HDGFL2

Reaffirming innovation as an AI-based digital microscope while presenting new malaria data at the annual meeting of the ASTMH 2023 Noul's 'miLab™' showed significantly higher sensitivity than that of microscopy in health centers YONGIN, South Korea, Oct. 23, 2023 /PRNewswire/ -- Noul Co., Ltd., (376930.KR), an Artificial Intelligence (AI) based blood and cancer diagnostic platform company, unveiled the results of a clinical study conducted by miLab™ in two African countries. Noul participated in the American Society of Tropical Medicine and Hygiene (ASTMH) Annual Meeting 2023 held from October 18th to 22nd, in Chicago, USA. Continue Reading Dr. Cristian Koepfli, Professor of the University of Notre Dame is presenting the result of malaria diagnosis using miLab™. In a lightning talk and at the poster session held on October 20th, Dr. Cristian Koepfli from University of Notre Dame, USA, presented the key results of a clinical performance study on Noul's miLab™ in collaboration with scientists from Gondar University, Ethiopia, Kwame Nkrumah University of Science and Technology, Ghana, and Noul. In the study unveiled by the poster titled "A digital microscope for the diagnosis of Plasmodium falciparum and Plasmodium vivax parasites, including P. falciparum with hrp2/hrp3 deletion", a total of 1,649 patients enrolled in Gondar, Ethiopia, and Kumasi, Ghana were tested. In the study, the scientists compared the sensitivity and specificity of the qPCR with those of miLab™, field microscopy, and Rapid Diagnostic Test (RDT) respectively. Diagnosis of P. falciparum infections included cases with hrp2/hrp3 gene deletion with renders parasites 'invisible' to common rapid diagnostic tests. To summarize the result, miLab™ reached a sensitivity of 94.3% and a specificity of 94% for P. falciparum diagnosis and a sensitivity of 97% and a specificity of 97.6% for P. vivax diagnosis. Diagnoses for both species showed significantly higher sensitivity and specificity of the miLab™ compared to field microscopy tests. Also, the diagnostic results of miLab™ in P. falciparum infected patients with hrp2/hrp3 gene deletion have been released. The miLab™ diagnosed 51 out of 52 P. falciparum infections with hrp2 deletion. The deletion of hrp2/3 gene is a key issue in diagnosing P. falciparum malaria infection, especially in areas with high prevalence of the deletion, which increases the need for innovative diagnostic methods such as miLab™. Dr. Cristian Koepfli, Professor of University of Notre Dame, said "Also in diagnosis, 'seeing is believing'. The ability and reliability of the miLab™ to show the parasite on a screen is a major benefit over other diagnostic methods. This new study in Ethiopia and Ghana confirmed the clinical performance of miLab™ as a reliable new tool in the diagnosis of P. falciparum and P. vivax malaria. We expect the potential to address the global challenge of malaria diagnosis, including the high applicability of miLab™ in diagnosing parasites with the deletion of the hrp2/3 genes." The results of the study presented at the poster session by Dr.Cristian Koepfli will be published in an international scientific journal. Dr. Taehwan Kim, Managing Director of noul GmbH (Noul Europe) said, "Noul's miLab™ is an innovative digital microscope technology that attracts the attention of the international community as a cost-effective diagnostic device in countries with high malaria incidence. Noul will fulfill the market's expectation by accumulating and making public reliable data on miLab™, as well as develop business opportunities in tropical infectious diseases, that have been among Noul's areas of interest, on top of the fully commercialized malaria diagnosis." Noul's miLab™ is highly recognized by the international community for its innovations in the field of blood and tissue diagnosis. It was introduced as the most advanced digital microscope and fully integrated bench-top platform in the 2022 annual report of UNITAID, an international drug and diagnostic device purchase facility. In March 2023, Noul commenced the R&D for supporting malaria control with the RIGHT Foundation (Research Investment for Global Health Technology), an international public-private partnership funding agency that supports global health R&D, to undertake a three-year clinical trial and cost-effectiveness analysis of malaria products. At the annual meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), Noul explored opportunities for building public health networks and business collaboration through the exhibition booth to introduce miLab™ and its malaria and cervix products. ASTMH, the world's largest public health society that has a history of 120 years, strives to propagate the global health recognition for reducing the risk of tropical infectious diseases via promoting annual meetings where Noul has participated in for several years. Major public health-related national and international organizations, governments, academia, and private sectors have attended the meeting. About Noul Noul is recognized for its innovative technology as the first AI-based diagnostic platform company in the blood and cancer sector, with miLab™ platform introduced as "the most advanced digital microscope and fully integrated bench-top platform" in UNITAID's report in 2022. Website SOURCE Noul

Diagnosis of Plasmodium falciparum malaria using rapid diagnostic tests and treatment with artemisinin derivatives, the main component of the malaria treatments recommended by the World Health Organization (WHO), are under threat in the Horn of Africa. Scientists have detected the emergence and spread in Eritrea of parasites with both artemisinin resistance and genome modifications that prevent their detection with rapid diagnostic tests, thereby jeopardizing malaria control and elimination campaigns in the region and potentially elsewhere in Africa. Diagnosis of Plasmodium falciparum malaria using rapid diagnostic tests and treatment with artemisinin derivatives, the main component of the malaria treatments recommended by the World Health Organization (WHO), are under threat in the Horn of Africa. Scientists from the Laboratory of Parasitology and Medical Mycology at the University of Strasbourg and Strasbourg University Hospital, in collaboration with the Eritrean Ministry of Health, the Institut Pasteur, Columbia University in New York and WHO, have detected the emergence and spread in Eritrea of parasites with both artemisinin resistance and genome modifications that prevent their detection with rapid diagnostic tests, thereby jeopardizing malaria control and elimination campaigns in the region and potentially elsewhere in Africa. The research results were published on September 28, 2023 in the New England Journal of Medicine. Malaria, a disease caused by parasites of the genus Plasmodium, represents a major public health problem worldwide. Plasmodium falciparum, responsible for severe forms, is found mainly in Sub-Saharan Africa, where a child dies of malaria every two minutes. In 2021, 247 million cases and 619,000 deaths were reported, a 6.4% increase compared with 2019. Current strategies to fight malaria involve prevention, with the use of insecticide-treated bed nets; diagnosis, with the introduction of rapid diagnostic tests; and treatment, which must be effective. For more than 15 years, treatment for malaria episodes (which alternate between fever, shivering and chills, and severe sweating) caused by Plasmodium falciparum in Sub-Saharan Africa has been based on artemisinin-based combination therapies (ACTs). These highly effective treatments combine a potent, fast-acting artemisinin derivative and a partner drug with a long half-life that acts more slowly to eliminate residual parasites. Unfortunately, in 2008, the first cases of artemisinin resistance were detected in South-East Asia. Resistance was defined by delayed parasite clearance from the bloodstream of patients treated with an ACT. In recent years, Plasmodium falciparum artemisinin resistance has also been reported in two regions of Sub-Saharan Africa, in Central Africa (Rwanda) and East Africa (Uganda). In this latest study, the scientists present the results of clinical trials conducted between 2016 and 2019 in Eritrea to assess the efficacy of two ACT treatments (artesunate/amodiaquine and artemether/lumefantrine) recommended for treating uncomplicated P. falciparum malaria. The clinical trials also aimed to estimate the proportion of patients with persistent P. falciparum parasitemia on day 3, the day after the last dose of ACT. In addition, the authors sought to identify molecular signatures in the Pfkelch13 gene associated with artemisinin resistance in parasites and to detect deletions of the hrp2 and hrp3 genes which are known to render rapid diagnostic tests ineffective in detecting parasites. The data obtained revealed another hotspot of artemisinin resistance, in Eritrea. This novel area of resistance is more worrying than those observed in Rwanda and Uganda as the investigations reveal the emergence and spread of a new artemisinin-resistant variant, Pfkelch13 622I, accompanied by hrp2 and hrp3 gene deletions in around 17% of cases, making it impossible to detect these parasite strains using rapid tests. According to the published data, it seems that the phenomenon is not recent and that these strains have been circulating in western Eritrea for several years. The findings therefore show how P. falciparum is capable of evading strategies introduced to control and eliminate malaria. "These data are a real cause for concern and undermine the quality of the health management of malaria patients in the region," warns Dr. Selam Mihreteab, a contributor to the study in Eritrea at the National Malaria Control Program, Ministry of Health. "We need to develop constant surveillance of the evolution of these parasites and their ability to spread," adds Dr. Lucien Platon, a PhD student at the Institut Pasteur (Malaria Parasite Biology and Vaccines Unit). "The strategies implemented in the Horn of Africa are under threat, not only because artemisinin resistant parasites are not detected by rapid tests but also because of the ability of malaria vectors to resist insecticides and because we have recently seen the arrival of a new mosquito species, Anopheles stephensi, capable of transmitting these strains in urban environments. There is a risk that these biological threats could lead to a rapid spread of these parasites in the region and beyond," analyzes Professor Didier Ménard, Director of the Institute of Parasitology and Tropical Diseases at the University of Strasbourg and a scientist in the Malaria Parasite Biology and Vaccines Unit at the Institut Pasteur. Over the past two decades, the proactive strategy pursued by the Eritrean government has led to a significant reduction in malaria-related morbidity and mortality in the country. These new data seem to confirm that monitoring the emergence and spread of drug resistance must be a priority in areas such as Eritrea, where strategies to reduce malaria transmission are being effectively implemented, and that there is an urgent need to develop and introduce innovative control strategies. This research received support from the Bill and Melinda Gates Foundation (WHO), the Global Fund (Ministry of Health in Eritrea), the Institut Pasteur, the French Government (National Research Agency), the University of Strasbourg (IdEX Program), and the United States Department of Defense and National Institutes of Health.