CALB1

Last update 08 May 2025

Basic Info

Synonyms

CAB27, CALB, CALB1

+ [5]

Introduction

Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

100 Clinical Results associated with CALB1

100 Translational Medicine associated with CALB1

0 Patents (Medical) associated with CALB1

4,455

Literatures (Medical) associated with CALB1

01 Jun 2025·Molecular and Cellular Neuroscience

Olfactory bulb interneurons – The developmental timeline and targeting defined by embryonic neurogenesis

Article

Author: Martin-Lopez, Eduardo ; Greer, Charles A ; Spence, Natalie J ; Brennan, Bowen ; Lefèvre, Marion ; Lange, Nathaniel W ; Han, Kimberly

The generation of mouse olfactory bulb (OB) interneurons (INs) is initiated in the embryo but continues throughout life. It is generally agreed that OB INs generated postnatally affect the connectivity of the OB, depending on the timeline of neurogenesis. Here, we focused on OB INs generated embryonically, which have generally received less attention than those generated in the adult. Birthdates of embryonic INs were differentiated by maternal injections of thymidine analogs and their final destinations and phenotypes in the OB analyzed by immunohistochemistry. We found that the first embryonic INs were generated at embryonic day 10 (E10) and continued through the entire embryonic development. Analysis in adult tissues showed that embryonic INs were retained and were distributed across all layers of the OB. Interestingly, an initial lateral preference in cell density was seen in INs generated during E11-E13. Although INs are broadly distributed in the OB, we found that within the granule cell layer (GCL), OB INs distributed mostly in the superficial GCL. Immunostaining for calbindin, parvalbumin, tyrosine hydroxylase, 5T4 and calretinin were lacking co-expression with thymidine analogs labeled cells, suggesting that maturation of embryonic INs occurred slowly following birth. We studied the embryonic neuroblasts migration and differentiation by labeling IN progenitor cells in the lateral ganglionic eminence using in utero electroporation. We found that IN neuroblasts reached the primordial OB as early as E13 and began to differentiate apical dendrites by E15, which extended into the developing external plexiform layer. We established E16 as the embryonic stage at which the prototypical chain of migrating neuroblasts denoting the embryonic rostral migratory stream (RMS) was visible. Collectively, our data highlight the importance of studying OB INs in isolated time windows to better understand the formation of circuits that define the olfactory system function.

01 Jun 2025·Poultry Science

The characterization of uterine calcium transport and metabolism during eggshell calcification of hens laying high or low breaking strength eggshell

Article

Author: Dai, Dong ; Qi, Guang-Hai ; Wang, Jing ; Wu, Shu-Geng ; Zhang, Hai-Jun ; Yang, Ying-Ying

This study investigated the differences of calcium transport-related proteins and metabolites in the uterus of hens with different breaking strength eggshell during the eggshell calcification. A total of 200 Hy-Line Brown laying hens, aged 75 weeks, were selected and categorized into two groups based on the eggshell breaking strength: a high-strength group (HS, > 42 N) and a low-strength group (LS, < 32 N). Laying hens were sampled at 1 h, 7 h (the initiation stage of eggshell calcification), and 17 h (the growth stage of eggshell calcification) post-oviposition (PO). The LS group showed a decreased thickness, weight and weight ratio of eggshells, accompanied with ultrastructural deterioration and total Ca reduction. The expression levels of ATP2A3, ATP2B2, SLC8A1, and SLC8A3 were significantly increased in the HS at 17 h PO when compared to 1 h and 7 h PO, while no significant changes were observed in the LS. At 7 h PO, the LS group had lower uterine mucosa calcium levels, higher TRPV6 protein expression, and lower CALB1 protein expression. In the HS group, uterine metabolites showed a significant increase in glutathione, citrulline, and proline at 7 h PO, whereas, at 17 h PO, the tricarboxylic acid cycle pathway was significantly enriched. These findings suggest that uterine calcium transport activity is relatively subdued during the initiation stage of eggshell calcification, focusing on redox repair activities to maintain homeostasis for mammillary knobs formation. Subsequently, uterine calcium transport activity becomes highly active during the growth stage of eggshell calcification, primarily supporting rapid calcium transport through enhanced energy metabolism. In aged laying hens, the lower eggshell breaking strength may be attributed to decreased calcium levels during the initiation stage and imbalanced redox during the growth stage, which could affect calcium transport and lead to a weak ultrastructure during the calcification period.

01 May 2025·International Journal of Biological Macromolecules

Vinyl sulfone-amino-alkyl supports: heterofunctional matrixes to prevent enzyme release and stabilize lipases via covalent immobilization

Article

Author: Polizeli, Maria de Lourdes Teixeira de Moraes ; Alcantara, Andres R ; de Andrades, Diandra ; Fernandez-Lafuente, Roberto ; Rocha-Martin, Javier ; Abellanas-Perez, Pedro

New trifunctional supports were prepared (amino-octyl-vinyl sulfone (VS)- and amino-hexyl-VS-agarose) and compared to octyl-VS-agarose. They were utilized to immobilize the lipases A and B from Candida antarctica (CALA and CALB). After incubation to generate some enzyme-support bonds and blocking with different nucleophiles, SDS-PAGE analyses showed that all enzyme molecules become covalently immobilized on the support. In all VS biocatalysts, the blocking reagent presented a great effect in the properties of enzymes. The best blocking agents promoted a significant enzyme stabilization compared to the enzyme stability using the amino-alkyl-agarose supports, higher than that using octyl-VS-agarose supports, although these remained the most stable ones in most cases, as the octyl-biocatalysts were significantly more stable than the enzyme immobilized on amino-alkyl-support. Enzyme activities and specificities could be also greatly tuned by the immobilization in the new trifunctional supports, with enzyme activities in many instances enhancing that of the best non-covalently immobilized enzyme. That way, the results on this paper show that the properties of the enzymes when immobilized on these new trifunctional supports may be significantly tuned by the nature of the acyl chain in the support and the nature of the reagent used to block the reactivity of the remaining VS groups.

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CALB1

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