Sanofi to showcase new data from oncology portfolio spanning marketed products and investigational compounds at ASH 2022
Four Sarclisa
®
(isatuximab) oral presentations and 11 posters featuring cutting-edge investigational and marketed therapies to be presented
December 2
, 2022
. Data featured at the 64
th
American Society of Hematology (ASH) Annual Meeting & Exposition from December 10-13, 2022, reinforce Sanofi’s commitment to transforming care for people living with multiple myeloma (MM) and other difficult-to-treat blood cancers.
Peter C. Adamson
, MD
Global Head of Oncology Development
“
Data
to be
presented at this year’s ASH Meeting
demonstrate
our
commitment to
improving the outcome for patients with cancer
. This includes presentations for
Sarclisa
, an
anti-
CD38
antibody
of choice
for
patients
with multiple myeloma
and
a
cornerstone
of our strategy to
broaden our portfolio
in hematologic malignancies
. W
e are
proud to be advancing
knowledge and
the
treatment of
patients with
multiple myeloma
,
by sharing
emerging data from
our research
efforts
.
”
The first Sarclisa oral presentation will detail results from a subgroup analysis of the Phase 3 IKEMA trial, which in
May 2022
reported
updated median progression-free survival results in combination with carfilzomib and dexamethasone. This new analysis compared patients with early versus late relapse. The second Sarclisa oral presentation highlights updated longer-term efficacy data following subsequent therapy in the pivotal
Phase 3 ICARIA-MM
trial. It is critical to advance scientific understanding of how individuals who relapse early will respond to subsequent lines of therapy because the earlier a person relapses, the more difficult they can be to treat.
Sanofi is also presenting multiple abstracts from its investigational early pipeline of cutting-edge compounds, such as an open-label, first-in-human, dose-escalation study of Natural Killer Cell Engager (NKCE) SAR443579 as a monotherapy for the treatment of relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia or high-risk myelodysplasia. Another abstract will highlight the potential of SAR’514, an anti-B cell Maturation Antigen (BCMA) NKCE, for controlling MM tumors in vivo.
Since 2019, Sanofi’s oncology pipeline has doubled, with a dozen next-generation, potential first- or best-in-class compounds entering clinical trials. Much of this growth is a result of an acceleration of in-house research and development capabilities, as well as building external partnerships, particularly in early portfolio, including for MM and other hematologic malignancies.
A
bstracts
accepted for presentation at ASH include:
Isatuximab
Isatuximab Plus Pomalidomide/Low-Dose Dexamethasone Versus Pomalidomide/Low-Dose Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma (ICARIA-MM): Characterization of Subsequent Antimyeloma Therapies
Oral presentation
Abstract #247
Dec. 10, 2-3:30 p.m. CST
Isatuximab Plus Carfilzomib and Dexamethasone in Patients with Early Versus Late Relapsed Multiple Myeloma: IKEMA Subgroup Analysis
Oral presentation
Abstract #753
Dec. 12, 10:30 a.m.-12 p.m. CST
Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone (Isa-KRd) in Patients with High-Risk Newly Diagnosed Multiple Myeloma: Planned Interim Analysis of the GMMG-Concept Trial
Oral presentation by GMMG
Abstract #759
Dec. 12, 10:30 a.m.-12 p.m. CST
Bone Marrow Immune Signatures in Multiple Myeloma Are Linked to Tumor Heterogeneity and Treatment Outcome
Oral presentation by GMMG
Abstract #860
Dec. 12, 2:45-4:15 p.m. CST
Subcutaneous Isatuximab Administration by an On-Body Delivery System (OBDS) in Combination with Pomalidomide and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma: Phase 1b Expansion Study Results
Poster
Abstract #1923
Dec. 10, 5:30-7:30 p.m. CST
Isatuximab Plus Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma: IKEMA Subgroup Analysis By Number of Prior Lines of Treatment
Poster
Abstract #3176
Dec. 11, 6-8 p.m. CST
Isatuximab in Combination with Lenalidomide and Dexamethasone in Patients with High-Risk Smoldering Multiple Myeloma: Updated Safety Run-in Results from the Randomized Phase 3 ITHACA study
Poster
Abstract #3253
Dec. 11, 6-8 p.m. CST
Isatuximab Plus Pomalidomide and Dexamethasone in Patients with Relapsed and/or Refractory Multiple Myeloma in Real-Life Context in France: IMAGE Subgroup Analysis Based on Prior Lines of Therapy and Refractory Status
Poster
Abstract #4928
Dec. 12, 6-8 p.m. CST
Rasburicase
Fatalities from Tumor Lysis Syndrome (TLS) After Anti-Hyperuricemic Monotherapy – Nationally Representative, Propensity Score Matched, Retrospective Study Comparison of Rasburicase and Allopurinol
Poster
Abstract #3632
Dec. 11, 6-8 p.m. CST
Pipeline and other
MAP4K2 Inhibition Reinforces the Iberdomide Sensitivity in MM Cells by Inducing IKZF1 Degradation Through a CRBN Independent Mechanism (Externally Sponsored Collaboration)
Poster
Abstract #1838
Dec. 10, 5:30-7:30 p.m. CST
Real-World Multiple Myeloma Risk Factors and Outcomes by Race/Ethnicity in the United States
Poster
Abstract #2285
Dec. 10, 5:30-7:30 p.m. CST
High Ex Vivo Response Rates to CD38/CD28xCD3 Trispecific T Cell Engager in Patients Relapsed After Anti-CD38 and Anti-BCMA Targeted Immunotherapies (Externally Sponsored Collaboration)
Poster
Abstract #3157
Dec. 11, 6-8 p.m. CST
Real-World Multiple Myeloma Front-Line Treatment and Outcomes by Transplant in the United States
Poster
Abstract #3198
Dec. 11, 6-8 p.m. CST
An Open-Label, First-in-Human, Dose-Escalation Study of SAR443579 Administered as Single Agent by Intravenous Infusion in Patients with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-Cell Acute Lymphoblastic Leukemia (B-ALL) or High-Risk Myelodysplasia (HR-MDS) (Trial in Progress)
Poster
Abstract #3329
Dec. 11, 6-8 p.m. CST
The Novel Trifunctional Anti-BCMA NK Cell Engager SAR’514 Has Potent in-Vitro and in-Vivo Anti-Myeloma Effect Through Dual NK Cell Engagement
Poster
Abstract #4486
Dec. 12, 6-8 p.m. CST
Pegathor Lymphoma, a Phase 2 Study of SAR444245 as a Monotherapy or in Combination with Pembrolizumab for the Treatment of Adults and Adolescents with Relapsed or Refractory B Cell Lymphoma (Trial in Progress)
Online abstract only
About
Sanofi
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