NCOA6

Last update 08 May 2025

Basic Info

Synonyms

Activating signal cointegrator 2, AIB3, Amplified in breast cancer protein 3

+ [16]

Introduction

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

100 Clinical Results associated with NCOA6

100 Translational Medicine associated with NCOA6

0 Patents (Medical) associated with NCOA6

258

Literatures (Medical) associated with NCOA6

01 Apr 2025·Poultry Science

Genome-wide association analysis identified the involvement of MRPS22 in the regulation of Muscovy duck broodiness

Article

Author: Yu, Shiqi ; Zhang, Cheng ; Wang, Xiao ; Yang, Wanli ; Chen, Xingyong ; Lin, Weihuang ; Yang, Xiaowei ; Guo, Liping ; Yu, Hailiang

Compared to Chinese domesticated duck, Muscovy duck is the only species that retains the broodiness characteristic. Strong broodiness seriously limits its reproductive performance. In order to explore the molecular mechanisms that regulate broody behavior in Muscovy duck, this study used whole genome resequencing (WGRS) to obtain genomic variation sites of Muscovy ducks and conducted association analysis with broody traits. A total of 6,131,623 Single Nucleotide Polymorphisms (SNPs)were obtained from 295 female Muscovy ducks. After genome wide association study (GWAS) with the total broody days, average broody days, broody frequency and the first day of broodiness, 39, 130, 29 and 138 significant SNPs were obtained, respectively. The key genes annotated to these SNPs loci include NCOA6, MRPS22, SCAP, CRY2, CK1δ and EZH1, which could be candidate genes regulating the broodiness of Muscovy ducks. Functional analysis showed that over expression of MRPS22 upregulated the expression of CYP19A1 to promote the synthesis of intracellular estradiol, and downregulated the expression of CYP11A1 and 3β-HSD to inhibit the synthesis of progesterone to regulate broodiness of Muscovy ducks. The genetic polymorphism results showed that MRPS22: g.19000662G>A was significantly associated with average broody days. The average broody days in GA mutant ducks increased by an average of 2.23 days compared to wild GG type, which can be used for molecular marker for broody behavior selection. In conclusion, our study revealed MRPS22 regulated the broody performance by affecting the synthesis of estradiol and progesterone, and g.19000662G>A in MRPS22 was significantly associated with average broody days of Muscovy duck.

01 Mar 2025·Acta Biochimica et Biophysica Sinica

<italic>NCOA6</italic> knockdown enhances RSL3-induced ferroptosis in pancreatic cancer cells and increases the sensitivity to gemcitabine

Article

Author: Peng, Li ; Jia, Yuming ; Deng, Yanli ; Ye, Zeng ; Qin, Yi ; Yang, Wuhan ; Wang, Chao ; Zhang, Zhilei ; Fan, Guixiong ; Xu, Xiaowu ; Wang, Xin

Ferroptosis is a type of programmed death characterized by iron-dependent lipid peroxidation, and targeting ferroptosis has been shown to efficiently kill highly aggressive cancer cells. Previously, we confirmed that nuclear receptors regulate ferroptosis in pancreatic cancer. However, whether nuclear receptor co-activators regulate ferroptosis is unclear. Here, we show that knocking down the nuclear receptor co-activator, NCOA6, enhances the sensitivity of pancreatic cancer cells to ferroptosis. Mechanistically, NCOA6 knockdown promotes the expression of ACSL4 while inhibiting the expression of SCD1, resulting in changes in lipid metabolism, sensitivity to RSL3-induced ferroptosis, and sensitivity to gemcitabine in pancreatic cancer. The relationships between NCOA6 and ACSL4 or SCD1 are further explored in clinical specimens. This study reveals that targeting NCOA6 might alleviate gemcitabine resistance in pancreatic cancer.

01 Feb 2025·American Journal of Botany

Fine‐scale diversity models reveal impacts of invasive Gaillardia pulchella on regenerating vegetation in a sand dune grassland

Article

Author: Bakacsy, László ; Orbán, Zsófia

AbstractPremiseGaillardia pulchella is native to North America but invasive in Central Europe, including Hungary, and can significantly alter vegetation dynamics, thereby affecting biodiversity and community structure. This study explored the fine‐scale effects of G. pulchella invasion on the regeneration of old sandy fields in open dune grasslands in Kiskunság National Park, Hungary, within the Pannonian biogeographic region. The impact of invasion on vegetation association structures was estimated by investigating the early stages of the effects of invasion on plant communities.MethodsDiversity models were used to assess compositional diversity (CD) and the number of realized species combinations (NRC) in invaded versus noninvaded stands. Plexus graphs were used to analyze the spatial relationships between G. pulchella and neighboring species at a fine scale (5 × 15 cm).ResultsInvasion‐free stands had higher species richness and greater structural complexity at fine spatial scales, as indicated by CD and NRC functions. Significantly higher CD values in invasion‐free stands compared to invaded stands emphasize the negative impact of G. pulchella on coexistence among native species. Plexus graphs illustrated both negative and positive associations between G. pulchella and native species, suggesting a nuanced competitive role in invaded stands.ConclusionsGaillardia pulchella invasion, though not strongly characterized, has negatively impacted vegetation structure at fine spatial scales, which may potentially intensify over time. The study underscores the importance of early detection and long‐term monitoring for a comprehensive understanding of invasive processes and their effects on plant communities in sandy habitats.

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NCOA6

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