MOS

Last update 08 May 2025

Basic Info

Synonyms

MOS, MOS proto-oncogene, serine/threonine kinase, Oocyte maturation factor mos

+ [3]

Introduction

Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation.

100 Clinical Results associated with MOS

100 Translational Medicine associated with MOS

0 Patents (Medical) associated with MOS

777

Literatures (Medical) associated with MOS

01 May 2025·International Journal of Biological Macromolecules

Molecular modification and preliminary application of a novel mannanase from Alkalihalobacillus hemicellulosilyticus

Article

Author: Huo, Ying ; Zheng, Suiping ; Chen, Suping ; Lin, Ying ; Tang, Shiming

Mannooligosaccharides (MOS) are high-quality prebiotic components, and enzymatic production of MOS is the most efficient, simple, and environmentally friendly method. Mannanase is the key enzyme involved in the decomposition of mannan for MOS production. However, there are currently challenges in obtaining thermally stable Mannanase. In this study, a novel thermo-alkaline mannanase, ManB085, was discovered from Alkalihalobacillus hemicellulosilyticus and heterologously expressed. The optimal temperature and pH of this enzyme are 75 °C and 10, respectively, and it remains stable at pH 7-12 and temperatures below 50 °C. Through rational design, a mutant ManB085M, with the non-catalytic domain truncated, was obtained, showing significantly improved thermal stability. The half-life of the mutant at 75 °C is 12.3 times that of the wild type, and the T₅₀ increased by 23 °C. Notably, the enzyme can also produce MOS by hydrolyzing hemicellulose in coffee grounds. To enhance the MOS production capability, a Carbohydrate-Binding Module (CBM) was added to the C-terminus of ManB085M, significantly improving its ability to extract MOS from coffee grounds. This study proposes a novel mannanase with significant potential in MOS production.

01 Apr 2025·Theriogenology

Editing the growth differentiation factor 9 gene affects porcine oocytes in vitro maturation by inactivating the maturation promoting factor

Article

Author: Bei, Chang ; Jiao, Yafei ; He, Zuyong ; Liu, Xiaohong ; Guo, Jinming ; Cong, Peiqing ; Liao, Alian ; Jiang, Tiantuan ; Mi, Bingqian ; Jiang, Xintong ; Chen, Yaosheng ; Li, Xinran

Growth differentiation factor 9 (GDF9), an oocyte-secreted factor, plays a vital role in porcine oocyte development. However, its function during oocyte in vitro maturation (IVM) remains unclear. In this study, we achieved GDF9 editing in approximately 59 % of cultured oocytes by cytoplasmic injection of a pre-assembled crRNA-tracrRNA-Cas9 ribonucleoprotein complex into porcine oocytes at the germinal vesicle (GV) stage. GDF9 editing caused significant damage to porcine oocytes during IVM. Additionally, GDF9 editing impaired mitochondrial function, increased reactive oxygen species (ROS) accumulation, and decreased glutathione (GSH) levels. The impaired IVM of GDF9-edited porcine oocytes was primarily driven by active cAMP-PKA signaling, which inhibited MOS expression, leading to the activation of the WEE1B/MYT1 kinase and inactivation of CDC25B phosphatase. This cascade resulted in the inactivation of CDK1, thereby preventing the activation of maturation-promoting factor (MPF) and inhibiting first polar body (PB1) extrusion. Our findings enhance the understanding of GDF9's regulatory role in porcine oocyte IVM and provide a theoretical foundation for improving porcine reproductive performance.

01 Feb 2025·Biotechnology Journal

Mitochondrial Oxidative Stress Related Diagnostic Model Accurately Assesses Rheumatoid Arthritis Risk Stratification and Immune Infiltration Characterization

Article

Author: Wang, Dexun ; Li, Qianqian ; Diao, Xiaopeng ; Wang, Qizun

ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that affects synovial joints, leading to joint destruction, impaired physical function, and reduced quality of life. However, no accurate method for assessing RA risk currently exists. Given the critical role of early detection and intervention in RA management, further comprehensive risk assessments are essential. Mitochondrial oxidative stress (MOS) is a key factor in the initiation and progression of RA. The bidirectional interaction between RA and MOS supports the feasibility of MOS‐based risk stratification for RA. Using public databases, we first applied the weighted gene co‐expression network analysis (WGCNA) model to identify key genes involved in RA among MOS‐related genes. Differential expression patterns of MOS‐related genes were then analyzed using various machine learning algorithms to identify potential biomarkers. A nomogram model was established using CDKN1A, GADD45B, and MAFF genes to predict RA risk, followed by an evaluation of its reliability and stability. Additionally, we analyzed MOS‐associated molecular subtypes and immune infiltration characteristics. Our findings highlight the significant role of MOS in RA development and underscore the clinical value of personalized treatment strategies.

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