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Last update 08 May 2025

TMED

Last update 08 May 2025

Basic Info

Synonyms

p24 family, TMED/p24 protein family, transmembrane emp24-like trafficking proteins

Introduction-

Drugs associated with TMED

AGN 192403

Target

I1 receptor x TMED9

Mechanism

I1 receptor modulators [+1]

Active Org.

Allergan plc

Originator Org.

Allergan UC

Active Indication-

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

BRD-4780

Target

TMED9

Mechanism

TMED9 modulators

Active Org.-

Originator Org.

The Broad Institute, Inc.

Active Indication-

Inactive Indication

Medullary Cystic Kidney Disease

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

HG-1243

Target

TMED5

Mechanism

TMED5 modulators

Active Org.-

Originator Org.

Human Genome Sciences, Inc.

Active Indication-

Inactive Indication-

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with TMED

100 Translational Medicine associated with TMED

0 Patents (Medical) associated with TMED

291

Literatures (Medical) associated with TMED

01 May 2025·Brain Research Bulletin

Effects of basal division of posterior pallial amygdala on the motor behaviors in pigeons based on transcriptome analysis

Article

Author: Jiang, Feng ; Yi, Chunzhi ; Tian, Xinmao ; Li, Xiujuan ; Wang, Zishi ; Jia, Chongchong ; Shi, Yuhua ; Wang, Zhenlong

The basal division of posterior pallial amygdala (PoAb) was one important part of the amygdala in birds. PoAb mainly mediated turning behavior. However, the regulating neuromechanisms of PoAb in motor behavior was not clear yet. In this study, we selected septalis lateralis (SL) as the stimulated nucleus because it was closely associated with PoAb and had clear neuroregulatory functions, and we also used unrelated nuclei (entopallium) and unstimulated blank treatment (CK) as controls. We aim to study the neuroregulatory mechanisms of PoAb by investigating the differences of transcriptome level in different groups. A total of 622 differentially expressed genes (DEGs) were obtained from PoAb after comparing the SL stimulating group with the CK control group. GO functional annotation and KEGG pathway enrichment analysis showed that the upregulated 608 DEGs mainly involved energy supply and fluid balance. A total of 345 DEGs were obtained from the PoAb when comparing SL stimulation group and entopallium stimulation group. The upregulated 187 DEGs were mainly involved in cell communication and signal transductions. The study indicated that PoAb may modulate motor behaviour mainly by increasing ATP production and facilitating synaptic transmission, in which genes such as SMAD3, TMED3, GRIA2, HTR1B and SNCG play an important role. We revealed the mechanisms of brain regulation behaviour from gene level, and provided the theoretical foundation for understanding the avian brain.

01 Apr 2025·Journal of Gastroenterology and Hepatology

NOTIFICATION: MiR‐876‐3p Regulates Cisplatin Resistance and Stem Cell‐like Properties of Gastric Cancer Cells by Targeting TMED3

01 Apr 2025·Journal of the American Academy of Dermatology

A genome-wide association meta-analysis links hidradenitis suppurativa to common and rare sequence variants causing disruption of the Notch and Wnt/β-catenin signaling pathways

Article

Author: Saemundsdottir, Jona ; Melsted, Pall ; Hjalgrim, Henrik ; Knowlton, Kirk U ; Riis, Peter Theut ; Kjærsgaard Andersen, Rune ; Stefansdottir, Lilja ; Pedersen, Ole Birger Vesterager ; Nyegaard, Mette ; Hansen, Thomas Folkmann ; Ferkingstad, Egil ; Ostrowski, Sisse Rye ; Thorleifsson, Gudmar ; Zachariae, Claus ; Sørensen, Erik ; Dinh, Khoa Manh ; Jemec, Gregor Borut Ernst ; Banasik, Karina ; Halldorsson, Gisli ; Brunak, Søren ; Bruun, Mie Topholm ; Nadauld, Lincoln D ; Orvar, Kjartar B ; Saunte, Ditte Marie Lindhardt ; Jonsdottir, Ingileif ; Walters, Bragi ; Thomsen, Simon Francis ; Brodersen, Thortsen ; Stefansson, Kari ; Stefansson, Hreinn ; Knight, Stacey ; Oddsson, Asmundur ; Mikkelsen, Chirstina ; Sigurgeirsson, Bárdur ; Holm, Hilma ; Gudbjartsson, Daniel ; Sulem, Patrick ; Norddahl, Gudmundur L ; Ullum, Henrik ; Erikstrup, Christian ; Olafsdottir, Thorunn A ; Eidsmo, Liv ; Rutsdottir, Gudrun

BACKGROUNDThe contributions of genetic and environmental risk factors to hidradenitis suppurativa (HS) are both poorly understood.OBJECTIVETo identify sequence variants that associate with HS and determine the contribution of environmental risk factors and inflammatory diseases to HS pathogenesis.METHODSA genome-wide association meta-analysis of 4814 HS cases (Denmark: 1977; Iceland: 1266; Finland: 800; UK: 569; and US: 202) and 1.2 million controls, searching for sequence variants associated with HS.RESULTSWe found 8 independent sequence variants associating with HS, 6 common and 2 rare (frequency <1%). Four associations point to candidate causal genes, NCSTN, PSENEN, WNT10A, and TMED10, that all map to the Notch and Wnt/β-catenin signaling pathways, involved in epidermal keratinization.LIMITATIONSLimited racial diversity may prevent identification of sequence variants of particular importance in non-Caucasian populations.CONCLUSIONSThese findings demonstrate that genes and pathways involved in epidermal keratinization are the genetic backbone of HS pathology.

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TMED

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