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Dublin, June 29, 2023 /PRNewswire/ -- The "Extracellular Vesicles 2023: Drug Delivery, Biologics & Therapeutics" conference has been added to ResearchAndMarkets.com's offering. Welcome to the Extracellular Vesicles 2023 Conference: From Technologies to Biomarker Cargo to Diagnostics. This conference is being held July 26-27, 2023 in Orlando, Florida close to the Walt Disney World Resort and Attractions. The host is honored to welcome Professor Mei He, University of Florida as Conference Chairperson. This conference brings together academic and industry participants for a 2-day deep dive into timely topics in the Extracellular Vesicles (EVs) field with emphasis on technologies for the isolation and study of extracellular vesicles as well as the downstream studies in the EV field such as therapeutics development. In addition to the biomarker and diagnostic potential of EVs, we explore at this conference the latest work and developments in EV-based Therapeutics and the Drug Delivery and Therapeutics Opportunities in the EV Field. Presentations at this conference from academics as well as industry participants and the goal is 2 days of scientific exchange as well as networking opportunities. We welcome exhibitors and companies in the field to engage and participate at this conference and showcase their latest developments and offerings to the field. **This is a 2-Track Conference with Attendees Accessing All 2-Tracks** One Track Focuses on EV Technologies, Biomarkers & Diagnostics The Other Track Focuses on EV-based Drug Delivery, Biologics, and Therapeutics Development Agenda Topics Animal Models for Studying Extracellular Vesicles for Therapeutics, Drug Delivery Expression and Deployment of Biologics from Extracellular Vesicles (EV) for Therapeutics Applications Extracellular Vesicles (EVs): Therapeutic and Drug Delivery Potential GMP Requirements in EV Scale-Up and Production Technologies for Engineering EVs for Therapeutics, Drug Delivery Vehicles Agenda: Wednesday, 26 July 2023 08:00 - Conference Registration and Materials Pick-Up + Coffee Session Title: Where Does the Field of EVs Stand, circa 2023? 09:00 - Mei He - Conference Chair Welcome and Introduction by Conference Co-Chairperson Mei He, Assistant Professor, University of Florida, United States of America 09:05 - Michael Graner - Conference Chair Welcome and Introduction by Conference Co-Chairperson Michael Graner, Professor, Dept of Neurosurgery, University of Colorado Anschutz School of Medicine, United States of America 09:15 - Lucia Languino - Keynote Presentation Extracellular Vesicle Integrins: Novel Opportunities for the Diagnosis and Therapy of Cancer Lucia Languino, Professor of Cancer Biology, Thomas Jefferson University, United States of America 09:45 - Dominique PV de Kleijn - Keynote Presentation Plasma Extracellular Vesicles for Cardiovascular Disease Dominique PV de Kleijn, Professor Experimental Vascular Surgery, Professor Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands, Netherlands 10:15 - Kristin Kopperud - Keynote Presentation Low Earth Orbit Research Opportunities on the International Space Station Kristin Kopperud, Program Director, Biomedicine, International Space Station National Laboratory, United States of America 10:45 - Mid-Morning Coffee Break and Networking in the Exhibit Hall 11:15 - Characterization of Proteins and Extracellular RNAs in Vesicles and Viruses for Cancer and COVID-19 Detection Eduardo Reategui, Distinguished Assistant Professor of Engineering, The Ohio State University, United States of America 11:45 - Effect of Plasma Exosome Isolation Methods on Multi-Omic Profiles in Cancer Patients and Healthy Controls Liang Wang, Senior Member of Tumor Biology, Moffitt Cancer Center, United States of America 12:15 - Networking Lunch - Network with Colleagues and Meet Exhibitors Session Title: Technologies Driving EV Research Forward 13:00 - Terry Morgan - Keynote Presentation NanoFACs EV Sorting - Strengths and Limitations Terry Morgan, Professor, Oregon Health and Science University, United States of America 13:30 - NanoFCM Technology Spotlight Presentation 14:00 - Particle Metrix GmbH Technolology Spotlight Presentation 14:30 - Next-Generation Nanoplasmonic Sensing Technologies for Multiplexed Single Extracellular Vesicle Analysis Hyungsoon Im, Assistant Professor, Center for Systems Biology, Mass General Hospital (MGH)/Harvard Medical School, United States of America 15:00 - Mid-Afternoon Coffee Break and Networking in the Exhibit Hall 15:30 - Andrew Godwin - Keynote Presentation Title to be Confirmed. Andrew Godwin, Professor and Division Director, Genomic Diagnostics, Founding Director, Kansas Institute for Precision Medicine, Deputy Director, KU Cancer Center, University of Kansas Medical Center, United States of America 16:00 - Fatah Kashanchi - Keynote Presentation Cross Talk Between Viruses and EV Biogenesis Fatah Kashanchi, Professor and Director of Research, Lab of Molecular Virology, George Mason University, United States of America 16:30 - Cytek BioSciences Technology Spotlight Presentation 17:00 - The AlphaV-Beta3 Integrin/NgR2 Complex is Up-regulated in Prostate Cancer Cell-derived EVs and Patient-derived EVs and Represents a Promising Therapeutic Target Anna Testa, Medical Resident, Thomas Jefferson University; Internal Medicine Fellow, University of Tur, United States of America 17:15 - Extracellular Vesicles-Enabled Liquid Biopsy for Cancer Diagnosis, Prognosis, and Treatment Yong Zeng, Associate Professor, Department of Chemistry, University of Florida, United States of America 17:45 - Close of Day 1 Conference Programming + Networking Reception with Beer and Wine 18:45 - Close of Conference Day Thursday, 27 July 2023 08:00 - Morning Coffee and Networking in the Exhibit Hall 08:30 - Mei He - Conference Chair EVs for Therapeutics - Welcome and Introduction by Conference Co-Chairperson Mei He, Assistant Professor, University of Florida, United States of America 08:45 - Michael Graner - Conference Chair EVs for Therapeutics - Welcome and Introduction by Conference Co-Chairperson Michael Graner, Professor, Dept of Neurosurgery, University of Colorado Anschutz School of Medicine, United States of America 09:00 - Steve Soper - Keynote Presentation Title to be Confirmed. Steve Soper, Foundation Distinguished Professor, Director, Center of BioModular Multi-scale System for Precision Medicine, The University of Kansas, United States of America 09:30 - James Lee - Keynote Presentation Exosome mRNA-Based Gene Therapy for Regenerative Medicine and Cancer Treatment James Lee, Helen C. Kurtz Professor of Chemical and Biomolecular Engineering, The Ohio State University, United States of America 10:00 - Damien Pearse - Keynote Presentation Glial Cell-Derived EVs for Axon Growth and Neurorepair Damien Pearse, Professor, Department of Neurological Surgery; The John M. and Jocelyn H.K. Watkins Distinguished Chair in Cell Therapies, University of Miami Miller School of Medicine, United States of America 10:30 - Mid-Morning Coffee Break and Networking in the Exhibit Hall 11:00 - Aethlon MedicalThe Aethlon Hemopurifier for the Removal of Enveloped Viruses and Injurious Extracellular Vesicles Steven LaRosa, Chief Medical Officer, Aethlon Medical 11:30 - Enhancing Therapeutic Extracellular Vesicle Biomanufacturing via Mechanoregulation Steven Jay, Associate Professor, University of Maryland, United States of America 12:00 - X-Cell Therapeutics Technology Spotlight Presentation 12:30 - Aijun Wang - Keynote Presentation Engineered Stem Cell-Derived Extracellular Vesicles: Promising Theranostics for Tissue Regeneration Aijun Wang, Chancellor's Fellow Professor, University of California-Davis, United States of America 13:00 - Networking Lunch - Network with Colleagues and Meet Exhibitors 13:30 - Large Scale Manufacturing and Functional Assessment of Extracellular Vesicles Heather Branscome, Supervisor, Laboratory Operations, ATCC and Research Assistant, George Mason University, United States of America 14:00 - EVs and the Inner Ear: Diagnostic and Treatment Opportunities Hinrich Staecker, David and Mary Zamierowsky Professor, Department of Otolaryngology, University of Kansas Health System, United States of America 14:30 - An Effective Peptide-based Platform for Efficient Exosomal Loading and Cellular Delivery of a microRNA Zucai Suo, Eminent Professor & Dorian and John Blackmon Chair in Biomedical Science, Florida State University College of Medicine, United States of America 15:00 - Stimulating Production of Osteoclast-derived Regulatory Extracellular Vesicles to Therapeutically-control Bone Remodeling Shannon Holliday, Associate Professor of Orthodontics and Anatomy & Cell Biology, University of Florida, United States of America 15:30 - Delivery of Mitochondria-Containing Extracellular Vesicles to the BBB Devika Manickam, Associate Professor, Duquesne University, United States of America 16:00 - Shilpa Buch - Keynote Presentation Astrocytes at the Crossroads of HIV and Alzheimer's Disease Shilpa Buch, Professor and Senior Executive Vice Chair for Research, University of Nebraska Medical Center, United States of America 16:30 - sEV Sub-populations Derived from Cancer Cells that Express the AlphaVBeta3 Integrin Cecilia Verrillo, Research Student, Thomas Jefferson University, United States of America 16:45 - Extracellular Vesicle-Mediated Amyloid Transfer and Intercellular Communication within the Neurovascular Unit Michal Toborek, Professor and Vice-Chair for Research, University of Miami School of Medicine, United States of America 17:15 - Extracellular Vesicles-mediated Organ Crosstalk in Systemic Inflammatory Disorders Nazli Khodayari, Assistant Professor, Department of Medicine, University of Florida, United States of America 17:45 - Genetic Engineering of Nanoscale Exosomes for Targeted Drug Delivery and Therapy Bill Lu, Associate Professor, Santa Clara University, United States of America 18:15 - Title to be Confirmed. Daniel Gallego-Perez, Associate Professor, The Ohio State University, United States of America 18:30 - Title to be Confirmed. Natalia Higuita-Castro, Assistant Professor, The Ohio State University, United States of America 18:45 - Close of Day 2 Conference Programming For more information about this conference visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

DUBLIN, June 19, 2023 /PRNewswire/ -- The "Extracellular Vesicles 2023: Technologies, Biomarker Cargo & Diagnostics" conference has been added to ResearchAndMarkets.com's offering. Welcome to the Extracellular Vesicles 2023 Conference: From Technologies to Biomarker Cargo to Diagnostics. This conference is being held July 26-27, 2023 in Orlando, Florida close to the Walt Disney World Resort and Attractions. The host is honored to welcome Professor Mei He, University of Florida as Conference Chairperson. This conference brings together academic and industry participants for a 2-day deep dive into timely topics in the Extracellular Vesicles (EVs) field with emphasis on technologies for the isolation and study of extracellular vesicles as well as the downstream studies in the EV field such as therapeutics development. In addition to the biomarker and diagnostic potential of EVs, we explore at this conference the latest work and developments in EV-based Therapeutics and the Drug Delivery and Therapeutics Opportunities in the EV Field. Presentations at this conference from academics as well as industry participants and the goal is 2 days of scientific exchange as well as networking opportunities. We welcome exhibitors and companies in the field to engage and participate at this conference and showcase their latest developments and offerings to the field. **This is a 2-Track Conference with Attendees Accessing All 2-Tracks** One Track Focuses on EV Technologies, Biomarkers & Diagnostics The Other Track Focuses on EV-based Drug Delivery, Biologics, and Therapeutics Development Agenda Topics Biomarker Content of Extracellular Vesicles and Role for Diagnostics Development Proteins and Lipids Small RNAs such as microRNA Cargo within EVs Technologies for the Study of EV RNA Cargo such as RNA-Seq Disease Areas Where EV-based Diagnostics Being Developed Single Extracellular Vesicle (EV) Analysis by Flow Cytometry Technologies for the Isolation, Characterization, and Study of Extracellular Vesicles (EVs)-Exosomes Agenda: Wednesday, 26 July 2023 08:00 - Conference Registration and Materials Pick-Up + Coffee Session Title: Where Does the Field of EVs Stand, circa 2023? 09:00 - Mei He - Conference Chair Welcome and Introduction by Conference Co-Chairperson Mei He, Assistant Professor, University of Florida, United States of America 09:05 - Michael Graner - Conference Chair Welcome and Introduction by Conference Co-Chairperson Michael Graner, Professor, Dept of Neurosurgery, University of Colorado Anschutz School of Medicine, United States of America 09:15 - Lucia Languino - Keynote Presentation Extracellular Vesicle Integrins: Novel Opportunities for the Diagnosis and Therapy of Cancer Lucia Languino, Professor of Cancer Biology, Thomas Jefferson University, United States of America 09:45 - Dominique PV de Kleijn - Keynote Presentation Plasma Extracellular Vesicles for Cardiovascular Disease Dominique PV de Kleijn, Professor Experimental Vascular Surgery, Professor Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands, Netherlands 10:15 - Kristin Kopperud - Keynote Presentation Low Earth Orbit Research Opportunities on the International Space Station Kristin Kopperud, Program Director, Biomedicine, International Space Station National Laboratory, United States of America 10:45 - Mid-Morning Coffee Break and Networking in the Exhibit Hall 11:15 - Characterization of Proteins and Extracellular RNAs in Vesicles and Viruses for Cancer and COVID-19 Detection Eduardo Reategui, Distinguished Assistant Professor of Engineering, The Ohio State University, United States of America 11:45 - Effect of Plasma Exosome Isolation Methods on Multi-Omic Profiles in Cancer Patients and Healthy Controls Liang Wang, Senior Member of Tumor Biology, Moffitt Cancer Center, United States of America 12:15 - Networking Lunch - Network with Colleagues and Meet Exhibitors Session Title: Technologies Driving EV Research Forward 13:00 - Terry Morgan - Keynote Presentation NanoFACs EV Sorting - Strengths and Limitations Terry Morgan, Professor, Oregon Health and Science University, United States of America 13:30 - NanoFCM Technology Spotlight Presentation 14:00 - Particle Metrix GmbH Technolology Spotlight Presentation 14:30 - Next-Generation Nanoplasmonic Sensing Technologies for Multiplexed Single Extracellular Vesicle Analysis Hyungsoon Im, Assistant Professor, Center for Systems Biology, Mass General Hospital (MGH)/Harvard Medical School, United States of America 15:00 - Mid-Afternoon Coffee Break and Networking in the Exhibit Hall 15:30 - Andrew Godwin - Keynote Presentation Andrew Godwin, Professor and Division Director, Genomic Diagnostics, Founding Director, Kansas Institute for Precision Medicine, Deputy Director, KU Cancer Center, University of Kansas Medical Center, United States of America 16:00 - Fatah Kashanchi - Keynote Presentation Cross Talk Between Viruses and EV Biogenesis Fatah Kashanchi, Professor and Director of Research, Lab of Molecular Virology, George Mason University, United States of America 16:30 - Cytek BioSciences Technology Spotlight Presentation 17:00 - The AlphaV-Beta3 Integrin/NgR2 Complex is Up-regulated in Prostate Cancer Cell-derived EVs and Patient-derived EVs and Represents a Promising Therapeutic Target Anna Testa, Medical Resident, Thomas Jefferson University; Internal Medicine Fellow, University of Tur, United States of America 17:15 - Extracellular Vesicles-Enabled Liquid Biopsy for Cancer Diagnosis, Prognosis, and Treatment Yong Zeng, Associate Professor, Department of Chemistry, University of Florida, United States of America 17:45 - Close of Day 1 Conference Programming + Networking Reception with Beer and Wine 18:45 - Close of Conference Day Thursday, 27 July 2023 08:00 - Morning Coffee and Networking in the Exhibit Hall 08:30 - Mei He - Conference Chair EVs for Therapeutics - Welcome and Introduction by Conference Co-Chairperson Mei He, Assistant Professor, University of Florida, United States of America 08:45 - Michael Graner - Conference Chair EVs for Therapeutics - Welcome and Introduction by Conference Co-Chairperson Michael Graner, Professor, Dept of Neurosurgery, University of Colorado Anschutz School of Medicine, United States of America 09:00 - Steve Soper - Keynote Presentation Steve Soper, Foundation Distinguished Professor, Director, Center of BioModular Multi-scale System for Precision Medicine, The University of Kansas, United States of America 09:30 - James Lee - Keynote Presentation Exosome mRNA-Based Gene Therapy for Regenerative Medicine and Cancer Treatment James Lee, Helen C. Kurtz Professor of Chemical and Biomolecular Engineering, The Ohio State University, United States of America 10:00 - Damien Pearse - Keynote Presentation Glial Cell-Derived EVs for Axon Growth and Neurorepair Damien Pearse, Professor, Department of Neurological Surgery; The John M. and Jocelyn H.K. Watkins Distinguished Chair in Cell Therapies, University of Miami Miller School of Medicine, United States of America 10:30 - Mid-Morning Coffee Break and Networking in the Exhibit Hall 11:00 - Aethlon MedicalThe Aethlon Hemopurifier for the Removal of Enveloped Viruses and Injurious Extracellular Vesicles Steven LaRosa, Chief Medical Officer, Aethlon Medical 11:30 - Enhancing Therapeutic Extracellular Vesicle Biomanufacturing via Mechanoregulation Steven Jay, Associate Professor, University of Maryland, United States of America 12:00 - X-Cell Therapeutics Technology Spotlight Presentation 12:30 - Aijun Wang - Keynote Presentation Engineered Stem Cell-Derived Extracellular Vesicles: Promising Theranostics for Tissue Regeneration Aijun Wang, Chancellor's Fellow Professor, University of California-Davis, United States of America 13:00 - Networking Lunch - Network with Colleagues and Meet Exhibitors 13:30 - Large Scale Manufacturing and Functional Assessment of Extracellular Vesicles Heather Branscome, Supervisor, Laboratory Operations, ATCC and Research Assistant, George Mason University, United States of America 14:00 - EVs and the Inner Ear: Diagnostic and Treatment Opportunities Hinrich Staecker, David and Mary Zamierowsky Professor, Department of Otolaryngology, University of Kansas Health System, United States of America 14:30 - An Effective Peptide-based Platform for Efficient Exosomal Loading and Cellular Delivery of a microRNA Zucai Suo, Eminent Professor & Dorian and John Blackmon Chair in Biomedical Science, Florida State University College of Medicine, United States of America 15:00 - Stimulating Production of Osteoclast-derived Regulatory Extracellular Vesicles to Therapeutically-control Bone Remodeling Shannon Holliday, Associate Professor of Orthodontics and Anatomy & Cell Biology, University of Florida, United States of America 15:30 - Delivery of Mitochondria-Containing Extracellular Vesicles to the BBB Devika Manickam, Associate Professor, Duquesne University, United States of America 16:00 - Shilpa Buch - Keynote Presentation Astrocytes at the Crossroads of HIV and Alzheimer's Disease Shilpa Buch, Professor and Senior Executive Vice Chair for Research, University of Nebraska Medical Center, United States of America 16:30 - sEV Sub-populations Derived from Cancer Cells that Express the AlphaVBeta3 Integrin Cecilia Verrillo, Research Student, Thomas Jefferson University, United States of America 16:45 - Extracellular Vesicle-Mediated Amyloid Transfer and Intercellular Communication within the Neurovascular Unit Michal Toborek, Professor and Vice-Chair for Research, University of Miami School of Medicine, United States of America 17:15 - Extracellular Vesicles-mediated Organ Crosstalk in Systemic Inflammatory Disorders Nazli Khodayari, Assistant Professor, Department of Medicine, University of Florida, United States of America 17:45 - Genetic Engineering of Nanoscale Exosomes for Targeted Drug Delivery and Therapy Bill Lu, Associate Professor, Santa Clara University, United States of America 18:15 - Title to be Confirmed. Daniel Gallego-Perez, Associate Professor, The Ohio State University, United States of America 18:30 - Title to be Confirmed. Natalia Higuita-Castro, Assistant Professor, The Ohio State University, United States of America 18:45 - Close of Day 2 Conference Programming For more information about this conference visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

Researchers discover a potential therapeutic avenue via neuronal endocrine receptors that could be helpful in battling an aggressive form of prostate cancer. Prostate cancer is the second most common cancer and the second leading cause of cancer death among American men. Now, researchers have discovered key molecular players that drive prostate cancer to progress into a highly aggressive form of the disease called neuroendocrine prostate cancer that currently has no effective treatment. The finding uncovers new avenues to explore for therapeutics to treat neuroendocrine prostate cancer. "We have found novel pathways that promote neuroendocrine prostate cancer," says senior author Lucia R. Languino, PhD, a professor in the department of Pharmacology, Physiology and Cancer Biology and director of the Genetics, Genomics, and Cancer Biology PhD Program at Thomas Jefferson University. She and her team published the new research online on November 7, 2022 in the journal Scientific Reports. Most prostate cancers are a type of disease called prostate adenocarcinoma. Other types of prostate cancer, including neuroendocrine tumors, are rare. However, unlike prostate adenocarcinoma, neuroendocrine prostate cancer is very aggressive and can quickly spread to other parts of the body. Treatments that are effective for adenocarcinomas in the prostate do not work against neuroendocrine prostate cancers. Adenocarcinoma prostate cancers can progress into neuroendocrine prostate cancer. Until now, how this transition occurs has been a mystery. To better understand how neuroendocrine prostate cancer develops, Dr. Languino and colleagues looked for biomarkers of the disease. In previous work, they discovered that a molecule known as aVb3 integrin is abundant in mice and humans with neuroendocrine prostate cancer, but missing in prostate adenocarcinoma. To look for molecules unique to neuroendocrine prostate cancer, the researchers found that aVb3 integrin expression in prostate cancer cells bumped up the expression of a known marker of neuroendocrine prostate cancer and significantly increased the expression of a molecule called Nogo receptor 2 (NgR2). The finding "was a big discovery," Dr. Languino says, who is also a researcher with the Sidney Kimmel Cancer Center -- Jefferson Health. That's because NgR2 is a protein found in nerve cells, where it contributes to neuronal functions. It has never before been studied in cancer, of any kind. Dr. Languino and her colleagues wanted to find out what this molecule, a neuronal protein, is doing in cancer. An initial experiment revealed that NgR2 binds the aVb3 integrin. The scientists also saw that in mice with neuroendocrine prostate tumors, aVb3 integrin and NgR2 were both present in the primary tumor and in cancerous lesions that had formed in the lungs of the animals. A follow-up experiment made it clear that both aVb3 integrin and NgR2 are necessary for neuroendocrine prostate cancers. When Dr. Languino and her team lowered the amount of NgR2 in neuroendocrine prostate cancer cells, neuroendocrine markers also decreased. The results suggest that NgR2 plays a role in the development of neuroendocrine prostate cancer. Lowering the amount of NgR2 also reduced the ability of cancer cells to grow and move, indicating that NgR2 may have a hand in cancer spreading to other parts of the body, in a process known as metastasis. Metastases are often what makes cancers fatal. "These two molecules, aVb3 integrin and NgR2, seem to create a combination that is lethal," Dr. Languino says. She and her colleagues are now looking for a molecule or antibody that would block the effect of NgR2, or the aVb3 integrin/NgR2 complex, to inhibit their ability to promote neuroendocrine prostate cancer growth and development, and make the cancer more susceptible to therapy. All funding sources and support as well as competing interests and ethics declarations are listed at the end of the article cited below.