PEDS1

Last update 08 May 2025

Basic Info

Synonyms

CarF, Kua, PDES

+ [5]

Introduction

Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane (PubMed:31604315, PubMed:32209662, PubMed:33859415). Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms (PubMed:31604315).

100 Clinical Results associated with PEDS1

100 Translational Medicine associated with PEDS1

0 Patents (Medical) associated with PEDS1

Literatures (Medical) associated with PEDS1

01 Jun 2025·Gene

Molecular cloning, expression, and functional analyses of plasmanylethanolamine desaturase gene of Takifugu rubripes

Article

Author: Yang, Qi ; Zhang, Jing-Jing ; He, Yang-Bin ; Lin, Lei ; Ji, Hong-Long ; Liu, Chang ; Dong, Cai-Chao ; Yang, Yu ; Shao, Chang-Wei

The aging population has led to a significant increase in neurodegenerative diseases, particularly Alzheimer's disease (AD), which adversely affects the quality of life and longevity of the elderly. Abnormal plasmalogen metabolism plays a crucial role in the pathogenesis of AD. This study focused on tmem189, a key gene involved in plasmalogen synthesis. We successfully cloned and characterized the open reading frame (ORF) of tmem189 in Takifugu rubripes, revealing that it encodes a protein consisting of 275 amino acids. Notably, tmem189 expression was found to be higher in brain compared to other tissues. We transfected a GFP-tagged eukaryotic expression vector into 293 T cells, confirming successful expression of tmem189 with increased expression levels. Additionally, liquid chromatography-mass spectrometry (LC-MS) analysis demonstrated that tmem189 promotes plasmalogen synthesis in the transfected 293T cells. Our findings suggest that tmem189 could serve as a potential target for the treatment of neurodegenerative diseases, providing new insights into the promotion of plasmalogen synthesis.

05 Feb 2025·ACS Applied Materials & Interfaces

Green Manufacture of Hydrated Polymers Coatings with On-Demand Mechanics and Lubricity Based on Novel Biobased Polymerizable Deep Eutectic Solvents

Article

Author: Zhang, Jinshuai ; Zhao, Xiaoduo ; Ma, Shuanhong ; Li, Renjie ; Zhou, Feng ; Lv, Siyao ; Sun, Ying

The aging population necessitates a critical need for medical devices, where polymers-based surface lubrication coating is essential for optimal functionality. In fact, lubrication and mechanical requirements vary depending on the service environment of different medical devices. Until now, key mean is still blank for general preparation of hydrophilic polymers-based lubrication coatings with on-demand mechanics and lubricity. This study introduces a novel hydrophilic lubrication coating with tunable mechanical properties and lubricity, derived from eco-friendly polymerizable deep eutectic solvents (PDESs) containing betaine, hydroxyethyl acrylate, glycerol, and tannic acid. Unlike traditional high molecular weight polymers, this approach leverages small-molecule, high-biobased PDESs, thereby simplifying the synthesis process. The resulting coating demonstrates exceptional adhesion to a range of medical device materials─including glass, stainless steel, polyvinyl chloride, and polyurethane─thanks to the high content of hydroxyl groups and pyrogallol motifs from tannic acid. It also enables the precise tuning of mechanical strength, modulus, adhesion, hydrophilicity, and lubrication properties by varying the amounts of glycerol and tannic acid. Furthermore, the coating undergoes a hydration-induced transition from high-strength, high-friction to low-strength, low-friction states, maintaining repeatable performance. Additionally, the synergistic effects of betaine and tannic acid in the PDES contribute to its notable antimicrobial properties. In summary, these PDESs demonstrate significant potential for enhancing lubrication in a range of biomedical devices.

01 Feb 2025·Advanced Science

Porous Deep Eutectic Solvents–Unfulfilled Dream or the Next Breakthrough in Scientific Innovation?

Article

Author: Wysokowski, Marcin ; Sikora, Aleksandra ; Gorczyński, Adam ; Brzęczek‐Szafran, Alina ; Makoś‐Chełstowska, Patrycja ; Jesionowski, Teofil

AbstractPorous deep eutectic solvents (PDES) are capturing the imagination of scientists, promising a revolutionary leap in material science. These innovative materials, blending the versatility of deep eutectic solvents (DES) with the intricate architectures of porous structures, offer an exciting array of applications—from green chemistry and catalysis to energy storage and environmental remediation. However, the journey from laboratory curiosity to industrial application is fraught with challenges. This perspective article analyzes the realm of PDES, scrutinizing the cutting‐edge advancements and the challenges that lie ahead. By exploring their synthesis, unique properties, and diverse application potential, the critical question is asked: are PDES an unfulfilled dream or the next big breakthrough in scientific innovation? A comprehensive analysis reveals a “landscape” ripe with opportunity, suggesting that with targeted research and development, PDES can indeed become a cornerstone technology, driving progress across multiple scientific domains.

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PEDS1

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