PSPC1

Last update 08 May 2025

Basic Info

Synonyms

FLJ10955, paraspeckle component 1, Paraspeckle protein 1

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Introduction

RNA-binding protein required for the formation of nuclear paraspeckles (PubMed:22416126). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (PubMed:22416126). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

100 Clinical Results associated with PSPC1

100 Translational Medicine associated with PSPC1

0 Patents (Medical) associated with PSPC1

154

Literatures (Medical) associated with PSPC1

01 May 2025·International Journal of Biological Macromolecules

Polysaccharide extracted from peony seed meal preventive effect of on loperamide-induced constipation in rats

Article

Author: Han, Zhonghui ; Lü, Lei ; Li, Mengyi ; Zhang, Yingyu ; Zhao, Xiaolei ; Xing, Hanzhu ; He, Jinxing

In the present study, one polysaccharide (named PSP-1) was purified from peony (Paeonia suffruticosa Andr.) seed meal, and its structural characteristics, as well as preventive constipation activity, were investigated. The weight average molecular weight of PSP-1 was 15.3 kDa and was composed of arabinose, galactose, glucose, xylose, and mannose in the molar ratio of 1:4.8:5.1:0.4:0.2. The primary structure of PSP-1 was elucidated through Fourier-transform infrared spectroscopy (FT-IR) and methylation analysis, revealing its glycosidic linkages and branching pattern. In the loperamide-induced constipated rat, PSP-1 significantly increased fecal parameters and accelerated intestinal transit (69 min reduction). PSP-1 enhanced total short-chain fatty acid (SCFAs) production by 9.1 %, particularly propionic and butyric acids. Furthermore, PSP-1 had a bidirectional effect on gastrointestinal hormones: it increased the serum levels of motilin, gastric inhibitory polypeptide, and substance P by 12.8 %, 13.0 %, and 13.4 %, respectively, while decreasing the levels of secretin and vasoactive intestinal polypeptide by 21.7 % and 17.6 %, respectively. Additionally, 16S rRNA sequencing indicated that PSP-1-mediated gut microbiota rebalances, suppressing pathogens and enriching beneficial genera. These findings suggested that PSP-1, a natural plant extract, maybe a dietary supplement that helps prevent constipation, providing a theoretical reference for its application in functional foods.

01 Mar 2025·Cell Stem Cell

PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1

Article

Author: Xu, Mingjiang ; Hong, Juyeong ; Lee, Ji-Hoon ; Yin, C Cameron ; Hromas, Robert ; Sui, Pinpin ; Hamamoto, Karina ; Li, Ying ; Ye, Fengxi ; Quesada, Andrés E ; Wingate, Noah ; Xu, Kerryn Y ; Wang, Jianlong ; Chen, Jianjun ; You, M James ; Yuan, Yaxia ; Su, Rui ; Noor, Asra ; Zhang, Peng ; Wang, Juan ; Zhou, Hongwei ; Huang, Suming ; Zhou, Daohong ; Yang, Feng-Chun ; Chen, Shi

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy characterized by the blockage of myeloid cell differentiation and uncontrolled proliferation of immature myeloid cells. Here, we show that paraspeckle component 1 (PSPC1) is aberrantly overexpressed and associated with poor survival in AML patients. Using human AML cells and mouse models, we demonstrate that PSPC1 is not required for normal hematopoiesis, but it is critical and essential for AML cells to maintain their leukemic characteristics. PSPC1 loss induces robust differentiation, suppresses proliferation, and abolishes leukemogenesis in diverse AML cells. Mechanistically, PSPC1 exerts a pro-leukemia effect by regulating a unique leukemic transcription program via cooperative chromatin binding with PU.1 and activation of tumor-promoting genes, including NDC1, which is not previously implicated in AML. Our findings uncover a unique and crucial role of PSPC1 dependency in AML and highlight its potential as a promising therapeutic target for AML.

01 Mar 2025·Cell Stem Cell

PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia

Article

Author: Jou, Yuh-Shan ; Yeh, Hsi-Wen ; Lang, Yaw-Dong ; Lee, Hsin-Yi

In a recent publication in Cell Stem Cell, Hong et al.¹ uncovered paraspeckle component 1 (PSPC1) as a determinant of leukemogenic characteristics in acute myeloid leukemia (AML). PSPC1 is not essential for normal hematopoiesis but it is upregulated to interact with PU.1 to promote AML progression and is also emerging as a therapeutic target.

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PSPC1

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