Last update 23 Jan 2025

PLCγ1

Basic Info

Synonyms
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, NCKAP3, Phosphoinositide phospholipase C-gamma-1
+ [12]
Introduction
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (PubMed:17229814).

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