SIM2

Last update 08 May 2025

Basic Info

Synonyms

bHLHe15, Class E basic helix-loop-helix protein 15, MGC119447

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Introduction

Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.

100 Clinical Results associated with SIM2

100 Translational Medicine associated with SIM2

0 Patents (Medical) associated with SIM2

502

Literatures (Medical) associated with SIM2

28 Mar 2025·Current Reviews in Clinical and Experimental Pharmacology

Genetic Determinants of Statin-induced Myopathy: A Network Metaanalysis of Observational Studies

Article

Author: Sivaramakrishnan, Gowri ; Sridharan, Kannan

Introduction:Statin-induced myopathy (SIM) is a prevalent adverse event impacting treatment adherence. Despite extensive exploration of genotypes, conflicting evidence obscures their role in SIM incidence, prompting this network meta-analysis.Methods:Observational studies meeting eligibility criteria (patients on any statin with reported SNPs and SIM details) were systematically reviewed. Severe SIM was defined as creatine kinase elevations exceeding 10 times the upper limit of normal. Mixed treatment comparison pooled estimates were generated from direct and indirect pooled estimates, represented by odds ratios (OR) with 95% confidence intervals (CI), and validated via bootstrap analysis.Results:Thirty-four studies (26,152 participants) examining genotypes spanning drug transporters, metabolizing enzymes, reactive oxygen species production, and myopathy-related genes were analyzed. Significant associations were observed with drug transporters (OR: 1.4; 95% CI: 1.04, 1.5). Notably, solute carrier organic anion transporter 1B1 (SLCO1B1) (rs4149056) exhibited a moderate association with SIM (OR: 2.1; 95% CI: 1.7, 2.6), validated by bootstrap analysis (OR: 2.1; 95% CI: 1.7, 2.8). Similar associations were found for severe SIM with SLCO1B1 (rs4149056) (OR: 3.8; 95% CI: 1.4, 10.4) and ATP Binding Cassette Subfamily B Member 1 (ABCB1) (rs2373588) (OR: 2.8; 95% CI: 1.4, 5.4). Intraclass differences in genetic predictor risks were noted among statins.Conclusion:Our meta-analysis underscores the significant association of SLCO1B1 with SIM, supporting its clinical utility. Further research is warranted to clarify additional genetic predictors. These findings endorse current guidelines advocating for SLCO1B1 genotyping in statin therapy decisions.

01 Mar 2025·The FEBS Journal

Glycaemic sugar metabolism and the gut microbiota: past, present and future

Review

Author: Attaye, Ilias ; Westerbeke, Florine H. M. ; Rios‐Morales, Melany ; Nieuwdorp, Max

Non‐communicable diseases (NCDs), such as type 2 diabetes (T2D) and metabolic dysfunction‐associated fatty liver disease, have reached epidemic proportions worldwide. The global increase in dietary sugar consumption, which is largely attributed to the production and widespread use of cheap alternatives such as high‐fructose corn syrup, is a major driving factor of NCDs. Therefore, a comprehensive understanding of sugar metabolism and its impact on host health is imperative to rise to the challenge of reducing NCDs. Notably, fructose appears to exert more pronounced deleterious effects than glucose, as hepatic fructose metabolism induces de novo lipogenesis and insulin resistance through distinct mechanisms. Furthermore, recent studies have demonstrated an intricate relationship between sugar metabolism and the small intestinal microbiota (SIM). In contrast to the beneficial role of colonic microbiota in complex carbohydrate metabolism, sugar metabolism by the SIM appears to be less beneficial to the host as it can generate toxic metabolites. These fermentation products can serve as a substrate for fatty acid synthesis, imposing negative health effects on the host. Nevertheless, due to the challenging accessibility of the small intestine, our knowledge of the SIM and its involvement in sugar metabolism remains limited. This review presents an overview of the current knowledge in this field along with implications for future research, ultimately offering potential therapeutic avenues for addressing NCDs.

01 Mar 2025·Biochemical and Biophysical Research Communications

Correlation-based nanometric localization using lattice SIM2 and dSTORM in PML nuclear bodies validated by calibration spheres

Article

Author: Place, Christophe ; Catal, Pelin ; Rousset, Corentin ; Juillard, Franceline ; Monier, Karine ; Favier, Arnaud ; Chatre, Elodie ; Lomonte, Patrick ; Neplaz, Rémi

We evaluated the Lattice di-SIM 3D structural illumination method with a focus on Promyelocytic Leukemia Nuclear Bodies (PML NBs). Lattice SIM²'s performance was compared to its predecessor using biological samples and calibration beads. Optimized SIM² parameters revealed PML NBs with a distinct ring-like morphology. Furthermore, we compared Lattice-SIM² with dSTORM, finding a strong correlation between blinking events and the SIM² mask. For 2D nanoscopic correlation, we used the long-lived imaging buffer Eternity, while the modified variant, Eternity-SIM, with a higher refractive index, provided improved 3D correlation for SIM² imaging.

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SIM2

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