Synonyms CCN family member 1, CCN1, cellular communication network factor 1 + [10] |
Introduction Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. |
Target |
Mechanism CCN1 stimulators [+3] |
Active Org. Kinnear Pharmaceuticals, LlcStartup |
Originator Org. Kinnear Pharmaceuticals, LlcStartup |
Active Indication |
Inactive Indication- |
Drug Highest PhaseDiscovery |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Target |
Mechanism CCN1 modulators [+1] |
Active Org.- |
Originator Org. |
Active Indication- |
Inactive Indication- |
Drug Highest PhasePending |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date08 Apr 2024 |
Sponsor / Collaborator- |
Start Date15 Nov 2023 |
Sponsor / Collaborator- |
Start Date16 Aug 2022 |
Sponsor / Collaborator |