CDCA3

Last update 08 May 2025

Basic Info

Synonyms

C8, CDCA3, cell division cycle associated 3

+ [6]

Introduction

F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).

100 Clinical Results associated with CDCA3

100 Translational Medicine associated with CDCA3

0 Patents (Medical) associated with CDCA3

1,406

Literatures (Medical) associated with CDCA3

01 Jun 2025·Biochemical and Biophysical Research Communications

Investigating the mechanisms of yinchen in the treatment of immune hemolysis: Quercetin's role in complement inhibition and suppression of IL-6/STAT3 signaling

Article

Author: Li, Haiying ; Hu, Xue ; Lang, Yuxiang ; He, Xueqin ; Peng, Xiaodan ; Zhong, Jintong ; Yang, Jiaojiao ; Zhang, Nannan ; Nian, Qing ; Bai, Le ; Yu, Zebo

Yinchen (YC), the dried aerial parts of the medicinal plant Artemisia capillaris Thunb. (family Asteraceae), is primarily distributed across the Asia-Pacific Region. Although YC exhibits clinically validated efficacy against immune hemolytic disorders, its mechanistic underpinnings remain insufficiently elucidated in pharmacological research. This study investigates the potential targets and mechanisms of YC in treating immune hemolysis based on network pharmacology and bioinformatic analysis. Additionally, it aims to verify quercetin's anti-complement activity and inhibition of IL-6-induced STAT3 activation, a key component of YC, through in vitro experiments, molecular docking and molecular dynamics simulations. 13 active components in YC with 143 putative targets were identified by Network pharmacology. Quercetin, beta-sitosterol, and isorhamnetin were top-ranked by target count. 1231 gene targets related to immune hemolysis, with 60 overlapping targets mapping to both YC and the disease were identified. Quercetin exhibited inhibitory activity against both classical and alternative complement pathways, with IC₅₀ values of 528.3 mg/L and 212.5 mg/L, respectively. Quercetin (80 μM) suppressed IL-6-induced IgG secretion and attenuated STAT3 signaling in murine splenic lymphocytes, as evidenced by decreased levels of STAT3 mRNA expression, STAT3 and phosphorylated STAT3 (p-STAT3) proteins. Molecular docking analysis revealed quercetin's putative binding affinity to key complement system components (C1, C2, C3, C4, C5, C8, C9, Factor B) and IL-6, suggesting a dual mechanism of complement pathway modulation and IL-6/IL-6R interaction blockade. Simulation studies confirmed the stable interaction between C1s, C3, C5 and IL-6 and quercetin. Quercetin, a key component of Yinchen used in treating immune hemolysis, demonstrates anti-complement activity and can inhibit IL-6-induced STAT3 activation in vitro.

01 Jun 2025·Annals of Physical and Rehabilitation Medicine

Ulnar compound muscle action potentials predict hand muscle strength 1 year after cervical spinal cord injury: A retrospective analysis

Article

Author: Fox, Ida K ; Schubert, Martin ; Linde, Lukas D ; Berger, Michael J ; Curt, Armin ; Weidner, Norbert ; Abel, Rainer ; Röhrich, Frank ; Dengler, Jana

BACKGROUNDLower motor neuron (LMN) dysfunction caused by anterior horn cell damage in the ventral gray matter during spinal cord injury (SCI) may impact long-term prognosis.OBJECTIVESTo determine the influence of the 3-month ulnar compound muscle action potentials (CMAP; representative of C8-T1 spinal segmental LMN integrity) on hand muscle strength and function, 12 months following SCI.METHODSWe completed retrospective analyses of the European Multicenter Study about SCI (EMSCI) database. Included participants had traumatic SCI (motor complete or incomplete), initial neurological level of injury C1-C8, and ulnar CMAP from the abductor digiti minimi in at least one limb, 3 months after injury. We trichotomized 3-month ulnar CMAP into absent (CMAP = 0.0 mV), reduced (CMAP <6.0 mV), and normal (CMAP ≥6.0 mV), and constructed logistical regression models to predict 12-month C8 and T1 motor scores, dichotomized into poor (≤3) and functional (>3). We explored relationships between trichotomized 3-month ulnar CMAP and 12-month functional Graded Redefined Assessment of Strength, Sensation and Prehension (GRASSP) and Spinal Cord Independence Measure (SCIM) upper limb sub-scales, using non-parametric statistics.RESULTSData from 318 participants (253 males), 46.8 years old (SD 18.4), resulted in CMAP and corresponding motor scores in 629 limbs. Adjusted logistical regression models were significant for C8 and T1 motor scores, with absent (C8 36.6, 95 % CI 12.9-133; T1 38.7, 95 % CI 11.2-24) and reduced (C8 11.0, 95 % CI 6.7-18.4; T1 7.93, 95 % CI 5.2-12.3) CMAP, predictive of poor 12-month motor scores. 12-month GRASSP (n = 30) and SCIM scores were significantly higher in those with normal 3-month ulnar CMAPs than absent and reduced.CONCLUSIONThere is a 7 to 38-fold higher likelihood that SCI individuals with reduced or absent 3-month ulnar CMAP will demonstrate poor hand motor scores at 12 months. This aligns with significantly worse GRASSP and SCIM functional scores. Our findings justify adding LMN health measures in prognostic modeling after SCI.

01 May 2025·European Journal of Pharmaceutics and Biopharmaceutics

Vaginal formulation development: A strategy based on aptamer-guided liposome for human papillomavirus-induced lesions

Article

Author: Ferreira, Catarina ; Venâncio, Carlos ; Lopes-Nunes, Jéssica ; Paulo, António ; Cruz, Carla ; Rolo, Joana ; Gallardo, Eugénia ; Maocha, Izamara Gomes ; Pinto, Maria de Lurdes ; Félix, Luís ; Medeiros-Fonseca, Beatriz ; Palmeira-de-Oliveira, Ana ; Rosado, Tiago ; Martinez-de-Oliveira, José ; Lopes, Melanie ; Gaspar, Carlos ; Pires, Bruno ; Palmeira-de-Oliveira, Rita ; Oliveira, Paula A ; Rosado, Beatriz ; Cabral Campello, Maria Paula

Human Papillomavirus (HPV) is the main cause of cervical cancer, and formulations have been widely used to treat vaginal lesions caused by HPV. Herein, liposomes with acridine orange derivative C₈ were produced and functionalized with AT11 aptamer. Subsequently, they were incorporated into a formulation, prepared based on the universal placebo formulation, which included Thymus vulgaris (TEO) or Origanum vulgare (OEO) essential oils. The formulation was technologically characterized and permeation of C₈ into vaginal tissue was determined. To assess its biological effect, cell viability and internalization tests were carried out using the MTT assay and confocal microscopy, respectively, and antimicrobial susceptibility was also assessed. The prepared formulations were able to internalize cells and reduce cell viability, especially in cancer cell lines. Additionally, formulations showed promising antibacterial and antifungal effects. The effect of the formulation containing TEO and the C₈ AT11 liposomes was also tested in vivo in HPV16 transgenic and wild type mice. Briefly, the formulation proved to be safe for animals and presented some therapeutic potential, namely through the reduction of ear epithelial cells' proliferation. Overall, results suggest that essential oils can increase the anticancer potential of liposomes with associated C₈ and AT11 promotes their selectivity towards cancer cells.

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CDCA3

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