NAPA

Last update 08 May 2025

Basic Info

Synonyms

Alpha-soluble NSF attachment protein, N-ethylmaleimide-sensitive factor attachment protein alpha, NAPA

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Introduction

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433).

100 Clinical Results associated with NAPA

100 Translational Medicine associated with NAPA

0 Patents (Medical) associated with NAPA

775

Literatures (Medical) associated with NAPA

01 Oct 2025·Bioelectrochemistry

Interfacial extracellular electron uptake is linked to nitrate respiration in the marine heterotroph, Thalassospira xiamenensis SN3

Article

Author: Rowe, Annette R ; Tonucci, Gabriel P ; Sackett, Joshua D

Thalassospira species are ubiquitous marine bacteria with poorly understood ecology, and some have been implicated in iron corrosion. To better elucidate the mechanisms and ecological implications of extracellular electron transfer (EET) in oxidative processes, we conducted genomic and bioelectrochemical characterization of Thalassospira xiamenensis strain SN3, an obligate heterotroph isolated from coastal marine sediment cathode-oxidizing enrichments. Physiologic and genomic analyses indicate that SN3 lacks the capacity for lithoautotrophic growth and lacks homologs to genes canonically involved in EET. Bioelectrochemical characterization of SN3 cells shows that inward EET requires a terminal electron acceptor (respiration). Deletion of nitrate reductase catalytic subunit napA abolished current consumption and catalytic activity under nitrate-reducing conditions. Media exchange experiments demonstrate that inward EET in SN3 is facilitated by direct contact with the electrode, with a formal midpoint potential of -153 ± 16 mV vs. SHE. Through deletion of the formate dehydrogenase fdhABCD and electrochemical characterization of mutant cells, we show that inward EET is not a function of Fdh enzyme sorption to the electrode, as has been demonstrated for other organisms. This provides further evidence of a cell-mediated and contact-dependent EET mechanism. This work provides a foundation for investigating this metabolically versatile organism's yet uncharacterized mechanism of EET.

01 Aug 2025·Water Research

Genome-resolved metagenomic analysis reveals a novel denitrifier with truncated nitrite reduction pathway from the genus SC-I-84

Article

Author: Lin, Yanting ; Meng, Fangang ; Chen, Qianqian ; Li, Jiapeng ; Zuo, Xiaotian

Understanding the genomic and ecological traits of partial denitrification (PD) bacteria is of high importance for developing wastewater treatment technologies. In this study, a PD-based bioreactor was operated, resulting in a mixed culture dominated by a potentially novel PD functional bacterium (SC-I-84). Progressively increased activity in both nitrate reduction and nitrite production were observed in the SC-I-84 enrichment system, whereas the nitrite reduction activity was always negligible. The phylogenetic analysis indicated that SC-I-84 was closely related to an uncultured beta-proteobacterium (99 %), whereas its denitrification functional genes (napA, napB, narV, and narY) exhibited evidence of co-evolution with chromosomal genes from the genus Cupriavidus, order Burkholderiales. In the genetic sketch of SC-I-84, only nitrate-reduction genes (nar and nap) were identified, whereas nitrite-reduction genes (nir) were absent. Notably, nitrate reduction genes were adjacent to carbon metabolism genes (sucB/C, mdh, idh) and a high abundance of tricarboxylic acid (TCA) cycling genes were found. This can promote the utilization efficiency of electron donors by nitrate reduction genes in SC-I-84, thus enhancing the denitrification activity. Furthermore, SC-I-84 positively cooperated with some bacteria that participate in nitrogen and carbon metabolism and other PD bacteria, but negatively interacted with full-denitrification bacteria. These results indicate that the enrichment of SC-I-84 restricted the growth of full-denitrification bacteria, aiding in the maintenance of a stable PD process. Taken together, the meta-genomic analysis of the novel PD functional bacterium is expected to enhance our understanding of PD processes and aid in the development of PD-based wastewater treatment processes.

01 May 2025·Chemosphere

Anticancer drugs alter active nitrogen-cycling communities with effects on the nitrogen removal efficiency of a continuous-flow aerobic granular sludge system

Article

Author: González-Martínez, Alejandro ; Santo Svierzoski, Nicoly Dal ; Pozo, Clementina ; González-López, Jesús ; Castellano-Hinojosa, Antonio ; Gallardo-Altamirano, Manuel J

There is increasing awareness of the presence of anticancer drugs (ACDs) in wastewater. Nonetheless, how ACDs affect the performance of wastewater treatment systems and their microbial populations remains largely unclear. This study investigated the effects of three common ACDs (cyclophosphamide, tamoxifen, and methotrexate) at varying concentrations on physicochemical parameters and drug removal efficiency in an aerobic granular sludge (AGS) system operated in a continuous-flow reactor. Additionally, it examined the abundance of active microbial communities, including nitrifiers (amoA gene from ammonia-oxidizing bacteria and archaea) and denitrifiers (napA, narG, nirK, nirS, nosZ genes), as well as the biodiversity of active prokaryotic communities. The concentration level of ACDs determines variations in biomass density, granule integrity, and removal efficiencies of organic matter (OM) and total nitrogen. Both medium and high ACD concentrations negatively impact these physicochemical parameters. The findings revealed that AGS functioning within a continuous system could help remove ACDs, but removal efficiencies depended on the specific drug and concentration applied. At medium and high ACD concentrations a marked reduction in the abundance of active bacterial and archaeal communities, including nitrifiers and denitrifiers, was observed, alongside a decline in microbial diversity and a transformation in community composition. Specific bacterial genera, which are crucial for OM degradation, nitrification and denitrification were identified as particularly sensitive to anticancer drugs. Our findings highlight the need for monitoring and managing anticancer drugs in wastewater systems, as they can substantially alter treatment performance, nitrogen-cycling communities, and bacterial community composition.

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