Last update 08 May 2025

PEA15

Basic Info

Synonyms
15 kDa phosphoprotein enriched in astrocytes, Astrocytic phosphoprotein PEA-15, HMAT1
+ [10]
Introduction
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Analysis

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