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Last update 23 Jan 2025

MRPS

Last update 23 Jan 2025

Basic Info

Synonyms

28S mitoribosome subunit proteins, Mitochondrial ribosomal S proteins, mt SSU proteins

+ [1]

Introduction-

Drugs associated with MRPS

HG-1283

Target

MRPS24

Mechanism

MRPS24 modulators

Active Org.-

Originator Org.

Human Genome Sciences, Inc.

Active Indication-

Inactive Indication-

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with MRPS

100 Translational Medicine associated with MRPS

0 Patents (Medical) associated with MRPS

494

Literatures (Medical) associated with MRPS

01 Dec 2025·Immunologic Research

Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation

Article

Author: Martínez-Benítez, Braulio ; Fonseca-Camarillo, Gabriela ; Furuzawa-Carballeda, Janette ; Barreto-Zuñiga, Rafel ; Yamamoto-Furusho, Jesus K ; Miguel-Cruz, Erika

The ABCC subfamily contains thirteen members. Nine of these transporters are called multidrug resistance proteins (MRPs). The MRPs have been associated with developing ulcerative colitis (UC). This study aimed to evaluate the ABCC expression in UC patients and its role in a dextran sulfate sodium (DSS)-induced colitis mice model under 5-aminosalicylates or methylprednisolone treatment and compared with control without inflammation. DSS-induced colitis mice were treated with 5-aminosalicylates (50 mg/kg 24 h) or methylprednisolone (2 mg/kg 24 h). Human rectal biopsies were obtained from UC patients. The abcc-relative mRNA levels and protein expression were determined by RT-PCR and immunohistochemistry. abcc4, abcc5, and abcc6 mRNA levels were significantly increased in DSS-induced colitis compared to the other groups. The 5-aminosalicylate treatment dramatically increased the abcc2 and abcc3 mRNA levels vs. control. Methylprednisolone treatment increased abcc1 vs. DSS-induced colitis and colitis treated with 5-aminosalicylate. Immunohistochemical analysis revealed down-regulation of ABCC1/ABCC2/ABCC5/ABCC7 in mice colitis vs. control. Treatment with 5-aminosalicylate restored ABCC5 levels, while methylprednisolone restored ABCC2/ABCC5/ABCC7 in colitis mice at similar control levels. Relative mRNA levels of mrp1-5 were increased in active UC patients vs. control. ABCC2/ABCC4/ABCC7 were conspicuously expressed in the mucosa of 5-aminosalicylate and/or methylprednisolone-treated UC patients, while ABCC2/ABCC4/ABCC5/ABCC7 in submucosa, ABCC1/ABCC5/ABCC7 in muscular, and ABCC1/ABCC4/ABCC5/ABCC7 in serosa were expressed vs. controls. This is the first report about the differential up-regulation of the ABCC subfamily gene and protein expression in DSS-induced colitis under aminosalicylates or methylprednisolone treatment.

01 Mar 2025·Food Chemistry

Influence of processing of seitan, tempeh, and firm regular tofu on protein and lipid oxidation and Maillard reaction products formation

Article

Author: Auñon-Lopez, Arturo ; Klein, Amelie ; Pignitter, Marc ; Hinterreiter-Kern, Elena ; Strauss, Matthias ; Varga, Elisabeth

The impact of production and cooking on protein oxidation, lipid oxidation and Maillard reaction products (MRPs) generation was evaluated for firm regular tofu, tempeh, and seitan, three plant-based alternatives to meat products. Tofu showed higher content of protein-bound carbonyls (25.5 ± 5.4 nmol/mg protein) indicating higher degree of protein oxidation, while seitan exhibited the lowest content of MRPs like N(6)-carboxymethyllysine, as revealed by LC-MS/MS. Through determination of the peroxide value and thiobarbituric acid reactive substances as well as analysis of volatile oxidation compounds by GC-MS, an overall higher lipid oxidation level was found in tofu. Likewise, a mean 92.2 % depletion of naturally occurring antioxidant tocopherol, assessed by HPLC-DAD, was observed in tofu. Furthermore, acrylamide was detected in tofu at 196.0 ± 15.4 μg/kg after frying at 190 °C. This study, therefore, concluded that practices used in tempeh and seitan processing are promising strategies to limit oxidation and Maillard reactions in food.

01 Mar 2025·Food Chemistry

Reducing the bitterness of angiotensin-I-converting enzyme (ACE) inhibitory peptides from soybean protein by NADES-driven Maillard reaction

Article

Author: Cao, Chenchen ; Su, Guowan ; Song, Xueying ; Chang, Shuaiqi ; Xu, Zhenqiu ; Sun, Huaxing ; Zhang, Jianan

Soybean peptide (SP) exhibits significant angiotensin-I-converting enzyme inhibitory (ACEI) activity, however, its strong bitterness restricts its use in food industry. This study aimed to reduce the bitterness of SP by natural deep eutectic solvent (NADES)-driven Maillard reaction (MR). Results showed that both the mixtures of Glucose-NADES and the Glucose-Xylose-NADES formed the hydrogen bonds and shown good thermal stability analyzed by using Fourier transform infrared (FTIR), Differential scanning calorimetry (DSC) and Thermogravimetric analysis (TGA). Compared with Glucose-NADES, Glucose-Xylose-NADES exhibited higher reaction activity, while lower ACEI-activity and higher bitterness were observed in its Maillard reaction products (MRPs). It also indicated that NADES's excellent ability to increase umami free amino acid (FAAs) and reduce bitter FAAs during MR, were key factors in reducing bitterness. Some amino acids (Glu, Asp, Leu and Ala) were considered to have a higher contribution to change the bitterness of MRPs. This study is expected to provide a theoretical basis for preparing functional peptides with high activity and good taste.

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