C4orf3

Last update 08 May 2025

Basic Info

Synonyms

ALN, C4orf3, chromosome 4 open reading frame 3

+ [4]

Introduction

Inhibits the activity of the calcium ATPases ATP2A2/SERCA2 and ATP2A3/SERCA3 by decreasing their apparent affinity for Ca(2+).

100 Clinical Results associated with C4orf3

100 Translational Medicine associated with C4orf3

0 Patents (Medical) associated with C4orf3

Literatures (Medical) associated with C4orf3

01 Apr 2025·Cell Metabolism

Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue

Article

Author: Fujimoto, Masanori ; Verkerke, Anthony R P ; Kajimura, Shingo ; O'Leary, Timothy R ; Shinoda, Kosaku ; Inaba, Kenji ; Xiaohan, Cai ; Griffin, Patrick R ; Li, Mark ; Auger, Christopher ; Oikawa, Satoshi ; Ikeda, Kenji ; Stimson, Roland H ; Caycedo, María Paula Huertas ; Yook, Jin-Seon

Adipose tissue thermogenesis contributes to energy balance via mitochondrial uncoupling protein 1 (UCP1) and UCP1-independent pathways. Among UCP1-independent thermogenic mechanisms, one involves Ca²⁺ cycling via SERCA2b in adipose tissue; however, the underlying molecular basis remains elusive. Here, we report that an endoplasmic reticulum (ER) membrane-anchored peptide, C4orf3 (also known as another regulin [ALN]), uncouples SERCA2b Ca²⁺ transport from its ATP hydrolysis, rendering the SERCA2b-C4orf3 complex exothermic. Loss of C4orf3/ALN improved the energetic efficiency of SERCA2b-dependent Ca²⁺ transport without affecting SERCA2 expression, thereby reducing adipose tissue thermogenesis and increasing the adiposity of mice. Notably, genetic depletion of C4orf3 resulted in compensatory activation of UCP1-dependent thermogenesis following cold challenge. We demonstrated that genetic loss of both C4orf3 and Ucp1 additively impaired cold tolerance in vivo. Together, this study identifies C4orf3 as the molecular resistor to SERCA2b-mediated Ca²⁺ import that plays a key role in UCP1-independent thermogenesis and energy balance.

01 Jan 2025·Clinical Breast Cancer

Development of a Preoperative Prediction Model Based on Spectral CT to Evaluate Axillary Lymph Node With Macrometastases in Clinical T1/2N0 Invasive Breast Cancer

Article

Author: Chen, Lili ; Chen, Suping ; Zeng, Fang ; Li, Jing ; Chen, Yilin ; Xue, Yunjing ; Chen, Lihong ; Cai, Weifeng ; Chen, Cong ; Tang, Xiaoxue ; Yang, Zheting ; Wang, Chuang ; Lin, Lin

OBJECTIVESTo develop a prediction model based on spectral computed tomography (CT) to evaluate axillary lymph node (ALN) with macrometastases in clinical T1/2N0 invasive breast cancer.METHODSA total of 217 clinical T1/2N0 invasive breast cancer patients who underwent spectral CT scans were retrospectively enrolled and categorized into a training cohort (n = 151) and validation cohort (n = 66). These patients were classified into ALN nonmacrometastases (stage pN0 or pN0 [i+] or pN1mi) and ALN macrometastases (stage pN1-3) subgroups. The morphologic criteria and quantitative spectral CT parameters of the most suspicious ALN were measured and compared. Least absolute shrinkage and selection operator (Lasso) was used to screen predictive indicators to build a logistic model. The receiver operating characteristic (ROC) curve and decision curve analysis (DCA) were used to evaluate the models.RESULTSThe combined arterial-venous phase spectral CT model yielded the best diagnostic performance in discrimination of ALN nonmacrometastases and ALN macrometastases with the highest AUC (0.963 in the training cohort and 0.945 in validation cohorts). Among single phase spectral CT models, the venous phase spectral CT model showed the best performance (AUC = 0.960 in the training cohort and 0.940 in validation cohorts). There was no significant difference in AUCs among the 3 models (DeLong test, P > .05 for each comparison).CONCLUSIONA Lasso-logistic model that combined morphologic features and quantitative spectral CT parameters based on contrast-enhanced spectral imaging potentially be used as a noninvasive tool for individual preoperative prediction of ALN status in clinical T1/2N0 invasive breast cancers.

04 Dec 2024·Journal of Physics: Condensed Matter

Heterojunction photoelectric device with fast response speed and low power consumption composed of WSSe and AlN

Article

Author: Li, Enling ; Qin, Ke ; Wang, Hanxiao ; Shen, Yang ; Cui, Zhen ; Yuan, Pei

AbstractThrough the accurate calculation of density functional theory, reveal the excellent photoelectric properties of the AlN/WSSe and WSSe/AlN heterojunction. Especially, the hole mobility of the AlN/WSSe heterojunction is as high as 3919 cm2 Vs−1 in armchair direction, and the hole mobility of the WSSe/AlN heterojunction is as high as 4422 cm2 Vs−1 in the zigzag direction. Interestingly, when two H atoms are adsorbed in the WSSe surface, the Gibbs free energy change are −0.093 eV and −0.984 eV, which tends to zero, which can promote the spontaneous reaction of electrocatalytic water decomposition to produce H2. In addition, the AlN/WSSe heterojunction exhibits significant photoelectric effect photocurrent (1.15 a02/photon) in the armchair direction and the heterojunctions have lower threshold voltage (1.5 V), that indicate the AlN/WSSe and WSSe/AlN heterojunction have great application prospect in manufacturing high-performance optoelectronic devices with fast response and low power consumption.

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C4orf3

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