HEPH

Last update 08 May 2025

Basic Info

Synonyms

CPL, HEPH, hephaestin

+ [1]

Introduction

Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body (PubMed:22961397, PubMed:37277838). By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body (By similarity).

100 Clinical Results associated with HEPH

100 Translational Medicine associated with HEPH

0 Patents (Medical) associated with HEPH

515

Literatures (Medical) associated with HEPH

01 Apr 2025·Poultry Science

Study on yolk iron transportation in chick embryo eggs based on transcriptomics

Article

Author: Cui, Zhaowei ; Wei, Shuaishuai ; Ma, Lulu ; Dong, Shijian ; Li, Shugang ; Huo, Jiaying

Chick embryo eggs have a complete system of iron release, delivery, and uptake and thus provide a useful tool to study the fast transportation and absorption of iron. Based on this, the regulatory genes and pathways of iron transportation and uptake at the four key stages of chick embryo incubation, days 6, 9, 12, and 15 (E6, E9, E12, and E15), were investigated. Throughout these four key stages, the iron content decreased in egg yolk, increased in chick embryos, and first increased and then decreased in the yolk sac membrane (YSM) with the highest value of 110.38 mg/kg at E12. A total of 87,499 expressed genes were detected by transcriptome, where the specifically expressed genes at E6, E9, E12, and E15 were 312, 466, 280, and 185 respectively. Mineral absorption pathways involved in mineral uptake, transportation, utilization, and metabolism were significantly enriched in stages E9 to E15. The expression of divalent metal transporter 1 (DMT1) and ferritin heavy chain 1 (FTH1) related to iron transportation was up-regulated considerably from E9 to E12. Heme oxygenase 1 (HMOX1), FTH1, Solute Carrier Family 40 Member 1 (SLC40A1), and hephaestin (HEPH) mainly responsible for the regulation of iron transportation and uptake were up-regulated from E12 to E15. Therefore, stage E9 to E12 was the crucial period for iron initiation and transportation, and DMT1 and FTH1 played an important role in regulating the initiation of iron transportation at the early stage of incubation.

03 Mar 2025·Angewandte Chemie International Edition

Axially Chiral TADF Imidazolium Salts for Circularly Polarized Light‐Emitting Electrochemical Cells

Article

Author: Feng, Liheng ; Zhang, Ke ; Zhang, Bianxiang ; Li, Meng ; Feng, Chao ; Chen, Chuan‐Feng ; He, Lei

AbstractA pair of axially chiral thermally activated delayed fluorescent (TADF) enantiomers, R‐TCBN‐ImEtPF6 and S‐TCBN‐ImEtPF6, with intrinsic ionic characteristics were efficiently synthesized by introducing imidazolium hexafluorophosphate to chiral TADF unit. The TADF imidazolium salts exhibited a high photoluminescence quantum yield (PLQY) of up to 92 %, a small singlet–triplet energy gap (▵EST) of 0.04 eV, as well as reversible redox properties. Furthermore, the enantiomers showed distinct mirror‐image CD and CPL activities with glum values of −3.7×10−3 and +3.4×10−3. Notably, by doping the axial TADF imidazolium salts into achiral TADF sensitizer, sandwich‐structured light‐emitting electrochemical cells (LECs) without the addition of ionic liquids (ILs) or ionic transition‐metal compounds (iTMCs) were fabricated. When driven at 50 A m−2, the LECs displayed an EQE of up to 5.2 % and strong circularly polarized electroluminescence (CPEL) with gEL values of +3.3×10−3 and −3.0×10−3. This represents the first CP‐LEC based on TADF materials and offers a promising strategy for the development of high‐performance CPEL devices.

12 Feb 2025·Chemistry – A European Journal

New Concept on the Generation and Regulation of Circularly Polarized Luminescence

Article

Author: Zhang, Gong ; Zhang, Wei

AbstractCircularly polarized luminescence (CPL) has attracted tremendous attention because of its significant application prospect across multiple fields of three‐dimensional display, data storage, and information encryption. Chirality and luminescence are two necessary prerequisites for the generation of CPL. However, controlling these two factors simultaneously in a rational manner remains a challenge. Herein, we highlight the recent advances on the rational generation and regulation of CPL through the new concept, named matching rules, mainly including fluorescence‐selective absorption, circularly polarized fluorescence energy transfer, and chiral communication between excited state and ground state. An important commonality among these strategies is that they need a good overlap of the corresponding spectra between the luminescent part (fluorescence, phosphorescence, or CPL) and the chiral part (organic, inorganic, or organic‐inorganic hybrid materials), which can be contactless and separate. Different from most previous studies, no covalent or noncovalent interactions between the two parts are required, which makes them more facile and convenient. Finally, we summarize the main advantages of these strategies and the current challenges. We expect this concept to offer insightful and novel understanding and inspiration on CPL generation and regulation.

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HEPH

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