CTDP1

Last update 08 May 2025

Basic Info

Synonyms

CTD phosphatase subunit 1, CTDP1, FCP1

+ [2]

Introduction

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.

100 Clinical Results associated with CTDP1

100 Translational Medicine associated with CTDP1

0 Patents (Medical) associated with CTDP1

136

Literatures (Medical) associated with CTDP1

30 Aug 2022·mBio

The Plasmodium falciparum Nuclear Protein Phosphatase NIF4 Is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity

Article

Author: Zhu, Liying ; Zhou, Dan ; Qin, Junling ; Wang, Jingjing ; Zhu, Xiaotong ; Chen, Lumeng ; Siddiqui, Faiza Amber ; Li, Siqi ; Cui, Liwang ; He, Lu ; Wang, Chengqi ; Yu, Yuanchao ; Miao, Jun ; Cao, Yaming

Protein phosphorylation regulates a multitude of cellular processes. The eukaryotic FCP1 phosphatase acts as a CTD-phosphatase to critically balance the phosphorylation status of the CTD of the RNAPII, controlling the accurate execution of the transcription process.

12 Aug 2022·Nucleic Acids Research

Editor's Note to ‘Transcription activation by targeted recruitment of the RNA polymerase II CTD phosphatase FCP1’

Communications

Author: Stoddard, Barry L. ; Sale, Julian E.

01 Aug 2022·Journal of Cell Science

A transcriptionally repressed quiescence program is associated with paused RNA polymerase II and is poised for cell cycle re-entry

Article

Author: Gala, Hardik P. ; Dhawan, Jyotsna ; Saha, Debarya ; Purohit, Gunjan ; Aloysius, Ajoy ; Venugopal, Nisha

ABSTRACTAdult stem cells persist in mammalian tissues by entering a state of reversible quiescence, referred to as G0, which is associated with low levels of transcription. Using cultured myoblasts and muscle stem cells, we report that in G0, global RNA content and synthesis are substantially repressed, correlating with decreased RNA polymerase II (RNAPII) expression and activation. Integrating RNAPII occupancy and transcriptome profiling, we identify repressed networks and a role for promoter-proximal RNAPII pausing in G0. Strikingly, RNAPII shows enhanced pausing in G0 on repressed genes encoding regulators of RNA biogenesis (such as Ncl, Rps24, Ctdp1), and release of pausing is associated with increased expression of these genes in G1. Knockdown of these transcripts in proliferating cells leads to induction of G0 markers, confirming the importance of their repression in establishment of G0. A targeted screen of RNAPII regulators revealed that knockdown of Aff4 (a positive regulator of elongation) unexpectedly enhances expression of G0-stalled genes and hastens S phase; however, the negative elongation factor (NELF) complex, a regulator of pausing, appears to be dispensable. We propose that RNAPII pausing contributes to transcriptional control of a subset of G0-repressed genes to maintain quiescence and impacts the timing of the G0-G1 transition.This article has an associated First Person interview with the first authors of the paper.

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CTDP1

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