HMGCL

Last update 08 May 2025

Basic Info

Synonyms

3-hydroxy-3-methylglutarate-CoA lyase, 3-hydroxy-3-methylglutaryl-CoA lyase, HL

+ [3]

Introduction

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

100 Clinical Results associated with HMGCL

100 Translational Medicine associated with HMGCL

0 Patents (Medical) associated with HMGCL

266

Literatures (Medical) associated with HMGCL

01 Apr 2025·European Journal of Nutrition

Metabolic profile of procyanidin A2 by human intestinal microbiota and their antioxidant and hypolipidemic potential in HepG2 cells

Article

Author: He, Liangqian ; Li, Tongyun ; Li, Wu ; Yang, Ruili ; Yang, Guangmei

PURPOSEProcyanidins have strong potential for antioxidation and decreasing hepatic fat accumulation thus preventing non-alcoholic fatty liver disease (NAFLD). Procyanidin A2 (PCA2), predominately found in cranberries, avocado, peanut red skins and litchi fruit pericarp, is poorly absorbed in the gastrointestinal tract. However, literatures about its metabolic profile by gut microbiota and effects on lipid metabolism are limited. Therefore, the metabolites of PCA2 by human intestinal microbiota as well as their antioxidant and hypolipidemic potential were investigated.METHODSPCA2 was incubated with human intestinal microbiota and the metabolites produced were characterized by UPLC-Q-TOF-MS. The antioxidant and hypolipidemic potential of PCA2 and its microbial metabolites (MPCA2) were evaluated and compared.RESULTSThe metabolism of PCA2 resulted in the formation of 14 metabolites, and the highest antioxidant capacity values were reached after 6 h incubation. In addition, PCA2 and MPCA2 were effective in reducing oxidative stress and lipid accumulation induced by oleic acid (OA) in HepG2 cells. They significantly promoted the phosphorylation of AMP-activated protein kinase (AMPK) and thus stimulated hepatic lipolysis by up-regulating of the expression of carnitine palmitoyl transferase I (CPT-I) and suppressed hepatic lipogenesis by down-regulation of the expression of 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG-CoA) reductase, fatty acid synthase (FAS) and sterol regulatory element binding proteins 1c (SREBP-1c).CONCLUSIONOur results indicated that PCA2 and MPCA2 were effective to prevent OA-induced lipid accumulation and oxidative stress in HepG2 cells, implying that microbial metabolites may play a crucial role in the realization of human health effects of PCA2.

01 Apr 2025·Food Research International

Integrating transcriptomics and Microbiomics to unravel the regulatory effects of Anji white tea on lipid metabolism in HFD-induced obese mice

Article

Author: Zhang, Yifang ; Zhao, Jin ; Qi, Shangxiong ; Li, Xiaojun ; Shi, Xiaolei ; Wang, Zhenyu ; Hu, Chunli

Obesity has become a significant global health concern. Green tea is widely consumed as an internationally popular beverage and it is recognized that various green teas have unique biological activities. Here, the effects of Anji white tea (a green tea) ‌on lipid metabolism in high-fat-diet (HFD)-fed mice were investigated based on multi-omics. The results showed the functional components and antioxidant activity changed significantly in the whole process (fresh leaves-withering-stripping-drying). Oral gavage of Anji white tea water extract (AJT) for 9 weeks significantly lowered body weight, improved dysglycemia, and alleviated liver oxidative injury. Liver transcriptome analysis revealed that AJT regulated the gene expression related to the "valine, leucine, and isoleucine degradation" pathway, including HADH, HMGCL, ACSF3, ACADS, ALDH3A2, and ACAA2. This result was further validated by qPCR and Western blotting. 16S rRNA sequence analysis showed that AJT improved HFD-induced gut dysbiosis by significantly increasing beneficial genera (e.g., Muribaculaceae_norank and Alloprevotella) and reducing harmful bacteria (e.g., Bacteroides, Lachnospiraceae_uncultured, and Helicobacter). Furthermore, correlation analysis found that AJT-induced alteration of genera was greatly associated with obesity-related parameters and genes involved in the "valine, leucine, and isoleucine degradation" pathway. Collectively, our findings indicated that AJT may alleviate obesity by modulating gut microbiota and the "amino acids, valine, and leucine metabolism" pathway.

01 Mar 2025·International Journal of Biological Macromolecules

Corrigendum to “Circular RNA mapping reveals CircCWC22 as a MiR-3059-x sponge in yak fat deposition by regulating HMGCL” [Int. J. Biol. Macromol. Volume. 257, Pt 1 (2024): 128531.]

Author: Shu, Shi ; Yue, Binglin ; Fu, Changqi ; Peng, Wei ; Zhong, Jincheng ; Wang, Hui ; Wang, Haibo ; Qin, Chunyu

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HMGCL

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