SYBU

Last update 08 May 2025

Basic Info

Synonyms

FLJ20366, Golgi-localized syntaphilin-related protein, GOLSYN

+ [6]

Introduction

Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.

100 Clinical Results associated with SYBU

100 Translational Medicine associated with SYBU

0 Patents (Medical) associated with SYBU

Literatures (Medical) associated with SYBU

01 Jan 2024·Nature GeneticsQ1 · BIOLOGY

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

Q1 · BIOLOGY

Article

Author: Guo, Jifeng ; Dean, Marissa ; Brice, Alexis ; Doquenia, Maria Leila ; Serrano, Geidy E. ; Beyer, Katrin ; Stefanis, Leonidas ; Mok, Kin Ying ; Hoenicka, Janet ; Lange, Lara M. ; Pastor, Pau ; Shulman, Joshua ; Avenali, Micol ; Kaishibayeva, Gulnaz ; Tat, Susana A. ; Murad, Nor Azian Abdul ; Ojo, Oluwadamilola ; Sanyaolu, Arinola ; Murphy, Kaileigh ; Weldon, Catherine H. ; Rizig, Mie ; Espay, Alberto ; Sharma, Manu ; Iakovenko, Elena ; Hadjigorgiou, Georgios ; Alcalay, Roy ; Shang, Huifang ; Ahmad-Annuar, Azlina ; Wegel, Claire ; Hopfner, Franziska ; Sassi, Samia Ben ; Salari, Mehri ; Stott, Simon ; Rodriguez-Violante, Mayela ; Walker, Ruth ; Pihlstrøm, Lasse ; Tay, Yi Wen ; Arboleda, Gonzalo ; Karimova, Altynay ; Ertan, Sibel ; Riley, Ekemini ; Jewett, Ethan M. ; Wong, Corinna D. ; Pal, Pramod ; Alvarez, Ignacio ; Vitale, Dan ; Dumanis, Sonya ; Bandres-Ciga, Sara ; Tang, Beisha ; Klein, Christine ; Monchi, Oury ; Koretsky, Mathew ; Williams, Nigel ; Kauffman, Marcelo ; Cubo, Esther ; Periñan, Maria Teresa ; Heilbron, Karl ; Höglinger, Günter ; Obese, Vida ; Galleguillos, Benjamin Pizarro ; Zhou, Xiaopu ; Screven, Laurel ; Reyes-Pérez, Paula ; Noyce, Alastair J. ; Kumar, Kishore ; Partida, Gabriel Cuellar ; McCreight, Jey C. ; Schloetter, Madeleine ; Aasly, Jan O. ; Akpalu, Albert ; Gatto, Emilia M. ; Kaiyrzhanov, Rauan ; Schirinzi, Tommaso ; Tavadyan, Zaruhi ; Su, Qiaojuan Jane ; Brolin, Kajsa ; Albin, Roger ; Divya, K. P. ; El-Sadig, Sarah ; Okubadejo, Njideka ; Çakmak, Özgür Öztop ; Dadiotis, Efthymios ; Coker, Daniella ; Bustamante, Maria Leonor ; Awad, Paula Saffie ; Aslibekyan, Stella ; Singleton, Andrew B. ; Hernandez, Alvaro ; Cheung, Nelson Yuk-Fai ; Kim, Jonggeol Jeffrey ; Cannon, Paul ; Dagklis, Ioannis ; Tchakouté, Christophe Toukam ; Miranda, Marcelo ; Leonard, Hampton ; Fon, Ted ; Okunoye, Olaitan ; Hunter, Julie ; Siddiqi, Bernadette ; Wood, Nicholas ; Nguyen, Duan ; Morris, Huw R. ; Ur-Rehman, Shoaib ; Noblin, Elizabeth S. ; Shiraishi, Tomotaka ; Atadzhanov, Masharip ; Medina, Alex ; Petrakovitz, Aaron A. ; Lake, Julie ; Krack, Paul ; Krüger, Rejko ; Mata, Ignacio ; Bale, Claire ; Trinh, Joanne ; Tinkhauser, Gerd ; Chowdhury, Sohini ; Hattori, Nobutaka ; Wang, Xin ; Orozc, Jorge ; Quattrone, Andrea ; Mata, Ignacio F. ; Mollenhauer, Brit ; Chan, Phillip ; Illarionova, Anastasia ; Carroll, Camille ; Jonas, Cabell ; Zewde, Yared Z. ; Inca-Martinez, Miguel ; Eriksson, Nicholas ; Kukkle, Prashanth Lingappa ; Wu, Hsiu-Chuan ; Jiang, Yunxuan ; Nuytemans, Karen ; Genc, Gencer ; Tarnanas, Ioannis ; Levine, Kristin S. ; Xie, Tao ; Song, Yeajin ; Pitcher, Toni L. ; Vollstedt, Eva-Juliane ; Lohmann, Katja ; Madoev, Harutyun ; Lowe, Maya ; Nguyen, Toan ; Beach, Thomas ; Marek, Kenneth ; Sobering, Andrew K. ; Shringarpure, Suyash ; Louie, Naomi ; Llamas, Bianca A. ; Tan, Manuela ; Stafford, Eleanor J. ; Vinuela, Angel ; Carr, Jonathan ; McIntyre, Matthew H. ; Rieder, Carlos ; Puckelwartz, Megan J. ; Fitch, Alison ; Khachatryan, Samson ; Sarmiento, Ignacio Juan Keller ; Cruchaga, Carlos ; Kieburtz, Karl ; Reynoso, Alexandra ; Stamelou, Maria ; Kukar, Katelyn ; Chen, Honglei ; Kwong, Alan ; Lin, Keng-Han ; Love, Seth ; Fang, Zih-Hua ; Pantazis, Caroline B. ; Fletez-Brant, Kipper ; Martinez-Ramirez, Daniel ; Martínez-Carrasco, Alejandro ; Dey, Sumit ; Nandakumar, Priyanka ; Shepherd, Claire E. ; Borgohain, Rupam ; Filshtein, Teresa ; Schumacher-Schuh, Artur F. ; Nguyen, Dominique T. ; Kamel, Walaa A. ; Luo, Wei ; Kung, Pin-Jui ; Bielenberg, Jessica ; Bell, Robert K. ; Chana, Pedro ; Nalls, Mike A. ; Lian, Michelle Mulan ; O’Grady, Alyssa ; Poznik, G. David ; Tserensodnom, Bayasgalan ; Tran, Vinh ; Parnetti, Lucilla ; Kim, Yun Joong ; Weil, Rimona ; Amouri, Rim ; Valente, Enza Maria ; Jeon, Beomseok ; Houlden, Henry ; Auton, Adam ; Groppa, Sergiu ; Kuhl, Maggie ; Cornejo-Olivas, Mario ; del Rio, Marlene Jimenez ; Grosset, Donald ; Amod, Ferzana ; Koks, Sulev ; Junker, Johanna ; Chan, Piu ; Shastri, Anjali J. ; Babalola, Elizabeth ; Ojha, Rajeev ; Wu, Yihru ; Ip, Nancy ; Solsberg, Caroline Warly ; Norlinah, Mohamed Ibrahim ; Foo, Jia Nee ; Bardien, Soraya ; Rosales, Raymond ; Hardy, John ; Jankovic, Joseph ; Camargos, Sarah ; Kishore, Asha ; Bullis, Emily ; Hernandez, Dena ; Fontanillas, Pierre ; Granka, Julie M. ; Azmin, Shahrul ; Faghri, Faraz ; Tan, Ai Huey ; Shambetova, Cholpon ; Mubarak, Bashayer Al ; Lubbe, Steven ; Tan, Eng-King ; Başak, A. Nazl ; Schrag, Anette ; Zimprich, Alexander ; Hall, Deborah ; Xiromerisiou, Georgia ; Wang, Wei ; Chan, Germaine Hiu-Fai ; Sherer, Todd ; Fiske, Brian ; Veliz-Otani, Diego ; Umair, Muhammad ; Ruffrage, Lauren ; Schumacher, Morgan ; Freyman, Will ; Tung, Joyce Y. ; Lim, Shen-Yang ; Chahine, Lana M. ; Hicks, Barry ; Schapira, Anthony ; O’Connell, Jared ; Das, Sayantan ; Wu, Ruey-Meei ; Funayama, Manabu ; Gasser, Thomas ; Zweier, Christiane ; Jasaityte, Simona ; Marsili, Luca ; Bryc, Katarzyna ; Rajan, Roopa ; Wilton, Peter ; Anderson, Tim J. ; Hinds, David A. ; Mencacci, Niccolò Emanuele ; Otani, Diego Véliz ; Shi, Jingchunzi ; Fon, Edward A. ; Dhamija, Devika ; Ibanez, Laura ; Mohamed, Wael ; Casey, Bradford ; Solle, Justin C. ; Shelton, Janie F. ; Ellis, Melina ; Rentería, Miguel E. ; Micheletti, Steven J. ; Shiamim, Ejaz ; Corvol, Jean-Christophe ; Tumas, Vitor ; Blauwendraat, Cornelis ; Moreno, Meghan E. ; Makarious, Mary B. ; Markopoulou, Katerina ; Foroud, Tatiana ; Olguin, Patricio ; Comart, Charisse ; Lewis, Patrick Alfryn ; Shulman, Lisa ; Hernandez, Alejandro ; Westenberger, Ana ; Elson, Sarah L. ; Williamson, Jared ; Lin, Chin-Hsien ; Iwaki, Hirotaka ; Salama, Mohamed

AbstractAlthough over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations.

01 May 2021·Molecular PsychiatryQ1 · MEDICINE

Defects in syntabulin-mediated synaptic cargo transport associate with autism-like synaptic dysfunction and social behavioral traits

Q1 · MEDICINE

Article

Author: Li, Sunan ; Cheng, Xiu-Tang ; Huang, Ning ; Sun, Tao ; Xiong, Gui-Jing ; Sheng, Zu-Hang ; Xie, Yuxiang ; Lin, Mei-Yao

The formation and maintenance of synapses require long-distance delivery of newly synthesized synaptic proteins from the soma to distal synapses, raising the fundamental question of whether impaired transport is associated with neurodevelopmental disorders such as autism. We previously revealed that syntabulin acts as a motor adapter linking kinesin-1 motor and presynaptic cargos. Here, we report that defects in syntabulin-mediated transport and thus reduced formation and maturation of synapses are one of core synaptic mechanisms underlying autism-like synaptic dysfunction and social behavioral abnormalities. Syntabulin expression in the mouse brain peaks during the first 2 weeks of postnatal development and progressively declines during brain maturation. Neurons from conditional syntabulin^-/- mice (stb cKO) display impaired transport of presynaptic cargos, reduced synapse density and active zones, and altered synaptic transmission and long-term plasticity. Intriguingly, stb cKO mice exhibit core autism-like traits, including defective social recognition and communication, increased stereotypic behavior, and impaired spatial learning and memory. These phenotypes establish a new mechanistic link between reduced transport of synaptic cargos and impaired maintenance of synaptic transmission and plasticity, contributing to autism-associated behavioral abnormalities. This notion is further confirmed by the human missense variant STB-R178Q, which is found in an autism patient and loses its adapter capacity for binding kinesin-1 motors. Expressing STB-R178Q fails to rescue reduced synapse formation and impaired synaptic transmission and plasticity in stb cKO neurons. Altogether, our study suggests that defects in syntabulin-mediated transport mechanisms underlie the synaptic dysfunction and behavioral abnormalities that bear similarities to autism.

01 Sep 2018·Developmental BiologyQ3 · BIOLOGY

Maternal genetic effects in Astyanax cavefish development

Q3 · BIOLOGY

Article

Author: Shi, Janet ; Yoshizawa, Masato ; Jeffery, William R ; Parkhurst, Amy ; Strickler, Allen G ; Ma, Li

The role of maternal factors in the evolution of development is poorly understood. Here we describe the use of reciprocal hybridization between the surface dwelling (surface fish, SF) and cave dwelling (cavefish, CF) morphs of the teleost Astyanax mexicanus to investigate the roles of maternal genetic effects in cavefish development. Reciprocal hybridization, a procedure in which F1 hybrids are generated by fertilizing SF eggs with CF sperm (SF × CF hybrids) and CF eggs with SF sperm (CF × SF hybrids), revealed that the CF degenerative eye phenotype showed maternal genetic effects. The eyes of CF × SF hybrids resembled the degenerate eyes of CF in showing ventral reduction of the retina and corresponding displacement of the lens within the optic cup, a smaller lens and eyeball, more lens apoptosis, a smaller cartilaginous sclera, and lens-specific gene expression characteristics compared to SF × CF hybrids, which showed eye and lens gene expression phenotypes resembling SF. In contrast, reciprocal hybridization failed to support roles for maternal genetic effects in the CF regressive pigmentation phenotype or in CF constructive changes related to enhanced jaw development. Maternal transcripts encoded by the pou2f1b, runx2b, and axin1 genes, which are involved in determining ventral embryonic fates, were increased in unfertilized CF eggs. In contrast, maternal mRNAs encoded by the ß-catenin and syntabulin genes, which control dorsal embryonic fates, showed similar expression levels in unfertilized SF and CF eggs. Furthermore, maternal transcripts of a sonic hedgehog gene were detected in SF and CF eggs and early cleaving embryos. This study reveals that CF eye degeneration is controlled by changes in maternal factors produced during oogenesis and introduces A. mexicanus as a model system for studying the role of maternal changes in the evolution of development.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

SYBU

Basic Info

Related

Analysis