KCNE1

Last update 08 May 2025

Basic Info

Synonyms

Delayed rectifier potassium channel subunit IsK, IKs producing slow voltage-gated potassium channel subunit beta Mink, IsK

+ [7]

Introduction

Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:19219384, PubMed:20533308, PubMed:9230439). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:19219384). Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization (PubMed:20533308). The outward current reaches its steady state only after 50 seconds (Probable). Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (PubMed:9230439).

100 Clinical Results associated with KCNE1

100 Translational Medicine associated with KCNE1

0 Patents (Medical) associated with KCNE1

989

Literatures (Medical) associated with KCNE1

01 Jun 2025·Biomedicine & Pharmacotherapy

RvD1 and LXA4 inhibitory effects on cardiac voltage-gated potassium channels

Article

Author: Cruz, Alicia De la ; Benito-Bueno, Angela de ; Zaza, Antonio ; Ronchi, Carlotta ; Socuéllamos, Paula G ; Bartolucci, Chiara ; Valenzuela, Carmen ; Severi, Stefano

The resolution of inflammation is modulated by specialized pro-resolving lipid mediators (SPMs), which can be modified in some cardiovascular diseases. Among these SPMs, RvD1 and LXA₄ prevent atrial fibrillation (AF) remodeling and cardiac hypertrophy, respectively in animal models. However, little is known about their electrophysiological effects on cardiac voltage-gated (VG) ion channels. We used the patch-clamp technique in heterologous systems and cardiomyocytes to assess the acute effects of RvD1, and LXA₄, on VG potassium currents. In silico simulations were used to predict the effect of current modulation on the atrial and ventricular action potentials (AP). RvD1 (5 nM) reduced I_Ks (channel K_V7.1/KCNE1) in COS-7 cells and guinea-pig cardiomyocytes by 50.3 ± 7.3 % and 29.9 ± 5.4 % at + 40 mV, respectively, without modifying its voltage dependence. RvD1 was more potent than LXA₄. In heterologous systems, RvD1 was also tested on I_Kur (channel K_V1.5), I_to (channel K_V4.3/KChIP2), I_Kr (channel K_V11.1), and I_K1 (channel K_ir2.1) with the largest inhibitory effect on I_Ks and I_Kr. In in silico simulations RvD1 prolonged repolarization significantly in both atrial and ventricular myocytes. All these results provide a comprehensive evaluation of RvD1 and LXA₄ on cardiac human potassium channels, at pathophysiologically relevant concentrations, being RvD1 more potent than LXA₄. The predicted effects on the AP suggest that, along with their antiinflammatory action, RvD1 may reverse AF-induced electrical remodeling in the atria by their modulation of K⁺ currents. The same action might instead contribute to ventricular functional remodeling; however, direct evidence for this is missing.

01 Jun 2025·Journal of Equine Veterinary Science

Gene expression patterns of the four cardiac chambers in the Thoroughbred horse

Article

Author: Forbes, Bronte ; Premont, Antoine ; Arevalo-Turrubiarte, Magdalena ; Kemp, Victoria ; Edling, Charlotte E ; Uribe, Marcos Castellanos ; Weir, Joe ; Lewis, Rebecca ; Jeevaratnam, Kamalan ; Marr, Celia

Athlete horses' contraction and conduction of the healthy heart influences racing performance. Gene expression patterns in the horse heart are not yet fully investigated. We aim to evaluate the gene expression of the four chambers of the heart overall and with focus on genes involved in the electrophysiology of the heart in Thoroughbred racehorses with no clinical cardiac abnormalities. Tissue was collected from the left atrium (LA), right atrium (RA), left ventricle (LV), and right ventricle (RV). Total RNA was analysed by microarray technique. We compared gene expression in the heart chambers by contrasting atrial against ventricular chambers (chamber related differences), and by contrasting left side to right side (left-to-right related differences). The pathway analyses revealed that RA was characterised by significantly lower expression of genes related to energy derivation and metabolism in comparison to both ventricles and left atria. LA, on the other hand, was characterised by higher expression of genes related to cardiac conduction, and less expression of cardiac morphogenesis, compared to ventricles. The left-to-right related comparisons indicated wider differences between the atria than between the ventricles. Mapping of the genes specifically involved in cardiac conduction and contraction indicated clear chamber related differences. Some potassium channels, KCNE1 and KCNJ2,3 and 4, showed distinct atrial-ventricular specificity and genes involved in calcium regulation were, as a group, more abundant in both atria compared to ventricles. Our results provide a general overview of the gene expression pattern in the healthy racehorse, with particular focus on the cardiac ion channels.

01 Apr 2025·Journal of Controlled Release

Noninvasive assessment of a bioconductive patch for treating atrial fibrillation with magnetic resonance imaging

Article

Author: Lu, Ting-Hsuan ; Peng, Sheng-Yao ; Wang, Minyao ; Shi, Sophia ; Zhang, Chongyu ; Li, Ren-Ke ; Sung, Hsing-Wen ; Li, Shu-Hong ; Fan, Cheng ; Wu, Jun ; Dychiao, Adrian Tabora ; Song, Siyang ; Chang, Yen

Electrical and structural remodeling disrupt atrial electrical conduction, leading to atrial fibrillation (AF). Epicardially delivered conductive biomaterial patches can effectively transmit electrical signals and potentially diminish AF. However, given the progressive nature of AF development, continuous and noninvasive monitoring is essential for assessing the therapeutic efficacy of these patches over time. In this study, superparamagnetic iron oxide nanoparticles (SPIO NPs) are synthesized and used to label a bio-conductive patch made of poly-3-amino-4-methoxybenzoic acid (PAMB) conjugated to gelatin (PAMBG-NP). Incorporating SPIO NPs does not alter the mechanical, electrical, or biocompatible properties of PAMBG. PAMBG-NP restores conduction velocity, suppresses rotor generation, and prevents re-entry currents, thereby relieving AF burden in an in vitro pacing model. In vivo, a bell-shaped PAMBG-NP patch is applied to the right and left atria of KCNE1 knockout mice. Compared to its Gelatin-NP counterpart, PAMBG-NP significantly reduces AF duration and enhances post-AF recovery over a 60-day period. Furthermore, magnetic resonance imaging indicates that PAMBG-NP degrades more slowly than Gelatin-NP, along with having a reduced incidence of AF in PAMBG-NP-treated animals. Therefore, incorporating SPIO NPs into PAMBG enables real-time, in vivo monitoring, potentially facilitating the noninvasive evaluation of its therapeutic efficacy.

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KCNE1

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