HEPH

Last update 23 Jan 2025

Basic Info

Synonyms

CPL, HEPH, hephaestin

+ [1]

Introduction

May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.

100 Clinical Results associated with HEPH

100 Translational Medicine associated with HEPH

0 Patents (Medical) associated with HEPH

537

Literatures (Medical) associated with HEPH

17 Jan 2025·Chemistry – An Asian Journal

Tunable Circularly Polarized Luminescence Enabled by Photo‐induced Phase Transition in a Blue‐phase Liquid Crystal with a Wide Room‐temperature Window

Article

Author: Guo, Jinbao ; Meng, Xianyu ; Ren, Tianqi ; Kang, Wenxin

AbstractChiral luminescent liquid crystal (LC) materials with switchable circularly polarized luminescence (CPL) signals have received extensive attention, in which the use of light stimulation to achieve different CPL states is of great significance. However, there are very few reports on the generation and regulation of CPL signals enabled by blue phase LC (BPLC). Herein, achieving CPL signal inversion based on the phase transition induced by light/temperature stimulation in a BPLC system with a wide room‐temperature window is reported. A binaphthalene azo‐based chiral photoswitch (S)‐switch 3 with high helical twisted power (HTP) and large HTP variation is synthesized, and a BP system with a wide room temperature range is further fabricated by doping (S)‐switch 3 and a fluorescence molecule into a bulk LC. By regulating the doping amount of (S)‐switch 3, a phase transition from BP to cholesteric (Ch) phase at room temperature is observed upon 365 nm UV light irradiation or during cooling process, and the polarization inversion of CPL signal is correspondingly found due to the different CPL generation mechanisms of BPLC and CLC. This study provides a new strategy for the flexible regulation of CPL signals in a BPLC system.

31 Dec 2024·Veterinary Quarterly

Evaluation of the clinical usefulness of pancreatic alpha amylase as a novel biomarker in dogs with acute pancreatitis: a pilot study

Article

Author: Kim, Hee-hong ; Kim, Keon ; Park, Sin-Wook ; Lee, Chang-Min ; Joo, Jae-Beom ; Ro, Woong-Bin ; Kim, Ock-Kyu ; Suh, Guk-Hyun

Pancreatic alpha amylase (P-AMY) is used as a biomarker of acute pancreatitis (AP) in human medicine. To our knowledge, there are no studies evaluating the usefulness of P-AMY in dogs with AP. In this study, we evaluated the diagnostic value of P-AMY, currently not verified in veterinary medicine. The AP group (n = 40) consisted of dogs with AP diagnosed using clinical signs and laboratory examinations, including abnormal canine pancreatic lipase (cPL) concentration, and compatible abdominal ultrasound examination at first presentation. Evaluation of the canine AP severity (CAPS) score was performed. The control group (n = 38) was composed of normal dogs without any abnormalities in clinical findings, blood exams or diagnostic imaging. The correlation of P-AMY with cPL was confirmed by Pearson's correlation analysis (r = 0.564, p < .001). The sensitivity and specificity for the most appropriate cut-off values of P-AMY were recorded similar to the values of DGGR. The dogs with AP and CAPS ≥11 had significantly higher serum P-AMY (p = .016) contrary to DGGR lipase and cPL. Furthermore, there was a significant difference in the median P-AMY dependent on the presence of systemic inflammatory response syndrome (p = .001). P-AMY showed similar level of diagnostic accuracy along with sensitivity and specificity compared to DGGR lipase. In addition, P-AMY showed a significant association with CAPS score, contrary to cPL and DGGR lipase. Along with other biomarkers associated with AP, P-AMY has the potential of usefulness as a supportive diagnostic and prognostic biomarker of AP in dogs.

31 Dec 2024·International Journal of Veterinary Science and Medicine

Dual effects of ipecac alkaloids with potent antiviral activity against foot-and-mouth disease virus as replicase inhibitors and direct virucides

Article

Author: Semkum, Ploypailin ; Lekcharoensuk, Porntippa ; Pantanam, Achiraya ; Lueangaramkul, Varanya ; Mana, Natjira ; Phecharat, Nantawan ; Theerawatanasirikul, Sirin

Foot-and-Mouth Disease (FMD) is a contagious, blistering disease caused by the Foot-and-Mouth Disease virus (FMDV), which affects livestock globally. Currently, no commercial antiviral agent is available for effective disease control. This study investigated the antiviral potential of natural-derived alkaloids against FMDV in BHK-21 cells. Twelve alkaloids were assessed for their antiviral activities at various stages of FMDV infection, including pre-viral entry, post-viral entry, and prophylactic assays, as well as attachment and penetration assays by evaluating cytopathic effect reduction and directed-virucidal effects. The results showed that ipecac alkaloids, cephaeline (CPL) and emetine (EMT), exhibited dual effects with robust antiviral efficacy by reducing cytopathic effect and inhibiting FMDV replication in a dose-dependent manner. Evaluation through immunoperoxidase monolayer assay and RT-PCR indicated effectiveness at post-viral entry stage, with sub-micromolar EC₅₀ values for CPL and EMT at 0.05 and 0.24 µM, respectively, and high selective indices. Prophylactic effects prevented infection with EC₅₀ values of 0.23 and 0.64 µM, respectively. Directed-virucidal effects demonstrated significant reduction of extracellular FMDV, with CPL exhibiting a dose-dependent effect. Furthermore, the replicase (3Dpol) inhibition activity was identified using the FMDV minigenome assay, which revealed strong inhibition with IC₅₀ values of 0.15 µM for CPL and 4.20 µM for EMT, consistent with the decreased negative-stranded RNA production. Molecular docking confirmed the interaction of CPL and EMT with residues in the active site of FMDV 3Dpol. In conclusion, CPL and EMT exhibited promising efficacy through their dual effects and provide an alternative approach for controlling FMD in livestock.

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HEPH

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