CLPB

Last update 08 May 2025

Basic Info

Synonyms

ANKCLB, caseinolytic mitochondrial matrix peptidase chaperone subunit B, Caseinolytic peptidase B protein homolog

+ [5]

Introduction

Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842).

100 Clinical Results associated with CLPB

100 Translational Medicine associated with CLPB

0 Patents (Medical) associated with CLPB

664

Literatures (Medical) associated with CLPB

01 May 2025·Biochimica et Biophysica Acta (BBA) - General Subjects

Yeast Hsp78 plays an essential role in adapting to severe ethanol stress via mild ethanol stress pretreatment in mitochondrial protein quality control

Article

Author: Nguyet, Vo Thi Anh ; Ando, Ryoko ; Horie, Fuko ; Sekimoto, Koharu ; Izawa, Shingo

Severe ethanol stress (10 % v/v) causes the denaturation and aggregation of certain mitochondrial proteins, such as aconitase (Aco1), forming the deposits of unfolded mitochondrial proteins (DUMPs) in the budding yeast Saccharomyces cerevisiae. Pre-exposing yeast cells to mild stress often induces adaptation to subsequent severe stress. However, whether pre-exposing yeast cells to mild ethanol stress mitigates mitochondrial protein aggregation remains unclear. Therefore, in this study, we examined the effects of pre-exposing yeast cells to mild ethanol stress on the yeast mitochondrial protein quality control (mtPQC) system under severe ethanol stress. Pretreatment with 6 % (v/v) ethanol significantly mitigated the formation of DUMPs and Aco1 aggregates under subsequent 10 % ethanol stress in wild-type cells but not in hsp78∆ and mdj1∆ cells. Pretreatment with 6 % ethanol increased the protein levels of mtPQC-related factors, Hsp78, Mdj1, and Hsp10; however, hsp78∆ cells showed significantly lower levels of Ssc1 (mtHsp70) and its co-chaperone Mdj1 than wild-type cells. Moreover, intracellular reactive oxygen species levels and the frequency of respiration-deficient mutants under 10 % ethanol stress were reduced after pretreatment with 6 % ethanol in wild-type cells but not in hsp78∆ cells. Overall, this study demonstrated that pre-exposing yeast cells to mild ethanol stress mitigated ethanol-induced mitochondrial damage by activating the mtPQC system, including HSP78 expression, providing novel insights into the effects of ethanol stress on mitochondria and the corresponding responses in yeast.

01 Apr 2025·Journal of Psychiatric Research

Enterobacterial caseinolytic protease B (ClpB) and ClpB antibodies in adolescents with anorexia nervosa

Article

Author: Andreani, Nadia Andrea ; Herpertz-Dahlmann, Beate ; Fetissov, Sergueï O ; Thomas, Benjamin ; Lahaye, Emilie ; Seitz, Jochen ; Baines, John F

Caseinolytic protease B (ClpB) produced by the gut enterobacteria displays anorexigenic effects possibly due to its molecular mimicry with α-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropeptide. ClpB is known to induce α-MSH cross-reactive antibodies previously associated with eating disorders. In the present study we analyzed whether long-term changes of serum ClpB, anti-ClpB antibodies and fecal clpB gene content can be associated with disease progression in anorexia nervosa (AN). For this purpose, female adolescents diagnosed with the restrictive type of AN according to DSM-5 were studied at hospital admission, discharge, and at a 1-year follow up visit, while age-matched healthy female participants served as a control group. We found that ClpB protein was detected at variable levels in sera of all study participants without significant group differences. However, anti-ClpB IgG were low in adolescents with AN at the acute phase of disease and were characterized by increased affinity. Long-term individual dynamics of serum ClpB revealed that its increase after hospital discharge was associated with disease relapse. In healthy adolescents, serum ClpB correlated negatively with BMI-SDS. Fecal clpB DNA levels were low in patients at hospital admission and discharge correlating positively with the abundance of Enterobacteriaceae in gut microbiota. Thus, in healthy adolescents enterobacterial ClpB appears as a physiological microbiota-derived factor associated with lower body weight within the normal range. Low levels of anti-ClpB IgG in adolescents with AN may cause insufficient immune control of ClpB, possibly promoting ClpB anorexigenic effects which can be relevant to the pathophysiology of AN.

01 Mar 2025·Biochemistry and Biophysics Reports

Identification and assessment of hub genes and miRNAs coregulatory associated with immune infiltrations and drug interactions in latent tuberculosis based on MicroarrayData analysis, molecular docking, and dynamic simulation

Article

Author: Ha, Hai-Anh ; Dinh, ThiPhuongHoai ; Utegenova, Aigul ; Dinh, PhongSon ; Tran, ChauMyThanh ; Alamri, Abdulaziz ; Ali, Awais

Tuberculosis (TB) remains a major global health concern, with the transition from latent to active TB still poorly understood. Therefore, enhancing clinical management and prevention strategies for TB is essential. High-throughput sequencing data of genes and miRNAs from individuals at different TB stages were obtained from NCBI. Differential expression analysis was performed using the R package limma, alongside GO and KEGG analyses. The central regulatory network of miRNAs was visualized with Cytoscape, and relevant genes were validated using ROC analysis. The predicted key genes involved in the transition from latent to active TB, including PLEKHG1, CLPB, DOK4, IL1β, and TLR3, are primarily associated with multicellular organism processes, stimulus-response, GPCR ligand binding, and immune functions. Finally, we screened Celastrol and Cefaclor Anhydrous targeting IL1β as potent anti-inflammatory drug to reduce the inflammation due to TB. These findings were further validated with Molecular dynamic simulation MM-GBSA and PCA analysis. Our study advances the understanding of latent tuberculosis and identifies genes and microRNAs as potential biomarkers for diagnosis, monitoring, and treatment, with broader implications for complex disease research.

News (Medical) associated with CLPB

29 Nov 2022

·www.prnewswire.com

TargEDys and SymbioPharm enter an exclusive partnership to launch SymbioLife® Satylia® in Germany

LONGJUMEAU, France, Nov. 29, 2022 /PRNewswire/ -- TargEDys and SymbioPharm signed an exclusive marketing and distribution agreement for the launch of SymbioLife® Satylia® in Germany. The novel dietary supplement based on the next-generation probiotic Hafnia alvei HA4597 will be available from January 2023. SymbioLife® Satylia® is a precision probiotic with a characterized mechanism of action at molecular level: it increases satiety thanks to the protein ClpB produced by Hafnia alvei HA4597. ClpB naturally mimics the human satiety hormone alpha-MSH. The improved feeling of satiety helps with successful weight loss, as confirmed by a clinical study with 230 overweight adults. This natural principle provided by SymbioLife ® Satylia ® is a multi-awarded new, natural, safe and effective weight management solution. Grégory Lambert, CEO of TargEDys: "We are extremely proud and excited about this new collaboration. SymbioPharm is in the top 3 of the German probiotics market and fathered one of the first probiotic pharmaceuticals globally. With the team's knowledge of probiotic Enterobacteria, their strong position with doctors, pharmacies, and synergies with probiotics and diagnostics, they are the perfect partner for this highly scientific product." Juergen Eck, Co-CEO and CTO of SymbioPharm: "We are very excited to partner with TargEDys and work together on a new era of evidence-based probiotics. With the patent-protected probiotic Hafnia alvei HA4597, its biological mechanism of action and outstanding studies, we can offer an effective solution for the growing problems of obesity and metabolic health. As pioneers in microbiome research and medical probiotics, we are proud to now also help shape the introduction of knowledge-based precision probiotics." About SymbioPharm SymbioPharm GmbH is a pioneer in microbiome research and knowledge-based probiotics - since 1954. Its mission is to preserve health and to heal diseases with probiotic bacteria – making use of purely biological effect of natural bacteria. Therefore, it researches the human microbiome and develops innovative microbiological therapy approaches. The company holds a state-of-the-art production facility, and showcases comprehensive expertise from diagnostics – with the Institute for Microecology – to innovative solutions. About TargEDys® TargEDys® is a commercial-stage French biotech specialized in the development of nutraceutical solutions through microbiome interventions. The company is based on 15 years of research on the microbiota conducted within academic laboratories. TargEDys®' portfolio focuses on overweight, undernutrition, and mental health, all based on the concept of PreciBiomic strains backed by a molecular mechanism of action and in vivo studies. Contact: Arnaud Faure & Nina Vinot [email protected] Logo - SOURCE TargEDys

License out/inMicrobial therapy

Analysis

Perform a panoramic analysis of this field.

view full example data

Hiro LS Researcher

The AI Search Engine Built to Accelerate Biopharma Decisions

Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.

Ask any biopharma research question→

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Discover Synapse Data Servers

Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

CLPB

Basic Info

Related

Analysis