PTGR2

Last update 08 May 2025

Basic Info

Synonyms

15-oxoprostaglandin 13-reductase, FLJ39091, PRG-2

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Introduction

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).

100 Clinical Results associated with PTGR2

100 Translational Medicine associated with PTGR2

0 Patents (Medical) associated with PTGR2

Literatures (Medical) associated with PTGR2

01 Jan 2024·American Journal of Surgical Pathology

Targeted RNA Sequencing Highlights a Diverse Genomic and Morphologic Landscape in Low-grade Endometrial Stromal Sarcoma, Including Novel Fusion Genes

Article

Author: Shaw, Patricia ; Kolin, David L. ; Cin, Paola Dal ; Swanson, David ; Nucci, Marisa R. ; Corbett-Burns, Sophie ; Lee, Cheng-Han ; Dickson, Brendan C. ; Chang, Martin C. ; Rouzbahman, Marjan ; Song, Sharon J. ; Demicco, Elizabeth ; Clarke, Blaise ; Cesari, Matthew ; Dube, Valerie ; Turashvili, Gulisa

Low-grade endometrial stromal sarcoma (LGESS) represents a morphologically and genetically heterogenous mesenchymal neoplasm. Previous work has shown that approximately half of LGESS are characterized byJAZF1::SUZ12gene fusions, while a smaller proportion involves rearrangement of other genes. However, a subset of cases has no known genetic abnormalities. To better characterize the genomic landscape of LGESS, we interrogated a cohort with targeted RNA sequencing (RNA-Seq). Cases previously diagnosed as low-grade endometrial stromal neoplasia (n=51) were identified and re-reviewed for morphology and subjected to RNA-Seq, of which 47 were successfully sequenced. The median patient age was 49 years (range: 19 to 85). The most commonly detected fusions wereJAZF1::SUZ12(n=26, 55%) andBRD8::PHF1(n=3, 6%). In addition to the usual/typical LGESS morphology, someJAZF1::SUZ12fusion tumors showed other morphologies, including fibrous, smooth muscle, sex-cord differentiation, and myxoid change. Novel translocations were identified in 2 cases:MEAF6::PTGR2andHCFC1::PHF1. Ten tumors (21%) had no identifiable fusion, despite a similar morphology and immunophenotype to fusion-positive cases. This suggests that a subset of cases may be attributable to fusion products among genes that are not covered by the assay, or perhaps altogether different molecular mechanisms. In all, these findings confirm that RNA-Seq is a potentially useful ancillary test in the diagnosis of endometrial stromal neoplasms and highlight their diverse morphology.

01 Nov 2023·Chemistry & Biodiversity

Molecular Docking and Dynamics Simulations of Ammi visnaga L. Constituents as Antimelanogenic, Anti‐Inflammatory and Anticoagulant Agents

Article

Author: Karacan, Nurcan ; Çatıkkaş, Berna

AbstractIn this study, anti‐melanogenic, anti‐inflammatory and anti‐coagulant potentials of eighteen selected constituents of Ammi visnaga L. were investigated by Induced Fit Docking (IFD) and molecular dynamic simulation with Schrödinger software. The binding free energies of the selected natural compounds were computed by means of ΔG MM‐GBSA studies. Anti‐melanogetic activity of the constituent against agaricus bisporus tyrosinase, Priestia megaterium tyrosinase and Homo sapiens tyrosinase were evaluated. The result showed that apiumetin had more negative binding free energy against three tyrosinase enzymes than cognate ligands, tropolone and kojic acid. Docking analysis was also performed to predict the constituents with anti‐inflammatory activity against human Tumor necrosis factor, Cyclooxygenase‐2, Prostaglandin D2 11‐ketoreductase AKR1C3 and Prostaglandin reductase PTGR2. The results showed that pyranocoumarins (visnadin, dihydrosamidin, samidin) have more negative binding free energy against Cyclooxygenase‐2 and Prostaglandin D2 11‐ketoreductase receptors than cognate drugs, rofecoxib and indomethacin. In addition, docking analysis shows that pyranocoumarins, apiumetin and cimifugin have more negative binding free energy against Vitamin K epoxide reductase than S‐warfarin drug, predicting that they have anticoagulant activity. Furthermore, the constituents and their cognate drugs were subjected to 100 ns MD Simulation to predict their stability at the active sites of the enzymes.

01 Feb 2022·Pediatric Allergy and ImmunologyQ1 · MEDICINE

Host‐microbial interactions between PTGR2 and Bifidobacterium in the early life gut of atopic dermatitis children

Q1 · MEDICINE

Article

Author: Kim, Shin Ah ; Lee, Seung‐Hwa ; Park, Min Jee ; Jung, Sungsu ; Hwang, Sun‐Goo ; Song, Kun Baek ; Hong, Soo‐Jong ; Lee, So‐Yeon ; Kim, Bong‐Soo ; Kang, Mi‐Jin ; Kim, Jeong‐Hyun ; Park, Yoon Mee ; Choi, Eom Ji

AbstractBackgroundGut microbiota dysbiosis is linked to the development and responses of the immune system and can play an important role in the onset of allergic diseases including atopic dermatitis (AD). This study investigated the association between host genetics and the gut microbiota in AD.MethodsA global gene expression profiling of the gut epithelial colonocytes, genetic variations analysis, and the gut microbial composition analysis were performed.ResultsThis study identified the upregulation of PTGR2 (p = .028), a gene involved in prostaglandin catalysis and inflammatory responses, as a potential risk factor for AD. In subsequent fine mapping analysis using 17 single nucleotide polymorphisms (SNPs) of PTGR2 in 864 Korean subjects (420 AD patients and 444 unaffected controls), several SNPs and haplotypes showed significant associations with AD and its SCORing AD (SCORAD) values (p = .002). To investigate host‐microbial interactions, further gut microbiota data and genotypes were obtained from an independent cohort of 176 subjects (91 AD patients and 85 controls). From correlation analysis, a significantly negative association between SNP and Bifidobacterium abundance was observed in AD patients (p = .005). In additional observations of PTGR2‐associated downstream molecules, NRF2 (p = .004) and several antioxidant genes (GSTT1, GCLC, GPX1; p < .05) showed significantly reduced expression in AD patients.ConclusionsOur current findings suggest that the interaction between PTGR2 dysregulated expression and a Bifidobacterium abundance affects a higher risk of AD and a more severe onset.

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PTGR2

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