AS) is an autoimmune disease, and the relationship between copper death and AS is not clear. The aim of this study was to analyze and identify potential cuprosis-related genes associated with the onset of AS by bioinformatics methods. We obtained the AS gene expression profile GSE25101 from the Gene Expression Omnibus (GEO) database, which consists of blood samples from 16 active AS patients and 16 sex-and age-matched controls. After analyzing the data, we utilized the WGCNA method to identify genes that exhibited significant differential expression. In order to assess the prognostic and predictive power of these genes, we constructed receiver operating characteristic (ROC) curves. To further validate our predictions, we employed nomograms, calibration curves, decision curve analysis, and external datasets. Lastly, we conducted an analysis on immune infiltration and explored the correlation between key genes and immune response. Three genes, namely INPP5E, CYB5R1, and HGD, have been identified through analysis to be associated with AS. The diagnosis of patients using these genes has been found to possess a high level of accuracy. The area under the ROC curve is reported to be 0.816 for INPP5E, 0.879 for CYB5R1, and also 0.879 for HGD. Furthermore, the nomogram demonstrates an excellent predictive power, and it has been calibrated using a Calibration curve. Its clinical usefulness and net benefit have been thoroughly analyzed and estimated through the use of a DCA curve. Moreover, INPP5E, CYB5R1, and HGD are found to be associated with various types of immune cells. In conclusion, the systematic analysis of cuprosis-related genes may aid in the identification of mechanisms related to copper-induced cell death in AS and offer valuable biomarkers for the diagnosis and treatment of AS.

01 Apr 2024·Veterinary Research Communications

Elucidation of novel SNPs affecting immune response to classical swine fever vaccination in pigs using immunogenomics approach

Article

Author: Bharati, Jaya ; Chaudhary, Rajni ; Karthikeyan, A ; Gaur, G K ; Dutt, Triveni ; Panigrahi, Manjit ; Kaiho, Kaisa ; Kumari, Soni ; Bhushan, Bharat ; Kumar, Satish ; Kumar, Amit ; Banik, Santanu

The host genetic makeup plays a significant role in causing the within-breed variation among individuals after vaccination. The present study was undertaken to elucidate the genetic basis of differential immune response between high and low responder Landlly (Landrace X Ghurrah) piglets vis-à-vis CSF vaccination. For the purpose, E2 antibody response against CSF vaccination was estimated in sampled animals on the day of vaccination and 21-day post-vaccination as a measure of humoral immune response. Double-digestion restriction associated DNA (ddRAD) sequencing was undertaken on 96 randomly chosen Landlly piglets using Illumina HiSeq platform. SNP markers were called using standard methodology. Genome-wide association study (GWAS) was undertaken in PLINK program to identify the informative SNP markers significantly associated with differential immune response. The results revealed significant SNPs associated with E2 antibody response against CSF vaccination. The genome-wide informative SNPs for the humoral immune response against CSF vaccination were located on SSC10, SSC17, SSC9, SSC2, SSC3 and SSC6. The overlapping and flanking genes (500Kb upstream and downstream) of significant SNPs were CYB5R1, PCMTD2, WT1, IL9R, CD101, TMEM64, TLR6, PIGG, ADIPOR1, PRSS37, EIF3M, and DNAJC24. Functional enrichment and annotation analysis were undertaken for these genes in order to gain maximum insights into the association of these genes with immune system functionality in pigs. The genetic makeup was associated with differential immune response against CSF vaccination in Landlly piglets while the identified informative SNPs may be used as suitable markers for determining variation in host immune response against CSF vaccination in pigs.

01 Jan 2024·Translational Oncology

CYB5R1 is a potential biomarker that correlates with stemness and drug resistance in gastric cancer

Article

Author: Yan, Yongfeng ; Ma, Yufan ; Zhang, Qin ; Zhang, Lu ; Zhang, Yajun

BACKGROUNDDrug resistance is a major obstacle in the treatment of gastric cancers (GC). In recent years, the prognostic value of the mRNA expression-based stemness score (mRNAss) across cancers has been reported. We intended to search for the key genes associated with Cancer stem cells (CSCs) and drug resistance.METHODSAll GC samples from The Cancer Genome Atlas (TCGA) were then divided into low- and high-mRNAss groups based on the median value of mRNAss. A weighted correlation network analysis (WCGNA) was used to identify co-expressed genes related to mRNAss groups. Differential gene expression analysis with Limma was performed in the GSE31811. The correlations between CYB5R1 and the immune cells and macrophage infiltration were analyzed by TIMER database. Spheroid formation assay was used to evaluate the stemness of gastric cancer cells, and transwell assay was used to detect the invasion and migration ability of gastric cancer cells.RESULTSGC patients with high mRNAss values had a worse prognosis than those with low mRNAss values. 584 genes were identified by WGCNA analysis. 668 differentially expressed genes (DEGs) (|logFC|>1) with 303 down-regulated and 365 up-regulated were established in drug-effective patients compared to controls. TCGA-STAD samples were divided into 3 subtypes based on 303 down-regulated genes. CYB5R1 was a potential biomarker that correlated with the response to drugs in GC (AUC=0.83). CYB5R1 participated in drug resistance and tumorigenesis through NFS1 in GC.CONCLUSIONSOur study highlights the clinical importance of CYB5R1 in GC and the CYB5R1-NFS1 signaling-targeted therapy might be a feasible strategy for the treatment of GC.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

CYB5R1

Basic Info

Related

Analysis