SPICE1

Last update 08 May 2025

Basic Info

Synonyms

CCDC52, Coiled-coil domain-containing protein 52, SPICE

+ [4]

Introduction

Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.

100 Clinical Results associated with SPICE1

100 Translational Medicine associated with SPICE1

0 Patents (Medical) associated with SPICE1

Literatures (Medical) associated with SPICE1

01 May 2025·Carbohydrate Research

pH-responsive paclitaxel prodrug encapsulated in a polypeptide-chitosan polymer delivery system for osteosarcoma treatment

Article

Author: Wang, Bing ; Lin, Yunfei

Osteosarcoma, a highly invasive and metastatic primary bone malignancy, remains a significant clinical challenge due to the limited improvement in overall survival despite advances in treatment strategies. This highlights the urgent need for the development of more effective therapeutic options. In response, we have developed a novel paclitaxel (PTX)-loaded nanodrug system, PLGA-CS-1@PTX, by incorporating a synthesized epoxy-tetrapeptide derivative (compound 1) with poly(lactic-co-glycolic acid) (PLGA) and chitosan (CS), forming the PLGA-CS-1 composite system. The system was thoroughly characterized for its physicochemical properties, including morphology, particle size, and in vitro release behavior. Scanning electron microscopy (SEM) confirmed the nanostructure of the particles, with particle sizes around 170 nm and a narrow PDI (<0.15), indicating a uniform distribution. In vitro release studies showed a pH-responsive release profile, with 84.8 % of PTX released at pH 5.4 after 65 h of incubation, compared to 68.1 % at pH 6.4 and 14.8 % at pH 7.4, demonstrating good drug release control in acidic environments. Biological assays demonstrated significant inhibition of osteosarcoma cell proliferation in both HOS and U2OS cell lines, with a dose-dependent reduction in SPICE1 expression, suggesting that PLGA-CS-1@PTX can effectively suppress the proliferative activity of osteosarcoma cells by modulating SPICE1 levels. The hydrophobic segment of the peptide enhanced the drug loading capacity and minimized side effects, improving the overall safety profile of the system. This composite system effectively integrates the strengths of each component, offering a promising, safe, and efficient strategy for osteosarcoma treatment with great potential for clinical application.

01 May 2025·Biochemical and Biophysical Research Communications

Bioinformatics analysis reveals the diagnostic and therapeutic value of the centrosome replication-related gene SPICE1 in keloid

Article

Author: Xia, Zhengguo ; Wang, Fan ; Hu, Chao ; Wang, Wengting ; Li, Xiaojing ; Wang, Jun ; Zhang, Jingsong ; Wang, Yin

Keloids are the abnormal accumulation of collagen in the dermis, which leads to the formation of raised fibrous tissue at the site of injury and the development of a hard scar. The underlying pathological mechanisms associated with keloids have not been fully elucidated. In this study, two GEO datasets (GSE44270 and GSE7890) were employed alongside two machine learning algorithms, Support Vector Machine-Recursive Feature Elimination (SVM-RFE) and Random Forest, to identify diagnostic biomarkers associated with centrosome replication. Following identifying these biomarkers, researchers conducted a functional enrichment analysis to elucidate their biological significance and constructed a gene regulatory network to map their interactions. Furthermore, the study investigated the role of SPICE1 in keloid formation, utilizing a mouse model to explore its potential implications in this pathological process. Researchers identified ten diagnostic markers associated with centrosome replication, among which SPICE1 was significantly upregulated in keloid tissues and fibroblasts. In vivo experiments further demonstrated that the overexpression of SPICE1 promotes keloid formation. Additionally, functional enrichment analysis revealed a connection between these markers and immune cells, suggesting that the immune system may play a crucial role in the development of keloids. This study indicates that SPICE1 is a potential diagnostic marker and therapeutic target for keloids. It offers new insights into the pathological mechanisms of keloids and the development of novel treatments.

01 Jul 2023·Journal of the Mechanical Behavior of Biomedical Materials

Biochemical mechanism involved in the enhancement of the Young's modulus of silk by the SpiCE protein

Article

Author: Kim, Yoonjung ; Park, Wooboum ; Na, Sungsoo ; Yoon, Taeyoung ; Shin, Hongchul

Silk fibers are known for their superior mechanical properties, with the strongest possessing over seven times the toughness of kevlar. Recently, low molecular weight non-spidroin protein, spider-silk constituting element (SpiCE), has been reported to enhance the mechanical properties of silk; however, its specific action mechanism has not yet been elucidated. Here, we explored the mechanism by which SpiCE strengthened the mechanical properties of major ampullate spidroin 2 (MaSp2) silk through hydrogen bonds and salt bridges of the silk structure via all-atom molecular dynamics simulations. Tensile pulling simulation on silk fiber with SpiCE protein revealed that the SpiCE protein enhanced the Young's modulus by up to 40% more than that of the wild type. Bond characteristic analysis revealed that SpiCE and MaSp2 formed more hydrogen bonds and salt bridges than the MaSp2 wild-type model. Sequence analysis of MaSp2 silk fiber and SpiCE protein revealed that SpiCE protein contained more amino acids that could act as hydrogen bond acceptors/donors and salt bridge partners. Our results provide insights into the mechanism by which non-spidroin proteins strengthen the properties of silk fibers and lay the groundwork for the development of material selection criteria for the design of de novo artificial silk fibers.

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